1.2.1.44: cinnamoyl-CoA reductase This is an abbreviated version! For detailed information about cinnamoyl-CoA reductase, go to the full flat file .
Reaction
cinnamaldehyde +
CoA +
NADP+ =
cinnamoyl-CoA +
NADPH +
H+
Synonyms AtCCR1, BpCCR1, CCR, CCR1, CCR12, CCR14 isoform, CCR17, CCR19, CCR2, CCR2-1, CCR20, CCR21, CCR3, CCR7, CCRH1, cinnamoyl CoA reductase, cinnamoyl CoA reductase 1, cinnamoyl coenzyme A reductase, cinnamoyl-Co-enzyme A reductase, cinnamoyl-CoA reductase, cinnamoyl-CoA reductase 1, cinnamoyl-CoA reductase1, cinnamoyl-CoA reductase2, cinnamoyl-CoA:NADPH reductase, cinnamoyl-coenzyme A reductase, cinnamoyl-coenzyme A reductase 1, FaCCR, feruloyl coenzyme A reductase, feruloyl-CoA reductase, ferulyl-CoA reductase, HcCCR1, HcCCR2, Ll-CCRH1, OsCCR1, p-hydroxycinnamoyl coenzyme A reductase, Ph-CCR1, PtCCR, PtoCCR1, PtoCCR7, PvCCR1, PvCCR2, reductase, cinnamoyl coenzyme A, SbCCR1, SbCCR2-1, SbCCR2-2, Ta-CCR2, VcCCR
ECTree
Inhibitors
Inhibitors on EC 1.2.1.44 - cinnamoyl-CoA reductase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ca2+
-
86% residual activity at 2 mM
caffeoyl-CoA
competitive inhibitor
citraconic anhydride
31% residual activity at 1.5 mM with feruloyl-CoA as substrate
Co2+
-
42% residual activity at 2 mM
CoASH
-
product inhibition
Cs2+
-
83% residual activity at 2 mM
Cu2+
-
49% residual activity at 2 mM
diethylpyrocarbonate
44% residual activity at 3 mM with feruloyl-CoA as substrate
Fe2+
-
92% residual activity at 2 mM
Hg2+
-
complete inhibition at 2 mM
iodoacetamide
-
1 mM, 50% inhibition
Mg2+
-
74% residual activity at 2 mM
Mn2+
-
21% residual activity at 2 mM
N-acetyl imidazole
50% residual activity at 3 mM with feruloyl-CoA as substrate
NADP+
-
product inhibition
Ni2+
-
25% residual activity at 2 mM
Phenylglyoxal
47% residual activity at 1 mM with feruloyl-CoA as substrate
phenylmethylsulfonyl fluoride
60% residual activity at 1 mM with feruloyl-CoA as substrate
S-[2-(acetylamino)ethyl] O-ethyl [(E)-2-(3,4-dimethoxyphenyl)ethenyl]phosphonothioate
-
-
S-[2-(acetylamino)ethyl] O-ethyl [(E)-2-(4-hydroxy-3,5-dimethoxyphenyl)ethenyl]phosphonothioate
-
-
S-[2-(acetylamino)ethyl] O-ethyl [(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]phosphonothioate
-
-
S-[2-(acetylamino)ethyl] O-ethyl [(E)-2-(4-hydroxyphenyl)ethenyl]phosphonothioate
-
-
S-[2-(acetylamino)ethyl] O-ethyl [(E)-2-(4-methoxyphenyl)ethenyl]phosphonothioate
-
-
SDS
-
6% residual activity at 1% (v/v)
sinapoyl-CoA
competitive inhibitor
Woodward's reagent K
54% residual activity at 0.02 mM with feruloyl-CoA as substrate
Zn2+
-
45% residual activity at 2 mM
4-chloromercuribenzoate
-
0.01 mM, 50% inhibition
4-chloromercuribenzoate
-
-
5-hydroxyferuloyl-CoA
substrate inhibition at high concentration above 60 microM; substrate inhibition at high concentration above 60 microM
5-hydroxyferuloyl-CoA
competitive inhibitor
feruloyl-CoA
substrate inhibition at high concentration above 60 microM; substrate inhibition at high concentration above 60 microM
feruloyl-CoA
competitive inhibitor
additional information
not inhibited by N-ethylmaleimide, 4-hydroxymercurybenzoate, and N-bromosuccinimide
-
additional information
-
not inhibited by N-ethylmaleimide, 4-hydroxymercurybenzoate, and N-bromosuccinimide
-
additional information
-
inhibition by antisense strategy alters lignin content and structure
-
additional information
-
inhibition by antisense strategy alters lignin content and structure
-
additional information
the transcript abundance of CCR can be reduced by 35% in transgenic Norway spruce plants expressing antisense CCR. Down-regulation of CCR results in up to 8% lower lignin content and the apparent contribution of H-lignin to the total lignin decreases. The kappa number of small-scale Kraft pulps is reduced in one CCR down-regulated line
-
additional information
-
the transcript abundance of CCR can be reduced by 35% in transgenic Norway spruce plants expressing antisense CCR. Down-regulation of CCR results in up to 8% lower lignin content and the apparent contribution of H-lignin to the total lignin decreases. The kappa number of small-scale Kraft pulps is reduced in one CCR down-regulated line
-
additional information
CCR is more downregulated in colored than in the white zones of stems of transformants
-
additional information
CCR enzyme activity declines dramatically at the heading and milky stages in stems of the C6001 cultivar
-
additional information
-
CCR enzyme activity declines dramatically at the heading and milky stages in stems of the C6001 cultivar
-