2.7.1.86: NADH kinase
This is an abbreviated version!
For detailed information about NADH kinase, go to the full flat file.
Word Map on EC 2.7.1.86
Reaction
Synonyms
ATP-NADH kinase, ATP:NADH 2'-phosphotransferase, ATP:NADH2 2'-phosphotransferase, diphosphopyridine nucleotide (reduced) kinase, DPNH kinase, EC 2.7.1.96, kinase, reduced nicotinamide adenine dinucleotide (phosphorylating), Mfnk, NAD(H) kinase, NAD(H)K, NADH kinase, NADH kinase POS5, mitochondrial, NADH2 kinase, NADHK, NADK, NADK-1, NADK1, NADK3, nicotinamide adenine dinucleotide (reduced) kinase, nicotinamide adenine dinucleotide hydride kinase, Pos5, Pos5p, Posp5, Ppnk, reduced diphosphopyridine nucleotide kinase, reduced nicotinamide adenine dinucleotide kinase (phosphorylating), Utr1, YEF1, YEL041W
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2.7.1.86 NADH kinaseAdvanced search results
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Substrates Products on EC 2.7.1.86 - NADH kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + NAD+
ADP + NADP+
-
phenotypic effects during overexpression analyzed by simulation of major metabolic fluxes
-
-
?
ATP + NAD+
ADP + NADP+
Aspergillus nidulans CBS 513.88 / FGSC A1513
-
phenotypic effects during overexpression analyzed by simulation of major metabolic fluxes
-
-
?
ATP + NAD+
ADP + NADP+
-
2fold preference for NADH over NAD+
-
?
ATP + NAD+
ADP + NADP+
-
activity with NAD+ is 50fold lower than with NADH
-
-
?
ATP + NAD+
ADP + NADP+
the enzyme has much higher NADH kinase than NAD kinase activity
-
-
?
ATP + NADH
ADP + NADPH
-
preferentially phosphorylates reduced NAD+ but can use oxidized NAD+. ATP is preferred phophoryl donor but UTP, GTP, and CTP may substitute with lower activity
-
-
?
ATP + NADH
ADP + NADPH
shows a 2fold preference for NADH over NAD+
-
-
?
ATP + NADH
ADP + NADPH
-
isoform NADK1 shows 169% activity compared to NAD+
-
-
?
ATP + NADH
ADP + NADPH
-
prefers NADH as a substrate, but can also use NAD+ with a much lower efficiency
-
-
?
ATP + NADH
ADP + NADPH
-
uses NADH as the preferred diphosphonicotinamide nucleotide donor
-
-
?
ATP + NADH
ADP + NADPH
-
uses NADH as the preferred diphosphonicotinamide nucleotide donor
-
-
?
ATP + NADH
ADP + NADPH
-
2fold preference for NADH over NAD+
-
?
ATP + NADH
ADP + NADPH
-
may be involved in maintaining the level of triphosphopyridine nucleotide in the mitochondria
-
?
ATP + NADH
ADP + NADPH
-
the enzyme has primarily NADH kinase activity in mitochondria, mitochondrial NADPH is largely provided by the POS5 NADH kinase
-
?
ATP + NADH
ADP + NADPH
phosphorylates NADH with 2% of the specific activity of its NAD kinase activity
-
-
?
ATP + NADH
ADP + NADPH
possesses 33% activity with NADH and ATP compared to the activity obtained with NAD and ATP
-
-
?
ATP + NADH
ADP + NADPH
Pos5 is responsible for all mitochondrial NAD/NADH kinase. Transitory exposure of Pos5 to the cytoplasm is required for the viability of utr1 mutants
-
-
?
ATP + NADH
ADP + NADPH
isoform Pos5p shows 167% activity compared to NAD+
-
-
?
ATP + NADH
ADP + NADPH
the enzyme has much higher NADH kinase than NAD kinase activity
-
-
?
ATP + NADH
ADP + NADPH
-
NAD+ completely ineffective
-
?
ATP + NADH
ADP + NADPH
the cytoplasmic NADH kinase is a primary source of the cytosolic NADPH
-
-
?
ATP + NADH
ADP + NADPH
the cytoplasmic NADH kinase is a primary source of the cytosolic NADPH
-
-
?
tetrapolyphosphate + NADH
tripolyphosphate + NADPH
-
-
-
-
?
additional information
?
-
-
diphosphate or polyphosphate is not used as a phosphoryl donor
-
-
?
additional information
?
-
-
no substrate: diphosphate, polyphosphate
-
-
?
additional information
?
-
-
the purified enzyme presents almost no activity against NAD+
-
-
?
additional information
?
-
-
the purified enzyme presents almost no activity against NAD+
-
-
?
additional information
?
-
-
POS5 NADH kinase is required for mitochondrial stability with a critical role in detoxification of reactive oxygen species
-
-
?
additional information
?
-
-
NADH kinase does not increase the rate of xylose consumption
-
-
?
additional information
?
-
NADH kinase does not increase the rate of xylose consumption
-
-
?
additional information
?
-
NADH kinase does not increase the rate of xylose consumption
-
-
?
additional information
?
-
does not accept poly(P) as phosphoryl donor
-
-
?
additional information
?
-
enzyme additionally show NAD+ kinase activity, Km value for NAD+ is 0.5 mM
-
-
?
additional information
?
-
-
enzyme additionally show NAD+ kinase activity, Km value for NAD+ is 0.5 mM
-
-
?
