2.5.1.59: protein geranylgeranyltransferase type I
This is an abbreviated version!
For detailed information about protein geranylgeranyltransferase type I, go to the full flat file.
Word Map on EC 2.5.1.59
-
2.5.1.59
-
geranylgeranylation
-
prenylation
-
farnesyltransferase
-
farnesylation
-
ftase
-
isoprenoids
-
prenyltransferases
-
gtpases
-
rhoa
-
peptidomimetic
-
rab
-
mevalonate
-
isoprenylation
-
ggtis
-
h-ras
-
geranylgeraniol
-
farnesylpyrophosphate
-
rap1a
-
lovastatin
-
geranylgeranylpyrophosphate
-
20-carbon
-
escort
-
medicine
-
molecular biology
-
k-ras4b
-
pharmacology
- 2.5.1.59
-
geranylgeranylation
-
prenylation
-
farnesyltransferase
-
farnesylation
- ftase
-
isoprenoids
- prenyltransferases
- gtpases
- rhoa
-
peptidomimetic
- rab
- mevalonate
-
isoprenylation
-
ggtis
- h-ras
- geranylgeraniol
-
farnesylpyrophosphate
- rap1a
- lovastatin
-
geranylgeranylpyrophosphate
-
20-carbon
-
escort
- medicine
- molecular biology
- k-ras4b
- pharmacology
Reaction
Synonyms
CAAX geranylgeranyltransferase, CaaX prenyltransferase, CaGGTase-I, CDC43, geranylgeranyl protein transferase type I, geranylgeranyltransferase I, geranylgeranyltransferase type I, geranylgeranyltransferase type-I, geranylgeranyltransferase-1, geranylgeranyltransferase-I, geranylgeranyltransferaseI, GGT, GGT I, GGTalpha, GGTase, GGTase I, Ggtase-1, GGTase-I, GGTaseI, GGTbeta, GGTI, mammalian GGTase-I, PGGT, PGGT beta, PGGT I, PGGT-I, PGGTase-I, PGGTaseI, Ppggb, protein geranylgeranyltransferase, protein geranylgeranyltransferase I, protein geranylgeranyltransferase type I, protein geranylgeranyltransferase type-I, protein geranylgeranyltransferase-I, type I protein geranylgeranyltransferase
ECTree
2.5.1.59 protein geranylgeranyltransferase type IAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.5.1.59 - protein geranylgeranyltransferase type I
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3,7,11-trimethyl-12-(7-nitro-benzo[1,2,5]-oxadiazo-4-ylamino)-dodeca-2,6,10-trien-1-diphosphate + GST-RhoA
diphosphate + ?
-
-
-
-
?
3,7-dimethyl-8-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-octa-2,6-diene-1-diphosphate + GST-RhoA
diphosphate + ?
-
-
-
-
?
farnesyl diphosphate + (biotin-CONH-(CH2)5-CO-)-NPFREKKFFCAI-Leu
diphosphate + (biotin-CONH-(CH2)5-CO-)-NPFREKKFF-S-farnesyl-CAI-Leu
farnesyl diphosphate + Ki-Ras4B
diphosphate + S-geranylgeranyl-Ki-Ras4B
-
-
-
-
?
geranylgeranyl diphosphate + (biotin-CONH-(CH2)5-CO-)-ALEPPETEPKRKCCIF
diphosphate + (biotin-CONH-(CH2)5-CO-)-ALEPPETEPKRK-S-geranylgeranyl-CCIF
geranylgeranyl diphosphate + (biotin-CONH-(CH2)5-CO-)-GTPRASNRSCAIS
diphosphate + (biotin-CONH-(CH2)5-CO-)-GTPRASNRS-S-geranylgeranyl-CAIS
-
ECB-laminB(S), 5% activity in comparison of protein substrate motif: CAA-leucine
-
-
?
geranylgeranyl diphosphate + (biotin-CONH-(CH2)5-CO-)-NPFREKKFFCAI-Leu
diphosphate + (biotin-CONH-(CH2)5-CO-)-NPFREKKFF-S-geranylgeranyl-CAI-Leu
geranylgeranyl diphosphate + Arg-Arg-Cys-Val-Leu-Leu
diphosphate + Arg-Arg-S-geranylgeranyl-Cys-Val-Leu-Leu
-
-
-
-
?
geranylgeranyl diphosphate + Asp-Asp-Pro-Thr-Ala-Ser-Ala-Cys-Val-Leu-Leu
Asp-Asp-Pro-Thr-Ala-Ser-Ala-(S-geranylgeranyl)-Cys-Val-Leu-Leu + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + Cdc420-cysteine
S-geranylgeranyl-Cdc420 + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Cys-Val-Leu-Leu
S-geranylgeranyl-Cys-Val-Leu-Leu + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + Cys-Val-Leu-Ser
S-geranylgeranyl-Cys-Val-Leu-Ser + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + dansyl-Cys-Ile-Ile-Leu
diphosphate + dansyl-S-geranylgeranyl-Cys-Ile-Ile-Leu
-
-
-
-
?
geranylgeranyl diphosphate + dansyl-GCFT
diphosphate + S-geranylgeranyl dansyl-GCFT
-
-
-
?
geranylgeranyl diphosphate + dansyl-GCII
diphosphate + S-geranylgeranyl dansyl-GCII
-
-
-
?
geranylgeranyl diphosphate + dansyl-GCLL
diphosphate + S-geranylgeranyl dansyl-GCLL
-
-
-
?
geranylgeranyl diphosphate + dansyl-GCYL
diphosphate + S-geranylgeranyl dansyl-GCYL
-
-
-
?
geranylgeranyl diphosphate + dansyl-Gly-Cys-Ile-Ile-Leu
dansyl-Gly-(S-geranylgeranyl)-Cys-Ile-Ile-Leu + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + dansyl-Thr-Lys-Cys-Val-Ile-Met
diphosphate + dansyl-Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Met
-
-
-
-
?
geranylgeranyl diphosphate + GST-CDC42
diphosphate + GST-S-geranylgeranyl-CDC42
-
recombinant glutathione S-transferase fusion protein of CDC42Hs with a C-terminal Cys-Cys-Ile-Phe sequence
-
-
?
geranylgeranyl diphosphate + GST-RhoA
diphosphate + GST-S-geranylgeranyl-RhoA
-
-
-
-
?
geranylgeranyl diphosphate + Ki-Ras4A
diphosphate + S-geranylgeranyl-Ki-Ras4A
-
-
-
-
?
geranylgeranyl diphosphate + Leu-Pro-Cys-Val-Val-Met
diphosphate + Leu-Pro-S-geranylgeranyl-Cys-Val-Val-Met
-
-
-
-
?
geranylgeranyl diphosphate + Lys-Lys-Cys-Ile-Ile-Met
diphosphate + Lys-Lys-S-geranylgeranyl-Cys-Ile-Ile-Met
-
-
-
-
?
geranylgeranyl diphosphate + Lys-Pro-Cys-Val-Val-Met
Lys-Pro-(S-geranylgeranyl)-Cys-Val-Val-Met + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + N-Ras
diphosphate + S-geranylgeranyl-N-Ras
-
-
-
-
?
geranylgeranyl diphosphate + Phe-Phe-Cys-Ala-Ile-Leu
diphosphate + Phe-Phe-S-geranylgeranyl-Cys-Ala-Ile-Leu
-
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl protein + diphosphate
-
the enzyme catalyzes posttranslational modification of proteins, the farnesyl moieties attached to the substrates are direcly involved in protein-protein interactions as well as in protein-membrane interactions
-
-
?
geranylgeranyl diphosphate + Rac GTPase-cysteine
S-geranylgeranyl-Rac GTPase + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Ras-CVLL
S-geranylgeranyl-Ras-CVLL + diphosphate
-
tritium labelled geranylgeranyl diphosphate for enzyme assay, His-tagged geranylgeranyl diphosphate
-
-
?
geranylgeranyl diphosphate + Ras-Cys-Val-Leu-Leu
diphosphate + Ras-S-geranylgeranyl-Cys-Val-Leu-Leu
geranylgeranyl diphosphate + Rho GTPase-cysteine
S-geranylgeranyl-Rho GTPase + diphosphate
geranylgeranyl diphosphate + RhoA GTPase-cysteine
S-geranylgeranyl-RhoA GTPase + diphosphate
-
-
-
?
geranylgeranyl diphosphate + rhoC protein
S-geranylgeranyl-protein + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + S-geranylgeranyl-Ki-Ras4B
diphosphate + S-geranylgeranyl-Ki-Ras4B
-
both the polylysine and the carboxy-terminal methionine are important for geranylgeranylation of this substrate
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Ala
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Ala
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Arg
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Arg
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Asn
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Asn
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Asp
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Asp
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Cys
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Cys
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Gln
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Gln
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Ile
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Ile
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Leu
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Leu
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Met
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Met
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Phe
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Phe
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Ser
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Ser
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Thr
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Thr
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Tyr
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Tyr
-
-
-
-
?
geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Val
diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Val
-
-
-
-
?
Ser-Ser-Cys-Ile-Leu-Leu + geranylgeranyl diphosphate
diphosphate + Ser-Ser-S-geranylgeranyl-Cys-Ile-Leu-Leu
-
-
-
-
?
farnesyl diphosphate + (biotin-CONH-(CH2)5-CO-)-NPFREKKFFCAI-Leu
diphosphate + (biotin-CONH-(CH2)5-CO-)-NPFREKKFF-S-farnesyl-CAI-Leu
-
biotin-gamma6
-
-
?
farnesyl diphosphate + (biotin-CONH-(CH2)5-CO-)-NPFREKKFFCAI-Leu
diphosphate + (biotin-CONH-(CH2)5-CO-)-NPFREKKFF-S-farnesyl-CAI-Leu
-
ECB-gamma6
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
the enzyme catalyzes postttranslational modification of proteins, the farnesyl moieties attached to the substrates are direcly involved in protein-protein interactions as well as in protein-membrane interactions
-
-
?
farnesyl diphosphate + protein-cysteine
S-farnesyl protein + diphosphate
-
substrate motif: carboxy-terminal -Ca1a2X box
-
-
?
geranylgeranyl diphosphate + (biotin-CONH-(CH2)5-CO-)-ALEPPETEPKRKCCIF
diphosphate + (biotin-CONH-(CH2)5-CO-)-ALEPPETEPKRK-S-geranylgeranyl-CCIF
-
-
-
-
?
geranylgeranyl diphosphate + (biotin-CONH-(CH2)5-CO-)-ALEPPETEPKRKCCIF
diphosphate + (biotin-CONH-(CH2)5-CO-)-ALEPPETEPKRK-S-geranylgeranyl-CCIF
-
ECB-G25K, 42% activity in comparison of protein substrate motif: CAA-leucine
-
-
?
geranylgeranyl diphosphate + (biotin-CONH-(CH2)5-CO-)-NPFREKKFFCAI-Leu
diphosphate + (biotin-CONH-(CH2)5-CO-)-NPFREKKFF-S-geranylgeranyl-CAI-Leu
-
biotin-gamma6, preferred substrate
-
-
?
geranylgeranyl diphosphate + (biotin-CONH-(CH2)5-CO-)-NPFREKKFFCAI-Leu
diphosphate + (biotin-CONH-(CH2)5-CO-)-NPFREKKFF-S-geranylgeranyl-CAI-Leu
-
ECB-gamma6, preferred substrate
-
-
?
geranylgeranyl diphosphate + Cdc42-cysteine
S-geranylgeranyl-Cdc42 + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Cdc42-cysteine
S-geranylgeranyl-Cdc42 + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Cdc42-cysteine
S-geranylgeranyl-Cdc42 + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Cdc42-cysteine
S-geranylgeranyl-Cdc42 + diphosphate
-
-
-
?
geranylgeranyl diphosphate + K Ras-cysteine
S-geranylgeranyl-K Ras + diphosphate
-
-
-
?
geranylgeranyl diphosphate + K Ras-cysteine
S-geranylgeranyl-K Ras + diphosphate
-
-
-
?
geranylgeranyl diphosphate + Ki-Ras4B
diphosphate + S-geranylgeranyl-Ki-Ras4B
-
-
-
-
?
geranylgeranyl diphosphate + Ki-Ras4B
diphosphate + S-geranylgeranyl-Ki-Ras4B
-
-
-
-
?
geranylgeranyl diphosphate + N-Ras-cysteine
S-geranylgeranyl-N-Ras + diphosphate
-
-
-
?
geranylgeranyl diphosphate + N-Ras-cysteine
S-geranylgeranyl-N-Ras + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
the enzyme negatively regulates abscisic acid signaling in guard cells. The enzyme is specifically involved in negative regulation of auxin-induced lateral root initiation
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-Leu
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X. X is Leu, Phe or Ser, preferred substrate: Leu
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X. X is Leu, Phe or Ser, preferred substrate: Leu
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X. X may be Leu, Phe, or Ser, with high concentrations of peptide substrates this specificity is lost
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme catalyses the transfer of the 20-carbon prenyl group from geranylgeranyl diphosphate to the cysteine residue near the C-termini of a variety of eukaryotic proteins
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-Leu
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
substrate motif: carboxy-terminal -Ca1a2X box
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
the enzyme adds a C20 geranylgeranyl group to proteins such as RhoA, RhoC, Rap1 and Ral at the cysteine within the carboxy-terminal tetrapeptide consensus sequence CAAL (C is cysteine, A is an aliphatic amino acid, and the C-terminal residue is leucine or phenylalanine)
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
the Rab protein Rab8-GTPase, which ends with a Cys-Val-Leu-Leu motif is able to serve as a substrate for either geranylgeranyl transferase I and II, but modified predominantly by geranylgeranyl transferase II, Y78D mutation selective prevents prenylation of Rab8 by geranylgeranyl transferase II, but not geranylgeranyltransferaseI
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
prenylation, substrates are Rho, Rac, most trimeric G protein gamma subunits
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X. X is Leu, Phe or Ser, preferred substrate: Leu
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
GGTase-I catalyzes C-terminal lipidation of more than 100 proteins, including many GTP-binding regulatory proteins
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
-
-
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-Leu
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-Leu
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-Leu
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
prenylation, substrates are Rho, Rac, most trimeric G protein gamma subunits
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
prenylation, substrates are Rho, Rac, most trimeric G protein gamma subunits
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
prenylation, substrates are Rho, Rac, most trimeric G protein gamma subunits
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
prenylation, substrates are Rho, Rac, most trimeric G protein gamma subunits
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
prenylation, substrates are Rho, Rac, most trimeric G protein gamma subunits
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
prenylation, substrates are Rho, Rac, most trimeric G protein gamma subunits
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X. X is Leu or Phe
-
?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
-
enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X. X is Leu or Phe
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?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X
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?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X
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?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X
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?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X
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?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X
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?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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this prenylation is necessary for many proteins to interact with membrane localized at proper intracellular sites
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?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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yeast enzyme is essential for yeast cell growth
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?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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enzyme requires that protein substrates contain a Cys residue fourth from the C terminus, protein substrate motif: Cys-aliphatic-aliphatic-X
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?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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this prenylation is necessary for many proteins to interact with membrane localized at proper intracellular sites
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?
geranylgeranyl diphosphate + protein-cysteine
S-geranylgeranyl-protein + diphosphate
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-
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?
geranylgeranyl diphosphate + Rac-cysteine
S-geranylgeranyl-Rac + diphosphate
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-
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?
geranylgeranyl diphosphate + Rac-cysteine
S-geranylgeranyl-Rac + diphosphate
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-
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?
geranylgeranyl diphosphate + Rac-cysteine
S-geranylgeranyl-Rac + diphosphate
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-
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?
geranylgeranyl diphosphate + Rac-cysteine
S-geranylgeranyl-Rac + diphosphate
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-
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?
geranylgeranyl diphosphate + Rap-cysteine
S-geranylgeranyl-Rap + diphosphate
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-
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?
geranylgeranyl diphosphate + Rap-cysteine
S-geranylgeranyl-Rap + diphosphate
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-
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?
geranylgeranyl diphosphate + Rap1A-cysteine
S-geranylgeranyl-Rap1A + diphosphate
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-
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?
geranylgeranyl diphosphate + Rap1A-cysteine
S-geranylgeranyl-Rap1A + diphosphate
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-
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?
geranylgeranyl diphosphate + Rap1A-cysteine
S-geranylgeranyl-Rap1A + diphosphate
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-
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?
geranylgeranyl diphosphate + Rap1A-cysteine
S-geranylgeranyl-Rap1A + diphosphate
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-
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?
geranylgeranyl diphosphate + Ras protein
S-geranylgeranyl-Ras protein + diphosphate
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-
-
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?
geranylgeranyl diphosphate + Ras protein
S-geranylgeranyl-Ras protein + diphosphate
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-
-
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?
geranylgeranyl diphosphate + Ras-Cys-Val-Leu-Leu
diphosphate + Ras-S-geranylgeranyl-Cys-Val-Leu-Leu
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-
-
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?
geranylgeranyl diphosphate + Ras-Cys-Val-Leu-Leu
diphosphate + Ras-S-geranylgeranyl-Cys-Val-Leu-Leu
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-
-
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?
geranylgeranyl diphosphate + Rho GTPase-cysteine
S-geranylgeranyl-Rho GTPase + diphosphate
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-
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?
geranylgeranyl diphosphate + Rho GTPase-cysteine
S-geranylgeranyl-Rho GTPase + diphosphate
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-
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?
geranylgeranyl diphosphate + Rho-cysteine
S-geranylgeranyl-Rho + diphosphate
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-
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?
geranylgeranyl diphosphate + Rho-cysteine
S-geranylgeranyl-Rho + diphosphate
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-
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?
geranylgeranyl diphosphate + Rho10-cysteine
S-geranylgeranyl-Rho10 + diphosphate
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-
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?
geranylgeranyl diphosphate + Rho10-cysteine
S-geranylgeranyl-Rho10 + diphosphate
while Rho10 has benn previously predicted to lack a CaaX motif, analysis of the Rho10 transcript sequence using RNA sequencing data reveals that one splice site is misannotated, the corrected sequence contains a CLIL C-terminal motif
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?
geranylgeranyl diphosphate + [glutathione S-transferase]-GCVKIKKCVIL
diphosphate + ?
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-
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?
geranylgeranyl diphosphate + [glutathione S-transferase]-GCVKIKKCVIL
diphosphate + ?
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?
additional information
?
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the enzyme has a restricted substrate specificity. Ggtase-I substrates often contain CaaL motifs, overview. Of the three Rho paralogues, only GFP-Rho10 localizes to cellular membranes in wild-type cells. This membrane localization is slightly disrupted in the cdc43DELTA mutant, indicating that the Rho10 protein is likely a Ggtase-I substrate
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?
additional information
?
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the enzyme has a restricted substrate specificity. Ggtase-I substrates often contain CaaL motifs, overview. Of the three Rho paralogues, only GFP-Rho10 localizes to cellular membranes in wild-type cells. This membrane localization is slightly disrupted in the cdc43DELTA mutant, indicating that the Rho10 protein is likely a Ggtase-I substrate
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?
additional information
?
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GGTase-I can transfer isoprenoids to intracellular proteins that contain CAAX motifs. The isoprenoid groups can be selectively recognized by GGTase-I. The 20-carbon isoprenoid geranylgeranyl from its donor geranylgeranyl diphosphate (GGPP) is specific to GGTase-I. No activity with H-Ras
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?
additional information
?
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GGTase-I can transfer isoprenoids to intracellular proteins that contain CAAX motifs. The isoprenoid groups can be selectively recognized by GGTase-I. The 20-carbon isoprenoid geranylgeranyl from its donor geranylgeranyl diphosphate (GGPP) is specific to GGTase-I. No activity with H-Ras
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?
additional information
?
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some of the 18 analysed hexapeptides effieciently farnsylated by enzyme
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?
additional information
?
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the enzyme modifies proteins by attaching a 20-carbon isoprenoid group to a cysteine residue near the C-terminus of a target protein. The enzyme requires a C-terminal Ca1a2X sequence on its substrates, with the a1, a2, and X residues serving as substrate-recognition elements for GGTase-I. Crystallographic structures of rat GGTase-I show a tightly packed and hydrophobic a2 residue binding pocket, consistent with a preference for moderately sized a2 residues in GGTase-I substrates, peptide substrate structure-activity relationship, overview. Identification of specific active-site residues within rat GGTase-I involved in substrate recognition
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?
additional information
?
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the enzyme modifies proteins by attaching a 20-carbon isoprenoid group to a cysteine residue near the C-terminus of a target protein. The enzyme requires a C-terminal Ca1a2X sequence on its substrates, with the a1, a2, and X residues serving as substrate-recognition elements for GGTase-I. Crystallographic structures of rat GGTase-I show a tightly packed and hydrophobic a2 residue binding pocket, consistent with a preference for moderately sized a2 residues in GGTase-I substrates, peptide substrate structure-activity relationship, overview. Identification of specific active-site residues within rat GGTase-I involved in substrate recognition
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?
additional information
?
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GGTase-I can transfer isoprenoids to intracellular proteins that contain CAAX motifs. The isoprenoid groups can be selectively recognized by GGTase-I. The 20-carbon isoprenoid geranylgeranyl from its donor geranylgeranyl diphosphate (GGPP) is specific to GGTase-I. Residues Lysalpha164, Hisbeta219, Argbeta263, Lysbeta266 and Tyrbeta272 in GGTase-I can form hydrogen bonds with GGPP. No activity with H-Ras
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?
additional information
?
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GGTase-I can transfer isoprenoids to intracellular proteins that contain CAAX motifs. The isoprenoid groups can be selectively recognized by GGTase-I. The 20-carbon isoprenoid geranylgeranyl from its donor geranylgeranyl diphosphate (GGPP) is specific to GGTase-I. Residues Lysalpha164, Hisbeta219, Argbeta263, Lysbeta266 and Tyrbeta272 in GGTase-I can form hydrogen bonds with GGPP. No activity with H-Ras
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?
additional information
?
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enzyme prefers farnesyl diphosphate over geranylgeranyl diphosphate, but catalyzes the reactions of both substrates, i.e. reactions of EC 2.5.1.58 and EC 2.5.1.59, respectively
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additional information
?
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requires geranylgeranylation of rho1p for the correct function of enzyme
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?
additional information
?
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most of the CaaX-containing proteins with X= Leu and X= Met are good substrates of PGGT-I, whereas those with X= Phe are poor substrates for PGGT-I, Trypanosma cruzi j2 DNAJ protein, Trypanosoma cruzi PRL-1 protein tyrosine phosphatase, CHFM (a small GTPase like protein), and Trypanosoma cruzi Rho1 GTPase are no substrates for PGGT-I
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?
additional information
?
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most of the CaaX-containing proteins with X= Leu and X= Met are good substrates of PGGT-I, whereas those with X= Phe are poor substrates for PGGT-I, Trypanosma cruzi j2 DNAJ protein, Trypanosoma cruzi PRL-1 protein tyrosine phosphatase, CHFM (a small GTPase like protein), and Trypanosoma cruzi Rho1 GTPase are no substrates for PGGT-I
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?
