1.17.1.4: xanthine dehydrogenase

This is an abbreviated version!
For detailed information about xanthine dehydrogenase, go to the full flat file.

Reaction

Synonyms

AtXDH1, EC 1.1.1.204, EC 1.2.1.37, IAO1, More, NAD-xanthine dehydrogenase, PaoABC, Retinol dehydrogenase, Rosy locus protein, VvXDH, xanthine dehydrogenase, xanthine dehydrogenase-1, xanthine dehydrogenase-2, xanthine dehydrogenase/oxidase, xanthine oxidoreductase, xanthine-NAD oxidoreductase, xanthine/NAD+ oxidoreductase, xanthine:NAD+ oxidoreductase, XDH, XDH/XO, XDH1, XDH2, XdhC, XOR, YagR, YagS, YagT

ECTree

     1 Oxidoreductases

         1.17 Acting on CH or CH₂ groups

             1.17.1 With NAD⁺ or NADP⁺ as acceptor

                1.17.1.4 xanthine dehydrogenase

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Results	in table
22	Activating Compound
13818	AA Sequence
34	Application
1	CAS Registry Number
36	Cloned(Commentary)
299	Cofactor
22	Crystallization (Commentary)
40	Disease/ Diagnostics
3	Expression
84	General Information
9	General Stability
175	Inhibitors
19	kcat/KM [mM/s]
3	Ki Value [mM]
170	KM Value [mM]
22	Localization
133	Metals/Ions
86	Molecular Weight [Da]
237	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
225	Organism
1	Oxidation Stability
14	Pathway
110	PDB ID
45	pH Optimum
8	pH Range
8	pH Stability
1	pI Value
4	Posttranslational Modification
79	Protein Variants
71	Purification (Commentary)
9	Reaction
3	Reaction Type
205	Reference
2	Renatured (Commentary)
217	Source Tissue
65	Specific Activity [micromol/min/mg]
8	Storage Stability
572	Substrates and Products (Substrate)
66	Subunits
107	Synonyms
1	Systematic Name
32	Temperature Optimum [°C]
1	Temperature Range [°C]
22	Temperature Stability [°C]
55	Turnover Number [1/s]

Disease

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Disease on EC 1.17.1.4 - xanthine dehydrogenase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

adenine phosphoribosyltransferase deficiency

[2,8-dihydroxyadenine nephrolithiasis: from diagnosis to therapy]

18039602

Amyotrophic Lateral Sclerosis

Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis.

7570184

Bacterial Infections

Enzymes involved in purine metabolism--a review of histochemical localization and functional implications.

10506947

Carcinoma, Hepatocellular

Decreased concentration of xanthine dehydrogenase (EC 1.1.1.204) in rat hepatomas.

3460692

Chagas Disease

Inhibition of xanthine dehydrogenase from Triatoma infestans by some purine analogues.

3052441

d-xylulose reductase deficiency

The RNAi-Mediated Silencing of Xanthine Dehydrogenase Impairs Growth and Fertility and Accelerates Leaf Senescence in Transgenic Arabidopsis Plants.

17872919

Lung Injury

Effect of hypoxia and reoxygenation on the formation and release of reactive oxygen species by porcine pulmonary artery endothelial cells.

7622587

Lung Injury

Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia. Role in acute lung injury.

9655743

Neoplasms

Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1).

18794327

Neoplasms

Responses of vascular endothelial oxidant metabolism to lipopolysaccharide and tumor necrosis factor-alpha.

1567224

Pneumonia, Viral

Molecular cloning and characterization of the human xanthine dehydrogenase gene (XDH).

8661045

Proteinuria

Renal purine efflux and xanthine oxidase activity during experimental nephrosis in rats: difference between puromycin aminonucleoside and adriamycin nephrosis.

2156648

Pulmonary Edema

Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia. Role in acute lung injury.

9655743

Renal Insufficiency

Molecular cloning and characterization of the human xanthine dehydrogenase gene (XDH).

8661045

Stomach Ulcer

Upregulation of xanthine oxidase by tobacco smoke condensate in pulmonary endothelial cells.

12668123

Vascular System Injuries

Linking uric acid metabolism to diabetic complications.

25512781

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