2.4.1.80: ceramide glucosyltransferase

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For detailed information about ceramide glucosyltransferase, go to the full flat file.

Reaction

Synonyms

ceramide glucosyltransferase, ceramide glycosyltransferase, ceramide:UDP-glucose glucosyltransferase, ceramide:UDPGlc glucosyltransferase, cerebroside synthase, CGT, cgt-1, cgt-2, cgt-3, GCS, GCS1, GlcCer synthase, GlcCerS, GlcT, GlcT-1, glucosylceramide synthase, glucosyltransferase, uridine diphosphoglucose-ceramide, GluT, UDP glucose-ceramide glucosyltransferase, UDP-Glc:ceramide glucosyltransferase, UDP-glucoase:ceramide glucosyltransferase, UDP-glucose ceramide glucosyltransferase, UDP-glucose ceramide glycosyltransferase, UDP-glucose: ceramide glucosyltransferase, UDP-glucose:ceramide glucosyltransferase, Ugcg, uridine diphosphate (UDP)-glucose:N-acylsphingosine D-glucosyltransferase, uridine diphosphoglucose-ceramide glucosyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.80 ceramide glucosyltransferase

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Results	in table
24	Activating Compound
3411	AA Sequence
12	Application
1	CAS Registry Number
26	Cloned(Commentary)
64	Disease/ Diagnostics
11	Expression
18	General Information
5	General Stability
135	IC50 Value
208	Inhibitors
1	Ki Value [mM]
13	KM Value [mM]
37	Localization
27	Metals/Ions
27	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
419	Organism
7	Pathway
28	pH Optimum
1	pH Range
36	Protein Variants
9	Purification (Commentary)
4	Reaction
1	Reaction Type
90	Reference
2	Renatured (Commentary)
104	Source Tissue
30	Specific Activity [micromol/min/mg]
3	Storage Stability
152	Substrates and Products (Substrate)
8	Subunits
133	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
1	Temperature Range [°C]

Expression

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Expression on EC 2.4.1.80 - ceramide glucosyltransferase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

after 17 h under a 42°C heat stress, GluT mRNA increased to 142%

Chlorocebus sabaeus

-

703917

after 24 h under a 42°C heat stress, GluT mRNA significantly increased to 714%

Canis lupus familiaris

-

703917

cell culture under 42°C heat stress for 17 h, increase of gene expression to 142%

Chlorocebus aethiops

-

703917

cell culture under 42°C heat stress for 24 h, increase of gene expression to 714%

Canis lupus familiaris

-

703917

glucosylceramide synthase expression is enhanced in breast cancer stem cells but not in normal mammary epithelial stem cells

Homo sapiens

-

722787

HSP70 influence on gene expression

2 entries

in the absence of p53, mitomycin C treatment elicits a down-regulation of the enzyme

Homo sapiens

-

721726

the mixed-backbone oligonucleotide MBO-asGCS considerable decreases mRNA levels in murine tumor cell lines

Mus musculus

-

706417

the mixed-backbone oligonucleotide MBO-asGCS decreases mRNA levels in human tumor cell lines by 65%

Homo sapiens

-

706417

Vinca alkaloid vinorelbine induces the enzyme in vinorelbine-resitant cells

Homo sapiens

Q16739

736920

HSP70 influence on gene expression

Canis lupus familiaris

-

703917

HSP70 influence on gene expression

Chlorocebus aethiops

-

703917