1.14.13.59: L-lysine N6-monooxygenase (NADPH)

This is an abbreviated version!
For detailed information about L-lysine N6-monooxygenase (NADPH), go to the full flat file.

Reaction

Synonyms

EC 1.13.12.10, EC 13.12.10, flavin-dependent lysine monooxygenase, flavin-dependent N6-lysine monooxygenase, IucD, LH, lysine monooxygenase, Lysine N(6)-hydroxylase, Lysine N6-hydroxylase, lysine N6-monooxygenase, lysine: N6-hydroxylase, lysine:N(6)-hydroxylase, Lysine:N6-hydroxylase, MbsG, N-hydroxylating monooxygenase, NbtG, Oxygenase, lysine N6-mono-

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.59 L-lysine N6-monooxygenase (NADPH)

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Results	in table
4	Activating Compound
6102	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
36	Cofactor
1	Crystallization (Commentary)
4	General Information
1	General Stability
10	Inhibitors
20	kcat/KM [mM/s]
1	Ki Value [mM]
38	KM Value [mM]
5	Localization
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
19	Organism
8	Pathway
4	PDB ID
7	pH Optimum
2	pH Range
25	Protein Variants
4	Purification (Commentary)
5	Reaction
2	Reaction Type
17	Reference
9	Specific Activity [micromol/min/mg]
1	Storage Stability
47	Substrates and Products (Substrate)
5	Subunits
29	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
28	Turnover Number [1/s]

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Turnover Number on EC 1.14.13.59 - L-lysine N6-monooxygenase (NADPH)

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.021 - 0.13

D-Lysine

2 entries

0.243 - 0.731

FAD

9 entries

0.08 - 0.55

L-lysine

6 entries

1.29 - 2.5

NADH

2 entries

0.7 - 2.9

NADPH

8 entries

0.6

O2

Nocardia farcinica

-

pH 7.5, 25°C, recombinant mutant P238R, with NADPH

745322

0.021

D-Lysine

Nocardia farcinica

-

pH 7.5, 25°C, recombinant mutant K64A, with NADH

745322

0.13

D-Lysine

Nocardia farcinica

-

pH 7.5, 25°C, recombinant mutant K64A, with NADPH

745322

0.243

FAD

Escherichia coli

-

mutant C146A, pH 7.0, 37°C

658171

0.305

FAD

Escherichia coli

-

mutant C166A, pH 7.0, 37°C

658171

0.351

FAD

Escherichia coli

-

mutant C31A, pH 7.0, 37°C

658171

0.405

FAD

Escherichia coli

-

wild-type enzyme, pH 7.0, 37°C

658171

0.425

FAD

Escherichia coli

-

mutant C158A, pH 7.0, 37°C

658171

0.543

FAD

Escherichia coli

-

mutant C51A/C158A, pH 7.0, 37°C

658171

0.614

FAD

Escherichia coli

-

mutant C31A/C51A, pH 7.0, 37°C

658171

0.667

FAD

Escherichia coli

-

mutant C51A, pH 7.0, 37°C

658171

0.731

FAD

Escherichia coli

-

mutant C51A/C166A, pH 7.0, 37°C

658171

0.08

L-lysine

Mycolicibacterium smegmatis

-

pH 7.5, 25°C

726965

0.146

L-lysine

Nocardia farcinica

-

pH 7.5, 25°C, recombinant mutant P238R, with NADPH

745322

0.18

L-lysine

Nocardia farcinica

-

pH 7.5, 25°C, recombinant mutant K64A, with NADH

745322

0.34

L-lysine

Nocardia farcinica

-

pH 7.5, 25°C, recombinant mutant K64A, with NADPH

745322

0.43

L-lysine

Mycolicibacterium smegmatis

-

pH 7.5, 25°C, with NADH

744158

0.55

L-lysine

Mycolicibacterium smegmatis

-

pH 7.5, 25°C, with NADPH

744158

1.29

NADH

Nocardia farcinica

-

pH 7.5, 25°C, recombinant wild-type enzyme, with L-Lys

745322

2.5

NADH

Nocardia farcinica

-

pH 7.5, 25°C, recombinant wild-type enzyme, with D-Lys

745322

0.7

NADPH

Nocardia farcinica

Q5Z1T5

pH 7.5, 25°C, cosubstrate L-lysine, mutant enzyme M239R, determined by by measuring oxygen consumption

744167

0.8

NADPH

Nocardia farcinica

Q5Z1T5

pH 7.5, 25°C, cosubstrate L-lysine, mutant enzyme R301A, determined by by measuring oxygen consumption

744167

0.98

NADPH

Nocardia farcinica

Q5Z1T5

pH 7.5, 25°C, cosubstrate L-lysine, mutant enzyme M239R, determined by by measuring oxygen consumption

744167

1.08

NADPH

Nocardia farcinica

Q5Z1T5

pH 7.5, 25°C, cosubstrate L-lysine, wild-type enzyme, determined by by measuring oxygen consumption

744167

1.08

NADPH

Nocardia farcinica

-

pH 7.5, 25°C, recombinant wild-type enzyme, with L-Lys

745322

1.29

NADPH

Nocardia farcinica

Q5Z1T5

pH 7.5, 25°C, cosubstrate L-lysine, wild-type enzyme, determined by by measuring oxygen consumption

744167

2.4

NADPH

Nocardia farcinica

Q5Z1T5

pH 7.5, 25°C, cosubstrate L-lysine, mutant enzyme E216Q, determined by by measuring oxygen consumption

744167

2.9

NADPH

Nocardia farcinica

-

pH 7.5, 25°C, recombinant wild-type enzyme, with D-Lys

745322