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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.2.7.10physiological function CoA has no effect on catalysis by OOR. OOR binds pyruvate and catalyzes decarboxylation to form the same hydroxyethylidine-thiamine diphosphate intermediate and one-electron transfer to generate the hydroxyethylidine-thiamine diphosphate radical as does pyruvate:ferredoxin oxidoreductase, EC 1.2.7.1. In OOR, this intermediate remains stranded at the active site as a covalent inhibitor. OOR generates an oxalate-derived adduct with thiamine diphosphate (oxalyl-TPP) that undergoes decarboxylation and one-electron transfer to form a radical intermediate remaining bound to thiamine diphosphate 762726
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