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EC Number	Activating Compound	Commentary	Reference
1.13.11.52	1-(1H-indol-3-yl)ethanol	effector	698485
1.13.11.52	3-indoleethanol	1 mM, enhances activity by 87%	663996
1.13.11.52	4-Hydroxypyrazole	below 0.1 mM, activation	395479
1.13.11.52	alpha-interferon	induces de novo synthesis of IDO, but 2 to 3 orders of magnitude less than gamma-IFN	666763
1.13.11.52	alpha-interferon	induces IDO expression in monocytes	666895
1.13.11.52	alpha-methyl-DL-tryptophan	can activate the enzyme when lower concentrations of L-Trp are used	395490
1.13.11.52	ascorbate	promotes IDO peroxidase turnover by reducing Compound II	725522
1.13.11.52	ascorbic acid	-	711229
1.13.11.52	ascorbic acid	9.2 mM required for half-maximal activity	395491
1.13.11.52	ascorbic acid	activates	395494

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Release 2023.1 (January 2023)