2.3.1.168: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase

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For detailed information about dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, go to the full flat file.

Reaction

Synonyms

Bkd, BKDH, DBT, dihydrolipoamide branched chain transacylase, dihydrolipoyl transacetylase, DLD, E2, E2p, More

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.168 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase

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Results	in table
174	AA Sequence
3	Application
13	Cloned(Commentary)
4	General Information
6	Inhibitors
6	KM Value [mM]
7	Localization
7	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
36	Organism
5	Pathway
41	PDB ID
1	pH Optimum
3	Protein Variants
8	Purification (Commentary)
4	Reaction
1	Reaction Type
34	Reference
4	Renatured (Commentary)
13	Source Tissue
5	Specific Activity [micromol/min/mg]
49	Substrates and Products (Substrate)
24	Subunits
34	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

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Application on EC 2.3.1.168 - dihydrolipoyllysine-residue (2-methylpropanoyl)transferase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

agriculture

Oryza sativa Indica Group

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mutation of promoter binding protein SPL16/GW8 leads to upregulation of pyruvate kinase, pyruvate dehydrogenase E1, dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial pyruvate carrier, 4-hydroxyphenylpyruvate dioxygenase, and dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. SPL16 mutations have the potential to boost the grain yield of rice

763158

medicine

Drosophila melanogaster

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creation of a Drosophila model of maple syrup urine disease MSUD by knocking out the DBT gene, an ortholog of the human gene encoding the dihydrolipoamide branched chain transacylase (DBT) subunit of BCKDH. The homozygous DBT mutant larvae recapitulate an array of MSUD phenotypes, including aberrant branched-chain amino acid accumulation, developmental defects, poor mobile behavior and disrupted L-glutamate homeostasis. The DBT mutation causes neuronal apoptosis during the developmental progression of larval brains and severe impairment of retinal rhabdomeres. The DBT mutant shows elevated oxidative stress and higher lipid peroxidation accumulation in the larval brain. When the DBT mutants are administrated with antidiabetic drug metformin, the aberrances in branched-chain amino acid levels and motor behavior are ameliorated

762953

synthesis

Streptomyces avermitilis

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functional expression of the branched chain alpha-keto acid dehydrogenase complex in Escherichia coli by independent and selective optimization of individual subunit genes of the complex. Codon optimization significantly improves the expression of complex component proteins BkdH and LpdA1 but expression of dehydrogenase E1 alpha subunit BkdF and dehydrogenase E1 beta subunit BkdG depends on coexpression of the BkdH gene. The optimized branched chain alpha-keto acid dehydrogenase complex supplies sufficient short branched-chain acyl-CoA to synthesize phlorisovalerophenone

762852