Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ADP | 4.5fold activation of NADH:ubiquinone oxidoreductase at 0.1 M | Bos taurus | |
ATP | 10fold activation of NADH:ubiquinone oxidoreductase at 0.1 M, ATP in the micromolar concentration range specifically stimulates the NADH:hexaammineruthenium(III) (HAR) reductase activity catalyzed by eukaryotic complex I when assayed at low NADH and acceptor concentrations | Bos taurus | |
ATP | ATP in the micromolar concentration range specifically stimulates the NADH:hexaammineruthenium(III) (HAR) reductase activity catalyzed by eukaryotic complex I when assayed at low NADH and acceptor concentrations | Yarrowia lipolytica | |
additional information | no activation by adenylylimidodiphosphate, GTP, GDP, adenosine, AMP, cAMP, and CTP | Bos taurus | |
additional information | no stimulation of the three-subunit FP fragment of complex I or for membrane-bound NDH-1 by ATP | Paracoccus denitrificans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | submitochondrial fragments | Bos taurus | 5739 | - |
mitochondrion | submitochondrial fragments | Yarrowia lipolytica | 5739 | - |
plasma membrane | - |
Paracoccus denitrificans | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Paracoccus denitrificans | - |
- |
- |
Yarrowia lipolytica | - |
var. alkalitolerance | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme shows also rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase activity | Bos taurus | ? | - |
? | |
additional information | the enzyme shows also rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase activity | Yarrowia lipolytica | ? | - |
? | |
additional information | the enzyme shows also rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase activity. The enzyme NDH-1 catalyzes a number of the NADH:artificial electron acceptor oxidoreductase activities showing particularly high turnover numbers with ferricyanide and hexaammineruthenium(III), kinetic patterns of the steady-state NADH oxidation with these two electron acceptors, overview | Paracoccus denitrificans | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mitochondrial NADH:ubiquinone oxidoreductase | - |
Bos taurus |
mitochondrial NADH:ubiquinone oxidoreductase | - |
Yarrowia lipolytica |
NADH:HAR reductase | - |
Paracoccus denitrificans |
NADH:HAR reductase | - |
Bos taurus |
NADH:HAR reductase | - |
Yarrowia lipolytica |
NDH-1 | prokaryotic complex I homolog | Paracoccus denitrificans |
respiratory complex I | - |
Bos taurus |
respiratory complex I | - |
Yarrowia lipolytica |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Paracoccus denitrificans |
30 | - |
assay at | Bos taurus |
30 | - |
assay at | Yarrowia lipolytica |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Paracoccus denitrificans |
8 | - |
assay at | Bos taurus |
8 | - |
assay at | Yarrowia lipolytica |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Paracoccus denitrificans | |
NADH | - |
Bos taurus | |
NADH | - |
Yarrowia lipolytica |
General Information | Comment | Organism |
---|---|---|
additional information | the accessory subunits of eukaryotic complex I bear an allosteric ATP binding site | Paracoccus denitrificans |
additional information | the accessory subunits of eukaryotic complex I bear an allosteric ATP binding site | Yarrowia lipolytica |
additional information | the accessory subunits of eukaryotic complex I bear an allosteric ATP binding site | Bos taurus |