EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.11.29 | hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 |
hypoxia-inducible factor 1alpha is hydroxylated at Pro402 and Pro564 |
Caenorhabditis elegans |
hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 |
- |
? |
1.14.11.29 | hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 |
hypoxia-inducible factor 1alpha is hydroxylated at Pro402 and Pro564 |
Drosophila melanogaster |
hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 |
- |
? |
1.14.11.29 | DALDLEMLAPYISMDDDFQL + 2-oxoglutarate + O2 |
a HIF-3alpha peptide. Vmax is 120% of the activity with DLDLEMLAPYIPMDDDFQL |
Homo sapiens |
? |
- |
? |
1.14.11.29 | DALDLEMLAPYISMDDDFQL + 2-oxoglutarate + O2 |
a HIF-3alpha peptide. Vmax is 120% of the activity with DLDLEMLAPYIPMDDDFQL |
Homo sapiens |
DALDLEMLA-((4R)-4-hydroxy-L-proline)-YISMDDDFQL + succinate + CO2 |
- |
? |
1.14.11.29 | DALDLEMLAPYISMDDDFQL + 2-oxoglutarate + O2 |
a HIF-3alpha peptide. Vmax is 150% of the activity with DLDLEMLAPYIPMDDDFQL |
Homo sapiens |
DALDLEMLA-((4R)-4-hydroxy-L-proline)-YISMDDDFQL + succinate + CO2 |
- |
? |
1.14.11.29 | DALTLLAPAAGDTIISLDF + 2-oxoglutarate + O2 |
hybrid substrate derived from C-terminal and N-terminal oxygen-dependent degradation domain |
Homo sapiens |
DALTLLA-((4R)-4-hydroxy-L-proline)-AAGDTIISLDF + succinate + CO2 |
- |
? |
1.14.11.29 | DALTLLAPAAGDTIISLDF + 2-oxoglutarate + O2 |
substrate derived from N-terminal oxygen-dependent degradation domain |
Homo sapiens |
DLDLEMLA-((4R)-4-hydroxy-L-proline)-AAGDTIISLDF + succinate + CO2 |
- |
? |
1.14.11.29 | DALTLLAPAAGDTIISLFG + 2-oxoglutarate + O2 |
N-terminal hydroxylation site of HIF-1alpha, Vmax is 100% of the activity with DLDLEMLAPYIPMDDDFQL |
Homo sapiens |
DALTLLA-((4R)-4-hydroxy-L-proline)-AAGDTIISLFG + succinate + CO2 |
- |
? |
1.14.11.29 | DALTLLAPAAGDTIISLFG + 2-oxoglutarate + O2 |
N-terminal hydroxylation site of HIF-1alpha, Vmax is 60% of the activity with DLDLEMLAPYIPMDDDFQL |
Homo sapiens |
DALTLLA-((4R)-4-hydroxy-L-proline)-AAGDTIISLFG + succinate + CO2 |
- |
? |
1.14.11.29 | DLDLEALAPYIPADDDFQL + 2-oxoglutarate + O2 |
- |
Homo sapiens |
DLDLEALA-((4R)-4-hydroxy-L-proline)-YIPADDDFQL + succinate + CO2 |
- |
? |