2.4.1.145: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase This is an abbreviated version! For detailed information about alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, go to the full flat file .
Word Map on EC 2.4.1.145
Reaction
UDP-N-acetyl-alpha-D-glucosamine +
beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] =
UDP +
beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
Synonyms (GnT)-IVa, (GnT)-IVb, alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase, alpha1,3-mannosyl-beta1,4-N-acetylglucosaminyltransferase IV, beta-acetylglucosaminyltransferase IV, EC 2.4.1.51, GlcNAcTase-IV, GnT IV, GnT-IV, GnT-IVa, GnT-IVb, GnTIVa, Mgat4a, Mgat4b, N-acetylglucosaminyltransferase IV, N-acetylglucosaminyltransferase IVa, N-acetylglucosaminyltransferase-IV, N-acetylglucosaminyltransferase-IVa, N-acetylglucosaminyltransferase-IVb, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV, uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV
ECTree
Systematic Name
Systematic Name on EC 2.4.1.145 - alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
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UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Requires Mn2+. The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus. By adding a glucosaminyl residue to biantennary N-linked glycans, it enables the synthesis of tri- and tetra-antennary complexes.