2.7.7.19: polynucleotide adenylyltransferase
This is an abbreviated version!
For detailed information about polynucleotide adenylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.19
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2.7.7.19
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polyadenylation
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polymerases
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pre-mrnas
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phosphorylase
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exosome
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rna-binding
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vaccinia
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trna
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oligoa
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helicase
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tramp
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aauaaa
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deadenylation
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polya-binding
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pnpase
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dna-dependent
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meiotic
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noncanonical
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exonuclease
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3'-terminal
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cordycepin
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oligoadenylation
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exoribonucleases
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polyu
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drug development
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endoribonuclease
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medicine
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snornas
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non-templated
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cca-adding
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hfq
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polya-specific
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deadenylase
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biotechnology
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polya-tailed
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snrnp
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pabpn1
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degradosome
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exonucleolytic
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3'-deoxyadenosine
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pancreatitis-associated
- 2.7.7.19
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polyadenylation
- polymerases
- pre-mrnas
- phosphorylase
-
exosome
-
rna-binding
- vaccinia
- trna
-
oligoa
- helicase
-
tramp
-
aauaaa
-
deadenylation
-
polya-binding
- pnpase
-
dna-dependent
-
meiotic
-
noncanonical
-
exonuclease
-
3'-terminal
- cordycepin
-
oligoadenylation
- exoribonucleases
- polyu
- drug development
-
endoribonuclease
- medicine
- snornas
-
non-templated
-
cca-adding
- hfq
-
polya-specific
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deadenylase
- biotechnology
-
polya-tailed
-
snrnp
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pabpn1
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degradosome
-
exonucleolytic
- 3'-deoxyadenosine
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pancreatitis-associated
Reaction
Synonyms
AAS, adenosine triphosphate:ribonucleic acid adenylyltransferase, AMP polynucleotidylexotransferase, ATP-polynucleotide adenylyltransferase, ATP:polynucleotidylexotransferase, CC-adding enzyme, Cid1, Cid14, FAM46A, FAM46B, FAM46C, FAM46D, germline development 2, GLD-2, GLD2, GLD4, Hs2, MTPAP, neo-PAP, non-canonical poly(A) RNA polymerase PAPD7, NTP polymerase, nuclear poly(A) polymerase 1, nuclear speckle targeted PIPKIalpha regulated-poly(A) polymerase, nucleotidyltransferase, polyadenylate, PAP, PAP I, Pap II, PAP1, Pap1p, PAPalpha, PAPbeta, PapD1, PapD5, PAPD7, PAPgamma, PAPOLA, PAPOLB/TPAP, PAPOLG, PAPS1, PAPS2, PAPS4, PcnB, pcnB2, pcnB2 aq_2158, poly A polymerase, poly(A) hydrolase, poly(A) polymerase, poly(A) polymerase gamma, poly(A) polymerase I, poly(A) polymerase II, poly(A) RNA polymerase protein 1, poly(A) synthetase, poly(A)-polymerase, poly(A)polymerase I, polyA polymerase, polyadenylate nucleotidyltransferase, polyadenylate polymerase, polyadenylate synthetase, polyadenylic acid polymerase, polyadenylic polymerase, poly[A] polymerase beta, RNA adenylating enzyme, RNA formation factors, PF1, RNA poly(A) polymerase, Star-PAP, Tb927.3.3160, Tb927.7.3780, terminal riboadenylate transferase, Tpap, Trf5, Trf5p, TUT1, TUTase1, VP55, Wisp, yPAP, ZCCHC6
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2.7.7.19 polynucleotide adenylyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.7.7.19 - polynucleotide adenylyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + miR-21-5p
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enzyme isoform PAPD5 adenylates the 3'-end of miR-21-5p, marking it for 3'-to-5'-trimming by the poly(A) specific ribonuclease PARN
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?
ATP + RNA
?
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processing and activation of stored mRNAs after resumption of development
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?
ATP + RNA
?
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the enzymatic machinery that catalyzes formation of 3'-ends of polyadenylated mRNAs consists of two distinct factors: a poly(A) polymerase and a cleavage/specificity factor required for the correct cleavage at the poly(A) site of pre-mRNA
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-
?
ATP + RNA
?
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synthetic and hydrolytic activities are functions of the same molecule, the level of adenine nucleotides regulates synthesis and degradation of poly(A), the hydrolytic reaction is responsible for poly(A) shortening or turnover, poly(A) itself is a storage form of adenine nucleotides
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?
ATP + RNA
?
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2 enzymes participate in the polyadenylation of chromosomal RNA, by a coupled mechanism, the chromatin bound enzyme adds 120-130 adenosine nucleotides to chromosomal RNA, the nucleoplasmic enzyme completes the polyadenylation by adding 80-90 more AMP units to the polyadenylated end
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?
additional information
?
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enzyme isoform GLD-2 enhances entry into the meiotic cell cycle at least in part by activating oisoform GLD-1 expression
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?
additional information
?
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rRNA fragments and tRNA precursors originating from the internal spacer regions of the rrn operons, in particular, rrnB are abundant poly(A) polymerase targets. Glu tRNA precursors originating from the rrnB and rrnG transcripts exhibit long 3' trailers that are primarily removed by polyribonucleotide nucleotidyltransferase and to a lesser extent by RNase II and poly(A) polymerase. Glu tRNA precursors still harbouring the 5' leader can be degraded by a 3' to 5' quality control pathway involving poly(A) polymerase
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?
additional information
?
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the enzyme is responsible for the synthesis of the poly(A) tail at the 3'-end of eukaryotic mRNA
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?
additional information
?
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enzyme may act in the ooplasm on the progression of metaphase I to metaphase II during oocyte maturation
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?
