1.1.1.87: homoisocitrate dehydrogenase
This is an abbreviated version!
For detailed information about homoisocitrate dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.87
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1.1.1.87
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alpha-aminoadipate
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3-isopropylmalate
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homocitrate
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homoaconitase
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beta-decarboxylating
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alpha-ketoadipate
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medicine
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synthesis
- 1.1.1.87
- alpha-aminoadipate
- 3-isopropylmalate
- homocitrate
- homoaconitase
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beta-decarboxylating
- alpha-ketoadipate
- medicine
- synthesis
Reaction
Synonyms
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), beta-decarboxylating dehydrogenase, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, LYS12, protein PH1722, ScHICDH, TK0280
ECTree
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Crystallization
Crystallization on EC 1.1.1.87 - homoisocitrate dehydrogenase
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His6-tagged recombinant apoenzyme, hanging drop vapor diffusion method, using 100 mM HEPES-NaOH (pH 7.5), 200 mM NaCl, and 10% (v/v) 2-propanol. Enzyme in complex with homoisocitrate and Mn2+, hanging drop vapor diffusion method, using 100 mM HEPES-NaOH (pH 7.5), 200 mM NaCl, and 10% (v/v) 2-propanol. Enzyme in complex with isocitrate and Mn2+, hanging drop vapor diffusion method, using 100 mM Tris-HCl (pH 7.5), 200 mM NaCl, and 30% (v/v) 2-methyl-2,4-pentanediol. Enzyme in complex with 3-isopropylmalate and Mn2+, hanging drop vapor diffusion method, using 100 mM HEPES-NaOH (pH 7.5), 200 mM NaCl, and 36% (v/v) 2-methyl-2,4-pentanediol
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enzyme in binary complex with inhibitor (2S,3S)-thiahomoisocitrate, sitting drop vapour diffusion method, 0.00 ml of 8.7 mg/ml protein in 5 mM Tris-HCl, pH 7.8. 0.8 mM inhibitor, and 1.7 mM NAD, is mixed with 0.002 ml of reservoir solution containing 40% 2-methyl-2,4-pentandiol and 100 mM citrate pH 4.85, eqilibration against 1 ml resetvoir solution, X-ray diffrcation structure determination and analysis at 2.6 A resolution, molecular replacement
purified recombinant enzyme, hanging drop vapour diffusion method, 10 mg/ml protein with reservoir solution containing 24% PEG 400, and 0.1 M citrate, pH 4.8, addition of 0.003 ml drops of 0.1 M MgCl2, 5 mM isocitrate or homoisocitrate, and of a 0.001 ml drop 50 mM CdCl2, equilibration against 0.5 ml reservoir solution, 5 days at 20°C, X-ray diffraction structure determination and analysis at 1.85 A resolution, molecular replacement
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