1.1.1.87: homoisocitrate dehydrogenase
This is an abbreviated version!
For detailed information about homoisocitrate dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.87
-
1.1.1.87
-
alpha-aminoadipate
-
3-isopropylmalate
-
homocitrate
-
homoaconitase
-
beta-decarboxylating
-
alpha-ketoadipate
-
medicine
-
synthesis
- 1.1.1.87
- alpha-aminoadipate
- 3-isopropylmalate
- homocitrate
- homoaconitase
-
beta-decarboxylating
- alpha-ketoadipate
- medicine
- synthesis
Reaction
Synonyms
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating), 2-hydroxy-3-carboxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate dehydrogenase, 3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating), beta-decarboxylating dehydrogenase, dehydrogenase, homoisocitrate, EC 1.1.1.155, HIc, HIc dehydrogenase, HICDH, homoisocitrate dehydrogenase, homoisocitric dehydrogenase, isocitrate-homoisocitrate dehydrogenase, LYS12, protein PH1722, ScHICDH, TK0280
ECTree
Advanced search results
Metals Ions
Metals Ions on EC 1.1.1.87 - homoisocitrate dehydrogenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
K+
Mg2+
Mn2+
additional information
-
selectivity of the activator site for monovalent ions, K+ is the best activator, and NH4+ and Rb+ are also activators of the reaction, while Cs+, Li+, and Na+ are not, overview. Substitution of potassium acetate for KCl changes the kinetic mechanism of HIcDH from a steady state random to a fully ordered mechanism with the binding of Mg-HIc followed by K+ and NAD+
K+
the enzyme requires a potassium ion as an activator, for optimal binding of NAD+
Mg2+
-
stimulation of oxidative decarboxylation, required for reductive carboxylation
Mg2+
-
activates, increase in the affinity of enzyme for Mg-HIc as a result of elimination of the inhibitory effect of Cl-
Mg2+
required, three conserved aspartate residues, D243, D267 and D271, coordinate Mg2+, which is also coordinated to the alpha-carboxylate and alpha-hydroxyl of homoisocitrate
Mg2+
-
Mn2+ or Mg2+ is required for this activity, and stronger activity is observed with Mn2+
Mn2+
-
Mn2+ or Mg2+ is required for this activity, and stronger activity is observed with Mn2+