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2.6.1.85: aminodeoxychorismate synthase

This is an abbreviated version!
For detailed information about aminodeoxychorismate synthase, go to the full flat file.

Word Map on EC 2.6.1.85

Reaction

chorismate
+
L-glutamine
=
4-amino-4-deoxychorismate
 +
L-glutamate

Synonyms

4-amino-4-deoxychorismate synthase, ADC, ADC synthase, ADCS, aminodeoxychorismate synthase, chorismate:L-glutamine amido-ligase, EC 6.3.5.8, PabA, PabAB, PabB, PhzE, PvADCS

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.85 aminodeoxychorismate synthase

Inhibitors

Inhibitors on EC 2.6.1.85 - aminodeoxychorismate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(5R,6R)-4-ammonio-5-((1-carboxylatovinyl)oxy)-6-hydroxycyclohex-1-ene-1-carboxylate
-
transition-state analogue, competitive
1-hydroxyphenazine
inhibitory above 0.200 mM
2-fluorochorismate
-
irreversible, covalent modification of K274
atrop-abyssomicin C
-
NH3
-
inhibitor of the glutamine amidotransferase reaction (Ki = 5 mM, lowered to 0.27 mM if considered that NH3 and not NH4+ is the true inhibitor (pKa value of 9.24))
phosphate
phosphate buffer competitively inhibits PhzE, about 20% inhibition with 100 mM potassium phosphate at pH 7.0
pyocyanin
inhibitory above 0.250 mM
additional information
-