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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.3582-dehydropantolactone + NADPH + H+ recombinant CorCPR exhibited a high catalytic activity for the synthesis of (R)-pantolactone ((R)-PL) from 2-dehydropantolactone (KPL). The activity assay is performed using purified CorCPR and crude recombinant GDH in a single batch reaction. GDH is used to complete the enzyme-coupled NADPH regeneration system. CPR-01 form Candida orthopsilosis Co 90-125 exhibits excellent enantioselectivity (enantiomeric excess of over 99%). CorCPR exhibits the highest activity and stereoselectivity toward KPL Candida orthopsilosis Co 90-125 (R)-pantolactone + NADP+ - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.3582-dehydropantolactone + NADPH + H+ - Candida parapsilosis IFO 0708 (R)-pantolactone + NADP+ - ir
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.3582-dehydropantolactone + NADPH + H+ - Candida parapsilosis IFO 0708 (R)-pantolactone + NADP+ - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.3582-dehydropantolactone + NADPH + H+ - Candida dubliniensis NCPF 3949 (R)-pantolactone + NADP+ - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.3582-dehydropantolactone + NADPH + H+ - Candida dubliniensis NRRL Y-17841 (R)-pantolactone + NADP+ - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.3582-dehydropantolactone + NADPH + H+ - Candida dubliniensis CBS 7987 (R)-pantolactone + NADP+ - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.3585-methylisatin + NADPH + H+ 108% of the activity compared to isatin Candida parapsilosis ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.358camphorquinone + NADPH + H+ 97% of the activity compared to isatin Candida parapsilosis ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.358isatin + NADPH + H+ - Candida parapsilosis ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.358more enzyme CduCPR shows high catalytic activity and stereoselectivity using 2-dehydropantolactone (KPL) as the substrate. In a continuous feeding reaction, 200 mM ketopantolactone is reduced to (R)-pantolactone with 98% conversion and 99% enantiomeric excess within 2.0 h by the purified recombinant enzyme Candida dubliniensis ? - -
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