EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level  |
|---|
    2.5.1.29 | Acute Lung Injury |
30652497 |
Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression. |
ongoing research
therapeutic application
unassigned |
3
2
0 |
| 2.5.1.29 | Acute Lung Injury |
33729030 |
Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 2.5.1.29 | Ataxia |
31570763 |
Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition. |
ongoing research
therapeutic application
unassigned |
4
3
0 |
| 2.5.1.29 | Azoospermia |
31171774 |
The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood-testis barrier and results in hypospermatogenesis. |
causal interaction
diagnostic usage
unassigned |
3
1
0 |
| 2.5.1.29 | Bone Resorption |
21419634 |
Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
1
1
4
0 |
| 2.5.1.29 | Breast Neoplasms |
21335425 |
Bisphosphonates Induce Autophagy by Depleting Geranylgeranyl Diphosphate. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
1
1
1
0 |
| 2.5.1.29 | Cholestasis |
31905247 |
Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism. |
causal interaction
ongoing research
unassigned |
1
1
0 |
| 2.5.1.29 | Dystocia |
33340314 |
Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction. |
causal interaction
unassigned |
4
0 |
| 2.5.1.29 | Fatty Liver |
29971772 |
Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
2
3
1
0 |
| 2.5.1.29 | geranylgeranyl diphosphate synthase deficiency |
31120854 |
Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-?1/BMP-4 signaling. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
2
4
0 |
