2.7.4.9: dTMP kinase
This is an abbreviated version!
For detailed information about dTMP kinase, go to the full flat file.
Reaction
Synonyms
ATP: TMP phosphotransferase, Cdc8, deoxythymidine 5'-monophosphate kinase, deoxythymidine monophosphate kinase, dTMP kinase, dTMP kinases, dTMPK, human thymidine monophosphate kinase (hTMPK), kinase, thymidine monophosphate (phosphorylating), kinase, thymidylate (phosphorylating), ORF454, PfTMK, S. aureus thymidylate kinase, thymidine 5'-monophosphate kinase, thymidine kinase, thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, TK1, TMK, TMP kinase, TMPK, TMPKmt, TTHA1607, TYMK
ECTree
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General Information
General Information on EC 2.7.4.9 - dTMP kinase
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drug target
evolution
malfunction
Zea mays has a single TK1 (ZmTK1) gene and mutant plants are albino and display reduced genome copy number in chloroplasts
physiological function
molecular dynamics simulation and inhibitory studies show that the enzyme has structural features which suggest using it as a target to develop new anti-plasmodial drugs
drug target
the enzyme is a potential drug target for antifungal drug discovery for a number of reasons. First, it shows several structural differences compared to its human counterpart. These include the Ca-loop, as well as significant shifts in the location of helices and strands. The structural differences can form potential binding sites for allosteric inhibitors. Second, the fact the CaTMPK can utilize dGMP as a substrate suggests that competitive inhibitors that resemble purine nucleosides may preferentially bind to CaTMPK versus the human enzyme
drug target
the enzyme is indispensable for bacterial DNA biosynthesis and has been pursued for the development of new antibacterial agents including against Mycobacterium tuberculosis
drug target
thymidylate kinase is a key enzyme for the synthesis of DNA, making it an important target for the development of anticancer, antibacterial and antiparasitic drugs
drug target
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the enzyme is a potential drug target for antifungal drug discovery for a number of reasons. First, it shows several structural differences compared to its human counterpart. These include the Ca-loop, as well as significant shifts in the location of helices and strands. The structural differences can form potential binding sites for allosteric inhibitors. Second, the fact the CaTMPK can utilize dGMP as a substrate suggests that competitive inhibitors that resemble purine nucleosides may preferentially bind to CaTMPK versus the human enzyme
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drug target
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thymidylate kinase is a key enzyme for the synthesis of DNA, making it an important target for the development of anticancer, antibacterial and antiparasitic drugs
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drug target
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the enzyme is indispensable for bacterial DNA biosynthesis and has been pursued for the development of new antibacterial agents including against Mycobacterium tuberculosis
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study on influence of sequence evolution and conformational dynamics on its quaternary structure and function. Based on extensive sequence and structure analyses, the study detects several non-conserved residues which are linked by co-evolution and are implicated in the observed variations in flexibility, oligomeric assembly and substrate specificity among the homologs. These lead to differences in the pattern of interactions at the active site in thymidylate kinases of different specificity
evolution
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study on influence of sequence evolution and conformational dynamics on its quaternary structure and function. Based on extensive sequence and structure analyses, the study detects several non-conserved residues which are linked by co-evolution and are implicated in the observed variations in flexibility, oligomeric assembly and substrate specificity among the homologs. These lead to differences in the pattern of interactions at the active site in thymidylate kinases of different specificity
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the enzyme is critical for the synthesis of the thymidine triphosphate precursor necessary for DNA synthesis
physiological function
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thymidylate kinase is a key enzyme in the control of nucleotide metabolism and synthesis of DNA
physiological function
critical enzyme in the de novo biosynthesis pathway of pyrimidine nucleotides
physiological function
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essential enzyme for the growth of the organism because of its critical role in the de novo synthesis of deoxythymidine 5'-diphosphate (TDP), a precursor for TTP that is required for DNA replication and repair
physiological function
key enzyme that plays an important role in DNA synthesis
physiological function
the enzyme is indispensable for bacterial DNA biosynthesis
physiological function
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key enzyme that plays an important role in DNA synthesis
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physiological function
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the enzyme is indispensable for bacterial DNA biosynthesis
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physiological function
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critical enzyme in the de novo biosynthesis pathway of pyrimidine nucleotides
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