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2.5.1.59: protein geranylgeranyltransferase type I

This is an abbreviated version!
For detailed information about protein geranylgeranyltransferase type I, go to the full flat file.

Word Map on EC 2.5.1.59

Reaction

geranylgeranyl diphosphate
+
protein-cysteine
=
S-geranylgeranyl-protein
 +
diphosphate

Synonyms

CAAX geranylgeranyltransferase, CaaX prenyltransferase, CaGGTase-I, CDC43, geranylgeranyl protein transferase type I, geranylgeranyltransferase I, geranylgeranyltransferase type I, geranylgeranyltransferase type-I, geranylgeranyltransferase-1, geranylgeranyltransferase-I, geranylgeranyltransferaseI, GGT, GGT I, GGTalpha, GGTase, GGTase I, Ggtase-1, GGTase-I, GGTaseI, GGTbeta, GGTI, mammalian GGTase-I, PGGT, PGGT beta, PGGT I, PGGT-I, PGGTase-I, PGGTaseI, Ppggb, protein geranylgeranyltransferase, protein geranylgeranyltransferase I, protein geranylgeranyltransferase type I, protein geranylgeranyltransferase type-I, protein geranylgeranyltransferase-I, type I protein geranylgeranyltransferase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.59 protein geranylgeranyltransferase type I

Turnover Number

Turnover Number on EC 2.5.1.59 - protein geranylgeranyltransferase type I

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.028 - 0.12
(biotin-CONH-(CH2)5-CO-)-NPFREKKFFCAI-Leu
0.08
3,7,11-trimethyl-12-(7-nitro-benzo[1,2,5]-oxadiazo-4-ylamino)-dodeca-2,6,10-trien-1-diphosphate
-
-
0.021
Asp-Asp-Pro-Thr-Ala-Ser-Ala-Cys-Val-Leu-Leu
-
at 30°C
0.02 - 0.34
geranylgeranyl diphosphate
0.0057
GST-CDC42
-
prenyl donor: geranylgeranyl diphosphate
-
0.08
GST-RhoA
-
-
-
0.0667
Ki-Ras4A
-
-
-
0.0767
Ki-Ras4B
-
-
-
0.0113
N-Ras
-
-
-
0.014 - 0.02
Ras-Cys-Val-Leu-Leu
0.001
Thr-Lys-Cys-Val-Ile-Ala
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.001
Thr-Lys-Cys-Val-Ile-Arg
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.001
Thr-Lys-Cys-Val-Ile-Asn
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.001
Thr-Lys-Cys-Val-Ile-Asp
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.0063
Thr-Lys-Cys-Val-Ile-Cys
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.001
Thr-Lys-Cys-Val-Ile-Gln
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.048
Thr-Lys-Cys-Val-Ile-Ile
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.088
Thr-Lys-Cys-Val-Ile-Leu
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.082
Thr-Lys-Cys-Val-Ile-Met
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.06
Thr-Lys-Cys-Val-Ile-Phe
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.001
Thr-Lys-Cys-Val-Ile-Ser
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.001
Thr-Lys-Cys-Val-Ile-Thr
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.022
Thr-Lys-Cys-Val-Ile-Tyr
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
0.107
Thr-Lys-Cys-Val-Ile-Val
-
in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2
additional information
additional information
-