2.4.1.83: dolichyl-phosphate beta-D-mannosyltransferase

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For detailed information about dolichyl-phosphate beta-D-mannosyltransferase, go to the full flat file.

Reaction

Synonyms

AglD, bDPM1, D-P-M, Dol-P Man synthase, Dol-P-Man synthase, Dol-P-Man synthase1, Dol-P-Man-synthase, Dol-P-Mansynthase, Dol-PMan synthase, dolichol phosphate mannose synthase, dolichol phosphoryl mannose synthase, dolichol-P-mannose synthase, dolicholphosphate mannose synthase, dolichyl mannosyl phosphate synthase, dolichyl phosphate mannosyltransferase, dolichyl-phosphate mannose synthase, dolichyl-phosphate mannosyltransferase, dolichyl-phospho-mannose synthase, dolichylphosphate mannose synthase, DPM, DPM synthase, DPM1, DPMS, DPMS1, GDP-Man:DolP mannosyltransferase, GDP-mannose-dolichol phosphate mannosyltransferase, GDPMan:DolP mannosyltransferase, GDPmannose-dolichylmonophosphate mannosyltransferase, GDPmannose:dolichyl-phosphate mannosyltransferase, mannosylphospho dolichol synthase, mannosylphosphodolichol synthase, mannosylphosphoryldolichol synthase, mannosyltransferase, guanosine diphosphomannose-dolichol phosphate, MPD synthase, PF0058, Pfdpm1, PfDPMS, PH0051

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase

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Results	in table
17	Activating Compound
5205	AA Sequence
4	Application
1	CAS Registry Number
16	Cloned(Commentary)
2	Crystallization (Commentary)
22	Disease/ Diagnostics
3	Expression
28	General Information
4	General Stability
53	Inhibitors
7	Ki Value [mM]
39	KM Value [mM]
33	Localization
23	Metals/Ions
6	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
67	Organism
9	Pathway
12	pH Optimum
2	pH Range
5	Posttranslational Modification
18	Protein Variants
16	Purification (Commentary)
6	Reaction
1	Reaction Type
62	Reference
27	Source Tissue
7	Specific Activity [micromol/min/mg]
8	Storage Stability
78	Substrates and Products (Substrate)
9	Subunits
77	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Temperature Stability [°C]
9	Turnover Number [1/s]

Expression

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Expression on EC 2.4.1.83 - dolichyl-phosphate beta-D-mannosyltransferase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

capillary endothelial cells harboring DPMS overexpressing plasmid express DPMS higher than pEGFP-N1 vector and the parental cells

Bos taurus

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703922

compared with the mock line, the temporary PEC(Z)/PB lines show a decreased mRNA expression for D-P-M and a clear destruction of porcine endogenous retrovirus infectivity to human cells in the Lac Z pseudotype assay. Compared with parental and mock cells, all PEC(Z)/PB cells transfected with siRNA show a decreased mRNA expression for the D-P-M by one-fifth

Sus scrofa

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706862

the DPMS-overexpressing clone has a high level of DPMS mRNA, expresses nearly 4times more DPMS protein than the clone transfected with pEGFP-N1 vector only and has 108% higher DPMS activity than the vector control

synthetic construct

-

702004