EC Number   |
Inhibitors |
Structure  |
|---|
   7.1.1.1 | NADPH |
- |
   |
| 7.1.1.1 | NADH |
high concentrations of NADH lead to substrate inhibition |
|
| 7.1.1.1 | NADP+ |
mixed product inhibition vs. acetylpyridine adenine dinucleotide, competitive vs. NADPH |
|
| 7.1.1.1 | Zn2+ |
low concentrations of Zn2+ strongly inhibit revers transhydrogenation |
|
| 7.1.1.1 | N-ethylmaleimide |
cysteine-free mutant enzyme is not inhibited |
|
| 7.1.1.1 | N-ethylmaleimide |
0.2 mM, 57% inhibition of reverse reaction in A348C mutant enzyme, 60% inhibition of K424C mutant enzyme, more than 95% inhibition of A390C mutant enzyme after 1h, R425C mutant enzyme is not inhibited |
|
| 7.1.1.1 | N-ethylmaleimide |
- |
|
| 7.1.1.1 | NAD(P)+ |
- |
|
| 7.1.1.1 | Cd2+ |
low concentrations of Cd2+ strongly inhibit revers transhydrogenation |
|
| 7.1.1.1 | 5'-AMP |
- |
|
