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2.3.2.21: cyclo(L-tyrosyl-L-tyrosyl) synthase

This is an abbreviated version!
For detailed information about cyclo(L-tyrosyl-L-tyrosyl) synthase, go to the full flat file.

Reaction

2 L-tyrosyl-tRNATyr = 2 tRNATyr +

cyclo(L-tyrosyl-L-tyrosyl)

Synonyms

CDPS, CDPS-Np, cyclo(L-tyrosyl-L-tyrosyl) synthase, cyclodipeptide synthase, cyclodityrosine synthetase, cYY synthase, Rv2275

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.21 cyclo(L-tyrosyl-L-tyrosyl) synthase

Cloned

Cloned on EC 2.3.2.21 - cyclo(L-tyrosyl-L-tyrosyl) synthase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene Rv2275, recombinant expression in Escherichia coli strain BL21AI, subcloning in Escherichia coli strain DH5alpha
recombinant overexpression of His-tagged wild-type and mutant enzymes in Escherichia coli resulted in the formation of cyclo-(L-Tyr-L-Tyr) as the minor and cyclo-(L-Tyr-L-Phe) as the major products
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