2.3.1.168: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
This is an abbreviated version!
For detailed information about dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, go to the full flat file.
Word Map on EC 2.3.1.168
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2.3.1.168
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branched-chain
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bcaas
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merits
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protein-restricted
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retinal
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urine
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metformin
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women
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maple
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l-glutamate
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syrup
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agriculture
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synthesis
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medicine
- 2.3.1.168
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branched-chain
-
bcaas
-
merits
-
protein-restricted
- retinal
- urine
- metformin
- women
-
maple
- l-glutamate
- syrup
- agriculture
- synthesis
- medicine
Reaction
Synonyms
Bkd, BKDH, DBT, dihydrolipoamide branched chain transacylase, dihydrolipoyl transacetylase, DLD, E2, E2p, More
ECTree
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General Information
General Information on EC 2.3.1.168 - dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
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physiological function
branched-chain amino acids are metabolized within both the vasculature and neurons in the human brain. Glutamate dehydrogenase isozymes, branched-chain aminotransferase and the branched-chain alpha-ketoacid dehydrogenase proteins may operate in conjunction with astrocytic glutamate transporters and glutamine synthetase to regulate the availability of glutamate
physiological function
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branched-chain fatty acids make up 50% of membrane fatty acids in wild-type but only 31% in the branched-chain alpha-keto acid dehydrogenase BKD-deficient mutant. Branched-chain fatty acids level is about 80% in the pyruvate dehydrogenase PDH-deficient strain and 38% in the BKD:pruvate dehydrogenase-deficient strain. BKD-deficient mutants show decreased membrane fluidity,while the PDH-deficient mutant shows increased membrane fluidity. The BKD- and PDH-deficient strains grow slower and the BKD:PDH-deficient strain grows slowest at 37°C. The BKD-deficient strain produces higher levels of staphyloxanthin. The PDH-deficient and BKD:PDH-deficient strains produce very little staphyloxanthin. The BKD-deficient strain shows increased susceptibility to daptomycin
physiological function
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mutation of promoter binding protein SPL16/GW8 leads to upregulation of pyruvate kinase, pyruvate dehydrogenase E1, dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial pyruvate carrier, 4-hydroxyphenylpyruvate dioxygenase, and dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. SPL16 mutations have the potential to boost the grain yield of rice
physiological function
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branched-chain fatty acids make up 50% of membrane fatty acids in wild-type but only 31% in the branched-chain alpha-keto acid dehydrogenase BKD-deficient mutant. Branched-chain fatty acids level is about 80% in the pyruvate dehydrogenase PDH-deficient strain and 38% in the BKD:pruvate dehydrogenase-deficient strain. BKD-deficient mutants show decreased membrane fluidity,while the PDH-deficient mutant shows increased membrane fluidity. The BKD- and PDH-deficient strains grow slower and the BKD:PDH-deficient strain grows slowest at 37°C. The BKD-deficient strain produces higher levels of staphyloxanthin. The PDH-deficient and BKD:PDH-deficient strains produce very little staphyloxanthin. The BKD-deficient strain shows increased susceptibility to daptomycin
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