2.7.1.190: aminoglycoside 2''-phosphotransferase
This is an abbreviated version!
For detailed information about aminoglycoside 2''-phosphotransferase, go to the full flat file.
Word Map on EC 2.7.1.190
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2.7.1.190
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aph3\'-iiia
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kanamycin
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enterococci
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aac6\'-ie-aph2\'\'-ia
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faecium
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aminoglycoside-modifying
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phosphotransferases
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aph2\'\'-ic
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amikacin
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gentamicin-resistant
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aac6\'-aph2
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tobramycin
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4,6-disubstituted
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casseliflavus
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aac6'-ie
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ant6\'-ia
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gallinarum
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aminoglycoside-resistance
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lividomycin
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butirosin
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o-phosphorylation
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sisomicin
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durans
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molecular biology
- 2.7.1.190
-
aph3\'-iiia
- kanamycin
-
enterococci
-
aac6\'-ie-aph2\'\'-ia
- faecium
-
aminoglycoside-modifying
-
phosphotransferases
-
aph2\'\'-ic
- amikacin
-
gentamicin-resistant
-
aac6\'-aph2
- tobramycin
-
4,6-disubstituted
- casseliflavus
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aac6'-ie
-
ant6\'-ia
- gallinarum
-
aminoglycoside-resistance
- lividomycin
- butirosin
-
o-phosphorylation
- sisomicin
- durans
- molecular biology
Reaction
Synonyms
AAC(6')-APH(2''), AAC(6')-Ie/APH(2'')-Ia, aac6-aph2, aacA-aphD, AME, aminoglycoside (2'') kinase, aminoglycoside 2''-phosphotransferase IVa, aminoglycoside 2''-phosphotransferase type IIIa, aminoglycoside kinase, aminoglycoside phosphotransferase, aminoglycoside-2''-phosphotransferase, aminoglycoside-2''-phosphotransferase type IVa, aminoglycoside-modification enzyme, APH, APH(2''), APH(2'')-Ia, APH(2'')-Ia aminoglycoside resistance enzyme, APH(2'')-Id, Aph(2'')-If, APH(2'')-IIIa, APH(2'')-IVa, aphD, AphSR2, bifunctional 6'-aminoglycoside acetyltransferase/2"-aminoglycoside phosphotransferase, bifunctional AAC/APH, bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia, bifunctional aminoglycoside acetyltransferase/phosphotransferase, gentamicin kinase, gentamicin phosphotransferase, gentamicin resistance protein
ECTree
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Reference on EC 2.7.1.190 - aminoglycoside 2''-phosphotransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Toth, M.; Frase, H.; Antunes, N.T.; Vakulenko, S.B.
Novel aminoglycoside 2-phosphotransferase identified in a gram-negative pathogen
Antimicrob. Agents Chemother.
57
452-457
2013
Campylobacter jejuni (Q4VR94), Campylobacter jejuni
Shi, K.; Houston, D.R.; Berghuis, A.M.
Crystal structures of antibiotic-bound complexes of aminoglycoside 2-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinases
Biochemistry
50
6237-6244
2011
Enterococcus casseliflavus (O68183)
Ferretti, J.; Gilmore, K.; Courvalin, P.
Nucleotide sequence analysis of the gene specifying the bifunctional 6-aminoglycoside acetyltransferase 2-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities
J. Bacteriol.
167
631-638
1986
Enterococcus faecalis (P0A0C2), Enterococcus faecalis ATCC 700802 (P0A0C2)
Badarau, A.; Shi, Q.; Chow, J.W.; Zajicek, J.; Mobashery, S.; Vakulenko, S.
Aminoglycoside 2''-phosphotransferase type IIIa from Enterococcus
J. Biol. Chem.
283
7638-7647
2008
Enterococcus sp.
Smith, C.A.; Toth, M.; Frase, H.; Byrnes, L.J.; Vakulenko, S.B.
Aminoglycoside 2-phosphotransferase IIIa (APH(2)-IIIa) prefers GTP over ATP: structural templates for nucleotide recognition in the bacterial aminoglycoside-2 kinases
J. Biol. Chem.
287
12893-12903
2012
Enterococcus gallinarum (P96762)
Shi, K.; Berghuis, A.M.
Structural basis for dual nucleotide selectivity of aminoglycoside 2-phosphotransferase IVa provides insight on determinants of nucleotide specificity of aminoglycoside kinases
J. Biol. Chem.
287
13094-13102
2012
Enterococcus casseliflavus (O68183)
Frase, H.; Toth, M.; Vakulenko, S.
Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia enzyme
J. Biol. Chem.
287
43262-43269
2012
Staphylococcus aureus (P0A0C1)
Tabatabaei, I.; Ruf, S.; Bock, R.
A bifunctional aminoglycoside acetyltransferase/phosphotransferase conferring tobramycin resistance provides an efficient selectable marker for plastid transformation
Plant Mol. Biol.
93
269-281
2017
Staphylococcus aureus (P0A0C1)
Smith, C.; Toth, M.; Stewart, N.; Maltz, L.; Vakulenko, S.
Structural basis for the diversity of the mechanism of nucleotide hydrolysis by the aminoglycoside-2''-phosphotransferases
Acta Crystallogr. Sect. D
75
1129-1137
2019
Enterococcus sp.
Caldwell, S.J.; Berghuis, A.M.
Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2'')-Ia
Antimicrob. Agents Chemother.
62
e00202-18
2018
Enterococcus casseliflavus
Kaplan, E.; Guichou, J.F.; Chaloin, L.; Kunzelmann, S.; Leban, N.; Serpersu, E.H.; Lionne, C.
Aminoglycoside binding and catalysis specificity of aminoglycoside 2''-phosphotransferase IVa A thermodynamic, structural and kinetic study
Biochim. Biophys. Acta
1860
802-813
2016
Enterococcus casseliflavus
Leban, N.; Kaplan, E.; Chaloin, L.; Godreuil, S.; Lionne, C.
Kinetic characterization and molecular docking of novel allosteric inhibitors of aminoglycoside phosphotransferases
Biochim. Biophys. Acta
1861
3464-3473
2017
Enterococcus casseliflavus
Zhu, L.; Liu, R.; Liu, T.; Zou, X.; Xu, Z.; Guan, H.
A novel strategy to screen inhibitors of multiple aminoglycoside-modifying enzymes with ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry
J. Pharm. Biomed. Anal.
164
520-527
2019
Staphylococcus aureus (P0A0C1)
Rudakova, N.; Alekseeva, M.; Zakharevich, N.; Mavletova, D.; Danilenko, V.
Aminoglycoside phosphotransferase AphSR2 from Streptomyces rimosus ATCC 10970 dependence of antibiotic Resistance on serine-threonine protein kinases PkSR1 and PkSR2
Russ. J. Genet.
56
112-117
2020
Streptomyces rimosus, Streptomyces rimosus ATCC 10970
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