EC Number |
General Information |
Reference |
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2.3.1.194 | malfunction |
knockdown of AACS in primary neurons caused decreases in the expression of MAP-2 and NeuN, which are markers of neuronal differentiation, as well as synaptopodin, a marker of spine apparatus |
718764 |
2.3.1.194 | metabolism |
polyhydroxyalkanoate synthase, PhaC, catalyzes generation of (R)-3-hydroxybutyrate monomers from two acetyl-CoA molecules, and further of short-chain length polyhydroxyalkanoates, PHAs. The malonyl-CoA availability is a limiting factor to synthesis of poly(3-hydroxybutyrate), P(3HB), thus acetoacetyl-CoA synthetase, which is controlling the malonyl-CoA pool, is an important enzyme for increasing the P(3HB) production |
714539 |
2.3.1.194 | metabolism |
the acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily is involved in the mevalonate pathway. Acetoacetyl-CoA is the precursor of 3-hydroxy-3-methylglutaryl-CoA in the mevalonate pathway, which is essential for terpenoid backbone biosynthesis. Acetoacetyl-CoA is also the precursor of poly-3-hydroxybutyrate, a polymer belonging to the polyester class produced by microorganisms |
706551 |
2.3.1.194 | more |
alterations in acety-CoA carboxylase activity to optimize the acetyl-CoA/malonyl-CoA ratio might be an effective way to increase poly(3-hydroxybutyrate) production via the AACS-catalyzed paythway |
714539 |
2.3.1.194 | more |
SREBP-2, a key transcription factor of cholesterol synthesis, interacts with the AACS promoter and is increased during neurite outgrowth, and knockdown of SREBP-2 down-regulates the mRNA levels of AACS in Neuro-2a cells |
718764 |
2.3.1.194 | physiological function |
acetoacetyl-CoA synthetase is a ketone body-utilizing enzyme for the synthesis of cholesterol and fatty acids, regulation of AACS during neurite outgrowth and physiological role of AACS in neurogenesis, overview. AACS is regulated by SREBP-2 and involved in the normal development of neurons |
718764 |