EC Number   |
Application |
Reference  |
|---|
    1.13.11.27 | medicine |
mechanism of binding of the inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione used to treat type I tyrosinemia. Enzyme-Fe(II)-inhibitor complex does not oxidize, dissociation rate constant is essentially zero |
657941 |
| 1.13.11.27 | agriculture |
overexpression of enzyme in Nicotiana tabacum, transgenic plants have a 10-fold higher resistance to the bleaching herbicide sulcotrione, transgenic seeds have an up to two-fold enhanced level of vitamin E without change in the ratio of gamma-tocopherol and gamma-tocotrienol. Level of plastoquinone is enhanced in leaves of transgenic lines during leaf senescence |
658710 |
| 1.13.11.27 | agriculture |
plant 4-hydroxyphenylpyruvate dioxygenase (HPPD) is the molecular target of a range of commercial synthetic beta-triketone herbicides Their mode of action is based on an irreversible inhibition of HPPD |
741741 |
| 1.13.11.27 | drug development |
plant 4-hydroxyphenylpyruvate dioxygenase (HPPD) is the molecular target for development of specific inhibitors |
741741 |
| 1.13.11.27 | agriculture |
the enzyme is a target for herbicides, e.g. triketone inhibitors |
741762 |
| 1.13.11.27 | drug development |
the enzyme is a target for inhibitor and herbicide development |
741762 |
| 1.13.11.27 | drug development |
the human enzyme is a target for drug development in treatment of type 1 tyrosinemia, alkaptonuria, and hawkinsinuria, overvuew |
741762 |
| 1.13.11.27 | drug development |
the enzyme is an important target for treating type I tyrosinemia and alkaptonuria due to its significant role in tyrosine catabolism |
742068 |
| 1.13.11.27 | medicine |
compounds N-(4-methoxyphenyl)-7-nitro-2,1,3-benzoxadiazol-4-amine and 3-(2-bromo-4-methylphenyl)-6-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-methylquinazolin-4(3H)-one can be potentially useful for the treatment of type I tyrosinemia and other diseases with defects in tyrosine degradation |
742068 |
| 1.13.11.27 | drug development |
4-hydroxyphenylpyruvate dioxygenase (HPPD), an essential enzyme in tyrosine catabolism, is an important target for treating type I tyrosinemia |
742451 |
