Reference on EC 2.3.1.7 - carnitine O-acetyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Farrell, S.O.; Fiol, C.J.; Reddy, J.K.; Bieber, L.L.
Properties of purified carnitine acyltransferases of mouse liver peroxisomes
J. Biol. Chem.
259
13089-13095
1984
Bos taurus, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley, Torulopsis bovina
Chase, J.F.A.; Pearson, D.J.; Tubbs, P.K.
The preparation of crystalline carnitine acetyltransferase
Biochim. Biophys. Acta
96
162-165
1965
Columba sp., Ovis aries, Sus scrofa
Fritz, I.B.; Schultz, S.K.
Carnitine acetyltransferase. II. Inhibition by carnitine analogues and by sulfhydryl reagents
J. Biol. Chem.
240
2188-2192
1965
Sus scrofa
White, H.L.; Wu, J.C.
Choline and carnitine acetyltransferases of heart
Biochemistry
12
841-846
1973
Columba sp., Oryctolagus cuniculus, Homo sapiens
Edwards, Y.H.; Chase, J.F.A.; Edwards, M.R.; Tubbs, P.K.
Carnitine acetyltransferase: the question of multiple forms
Eur. J. Biochem.
46
209-215
1974
Bos taurus, Cavia porcellus, Columba sp., Ovis aries
Christiansen, R.Z.; Bremer, J.
Acetylation of tris(hydroxymethyl)aminomethane (Tris) and Tris derivatives by carnitine acetyltransferase
FEBS Lett.
86
99-102
1978
Columba sp.
Kawamoto, S.; Ueda, M.; Nozaki, C.; Yamamura, M.; Tanaka, A.; Fukui, S.
Localization of carnitine acetyltransferase in peroxisomes and in mitochondria of n-alkane-grown Candida tropicalis
FEBS Lett.
96
37-40
1978
Candida tropicalis
Mittal, B.; Kurup, C.K.R.
Purification of clofibrate-induced carnitine acetyltransferase from rat liver mitochondria
Biochim. Biophys. Acta
619
90-97
1980
Columba sp., Rattus norvegicus, Sus scrofa
Bieber, L.L.; Markwell, M.A.K.
Peroxisomal and microsomal carnitine acetyltransferases
Methods Enzymol.
71
351-358
1981
Bos taurus, Cavia porcellus, Columba sp., Rattus norvegicus, Sus scrofa
-
Claus, R.; Kaeppeli, O.; Fiechter, A.
Purification of carnitine acetyltransferase from Candida tropicalis
Anal. Biochem.
127
376-379
1982
Candida tropicalis, Columba sp.
Ueda, M.; Tanaka, A.; Fukui, S.
Peroxisomal and mitochondrial carnitine acetyltransferases in alkane-grown yeast Candida tropicalis
Eur. J. Biochem.
124
205-210
1982
Candida tropicalis, Columba sp., Rattus norvegicus, Sus scrofa
Huckle, W.R.; Tamblyn, T.M.
Purification and properties of carnitine acetyltransferases from bovine spermatozoa and heart
Arch. Biochem. Biophys.
226
94-110
1983
Bos taurus, Columba sp., Ovis aries, Rattus norvegicus
Miyazawa, S.; Ozasa, H.; Furuta, S.; Osumi, T.; Hashimoto, T.
Purification and properties of carnitine acetyltransferase from rat liver
J. Biochem.
93
439-451
1983
Columba sp., Rattus norvegicus
Ueda, M.; Tanaka, A.; Fukui, S.
Characterization of peroxisomal and mitochondrial carnitine acetyltransferases purified from alkane-grown Candida tropicalis
Eur. J. Biochem.
138
445-449
1984
Candida tropicalis, Columba sp., Rattus norvegicus
Ueda, M.; Tanaka, A.; Horikawa, S.; Numa, S.; Fukui, S.
Synthesis in vitro of precursor-type carnitine acetyltransferase with messenger RNA from Candida tropicalis
Eur. J. Biochem.
138
451-457
1984
Candida tropicalis
Zhong, J.; Fong, J.C.; Schulz, H.
Inhibition of carnitine acetyltransferase by metabolites of 4-pentenoic acid
Arch. Biochem. Biophys.
240
524-529
1985
Columba sp.
Bieber, L.L.; Fiol, C.
Purification and assay of carnitine acyltransferases
Methods Enzymol.
123
276-284
1986
Candida tropicalis, Mus musculus
Gandour, R.D.; Colucci, W.J.; Stelly, T.C.; Brady, P.S.; Brady, L.J.
Active-site probes of carnitineacyltransferases. Inhibition of carnitine acetyltransferase by hemiacetylcarnitinium, a reaction intermediate analogue
Biochem. Biophys. Res. Commun.
138
735-741
1986
Columba sp., Rattus norvegicus
Kozulic, B.; Kppeli, O.; Meussdoerffer, F.; Fiechter, A.
Characterization of a soluble carnitine acetyltransferase from Candida tropicalis
Eur. J. Biochem.
168
245-250
1987
Candida tropicalis
Bloisi, W.; Colombo, I.; Garavaglia, B.; Giardini, R.; Finocchiaro, G.; Didonato, S.
Purification and properties of carnitine acetyltransferase from human liver
Eur. J. Biochem.
189
539-546
1990
Homo sapiens, Rattus norvegicus, Sus scrofa
Chung, C.; Chung, C.D.; Bieber, L.L.
Purification of heart and liver mitochondrial carnitine acetyltransferase
Protein Expr. Purif.
2
426-431
1991
Rattus norvegicus
Kispal, G.; Cseko, J.; Alkonyi, I.; Sandor, A.
Isolation and characterization of carnitine acetyltransferase from S. cerevisiae
Biochim. Biophys. Acta
1085
217-222
1991
Bos taurus, Saccharomyces cerevisiae, Candida tropicalis, Columba sp., Homo sapiens, Rattus norvegicus, Torulopsis bovina
Saeed, A.; McMillin, J.B.; Wolkowicz, P.E.; Brouillette, W.J.
Carnitine acyltransferase enzymic catalysis requires a positive charge on the carnitine cofactor
Arch. Biochem. Biophys.
305
307-312
1993
Columba sp.
Lu, F.J.; Huang, T.S.; Chen, Y.S.
Effects of humic acid-metal complexes on hepatic carnitine palmitoyltransferase, carnitine acetyltransferase and catalase activities
Environ. Toxicol. Chem.
13
435-441
1994
Mus musculus, Mus musculus BALB/c
-
Alhomida, A.S.
Inhibition studies of the carnitine acetyltransferase from skeletal muscle of the camel (Camelus dromedarius) by sulfhydryl reagents and metal ions
Biochem. Mol. Biol. Int.
39
923-931
1996
Camelus dromedarius, Columba sp., Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae
Alhomida, A.S.; Al-Jafari, A.A.; Duhaiman, A.S.; Rabbani, N.; Junaid, M.A.
Kinetic properties of purified carnitine acetyltransferase from the skeletal muscle of Arabian camel (Camelus dromedarius)
Biochimie
78
204-208
1996
Camelus dromedarius, Columba sp., Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Alhomida, A.S.; Duhaiman, A.S.; Al-Jafari, A.A.; Junaid, M.A.
Purification of carnitine acetyltransferase from skeletal muscle of the camel (Camelus dromedarius)
Mol. Cell. Biochem.
165
95-101
1996
Bos taurus, Camelus dromedarius, Columba sp., Homo sapiens, Mus musculus, Rattus norvegicus
Jernejc, K.; Legisa, M.
Purification and properties of carnitine acetyltransferase from citric acid producing Aspergillus niger
Appl. Biochem. Biotechnol.
60
151-158
1996
Aspergillus niger, Bos taurus, Candida tropicalis, Columba sp., Cutaneotrichosporon curvatum, Cyberlindnera jadinii, Homo sapiens, Lipomyces starkeyi, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Sus scrofa
Kawachi, H.; Atomi, H.; Ueda, M.; Hashimoto, N.; Kobayashi, K.; Yoshida, T.; Kamasawa, N.; Osumi, M.; Tanaka, A.
Individual expression of Candida tropicalis peroxisomal and mitochondrial carnitine acetyltransferase-encoding genes and subcellular localization of the products in Saccharomyces cerevisiae
J. Biochem.
120
731-735
1996
Saccharomyces cerevisiae, Candida tropicalis
Kawachi, H.; Atomi, H.; Ueda, M.; Tanaka, A.
Peroxisomal and mitochondrial carnitine acetyltransferases of the n-alkane-assimilating yeast Candida tropicalis. Analysis of gene structure and translation products
Eur. J. Biochem.
238
845-852
1996
Saccharomyces cerevisiae, Candida tropicalis, Columba sp., Homo sapiens
Sheridan, R.; Ratledge, C.
Changes in cell morphology and carnitine acetyltransferase activity in Candida albicans following growth on lipids and serum and after in vivo incubation in mice
Microbiology
142
3171-3180
1996
Candida albicans, Candida tropicalis, Homo sapiens
-
Brunner, S.; Kramar, K.; Denhardt, D.T.; Hofbauer, R.
Cloning and characterization of murine carnitine acetyltransferase: evidence for a requirement during cell cycle progression
Biochem. J.
322
403-410
1997
Saccharomyces cerevisiae, Columba sp., Homo sapiens, Mus musculus, Mus musculus (P47934), Sus scrofa, Mus musculus S3T3(ATCC CCL-92)
-
Abbas, A.S.; Wu, G.; Schulz, H.
Carnitine acetyltransferase is not a cytosolic enzyme in rat heart and therefore cannot function in the energy-linked regulation of cardiac fatty acid oxidation
J. Mol. Cell. Cardiol.
30
1305-1309
1998
Bos taurus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Ramsay, R.R.
The carnitine acyltransferases: modulators of acyl-CoA-dependent reactions
Biochem. Soc. Trans.
28
182-186
2000
Homo sapiens, Rattus norvegicus
Lian, W.; Govindasamy, L.; Gu, Y.; Kukar, T.; Agbandje-McKenna, M.; McKenna, R.; Wu, D.
Crystallization and preliminary X-ray crystallographic studies on recombinant human carnitine acetyltransferase
Acta Crystallogr. Sect. D
58
1193-1194
2002
Columba sp., Homo sapiens
Liu, J.; Killilea, D.W.; Ames, B.N.
Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha -lipoic acid
Proc. Natl. Acad. Sci. USA
99
1876-1881
2002
Columba sp., Oryctolagus cuniculus, Rattus norvegicus
Jogl, G.; Tong, L.
Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport
Cell
112
113-122
2003
Homo sapiens, Mus musculus, Mus musculus (P47934)
Jogl, G.; Hsiao, Y.S.; Tong, L.
Structure and function of carnitine acyltransferases
Ann. N. Y. Acad. Sci.
1033
17-29
2004
Mus musculus
Wu, D.; Govindasamy, L.; Lian, W.; Gu, Y.; Kukar, T.; Agbandje-McKenna, M.; McKenna, R.
Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer
J. Biol. Chem.
278
13159-13165
2003
Homo sapiens
Hsiao, Y.S.; Jogl, G.; Tong, L.
Structural and biochemical studies of the substrate selectivity of carnitine acetyltransferase
J. Biol. Chem.
279
31584-31589
2004
Mus musculus
Cordente, A.G.; Lopez-Vinas, E.; Vazquez, M.I.; Swiegers, J.H.; Pretorius, I.S.; Gomez-Puertas, P.; Hegardt, F.G.; Asins, G.; Serra, D.
Redesign of carnitine acetyltransferase specificity by protein engineering
J. Biol. Chem.
279
33899-33908
2004
Rattus norvegicus (Q704S8)
Govindasamy, L.; Kukar, T.; Lian, W.; Pedersen, B.; Gu, Y.; Agbandje-McKenna, M.; Jin, S.; McKenna, R.; Wu, D.
Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase
J. Struct. Biol.
146
416-424
2004
Homo sapiens (P43155), Homo sapiens
Ramsay, R.R.; Naismith, J.H.
A snapshot of carnitine acetyltransferase
Trends Biochem. Sci.
28
343-346
2003
Homo sapiens, Mus musculus
Cordente, A.G.; Lopez-Vinas, E.; Vazquez, M.I.; Gomez-Puertas, P.; Asins, G.; Serra, D.; Hegardt, F.G.
Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase
Biochemistry
45
6133-6141
2006
Rattus norvegicus
Prieto, J.A.; Andrade, F.; Aldamiz-Echevarria, L.; Sanjurjo, P.
Determination of free and total carnitine in plasma by an enzymatic reaction and spectrophotometric quantitation spectrophotometric determination of carnitine
Clin. Biochem.
39
1022-1027
2006
Columba livia
Cordente, A.G.; Swiegers, J.H.; Hegardt, F.G.; Pretorius, I.S.
Modulating aroma compounds during wine fermentation by manipulating carnitine acetyltransferases in Saccharomyces cerevisiae
FEMS Microbiol. Lett.
267
159-166
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P32796)
Hsiao, Y.S.; Jogl, G.; Tong, L.
Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates
J. Biol. Chem.
281
28480-28487
2006
Mus musculus (P47934), Mus musculus
Westin, M.A.; Hunt, M.C.; Alexson, S.E.
Short- and medium-chain carnitine acyltransferases and acyl-CoA thioesterases in mouse provide complementary systems for transport of beta-oxidation products out of peroxisomes
Cell. Mol. Life Sci.
65
982-990
2008
Mus musculus, Mus musculus 129/Sv
Franken, J.; Kroppenstedt, S.; Swiegers, J.H.; Bauer, F.F.
Carnitine and carnitine acetyltransferases in the yeast Saccharomyces cerevisiae: a role for carnitine in stress protection
Curr. Genet.
53
347-360
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P32796)
Zhou, H.; Lorenz, M.C.
Carnitine acetyltransferases are required for growth on non-fermentable carbon sources but not for pathogenesis in Candida albicans
Microbiology
154
500-509
2008
Candida albicans
Sharma, S.; Sud, N.; Wiseman, D.; Carter, A.; Kumar, S.; Hou, Y.; Rau, T.; Wilham, J.; Harmon, C.; Oishi, P.; Fineman, J.; Black, S.
Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension
Am. J. Physiol. Lung Cell Mol. Physiol.
294
L46-L56
2008
Ovis aries
En-Nosse, M.; Hartmann, S.; Trinkaus, K.; Alt, V.; Stigler, B.; Heiss, C.; Kilian, O.; Schnettler, R.; Lips, K.S.
Expression of non-neuronal cholinergic system in osteoblast-like cells and its involvement in osteogenesis
Cell Tissue Res.
338
203-215
2009
Homo sapiens, Mus musculus (P47934), Mus musculus
Robic, A.; Faraut, T.; Liaubet, L.; Milan, D.
The carnitine acetyltransferase gene (CRAT): a characterization of porcine transcripts with insights into the 5-end variants of mammalian transcripts and their possible sub-cellular localization
Cell. Mol. Biol. Lett.
14
90-99
2009
Sus scrofa (A9JPD4), Sus scrofa
Strijbis, K.; van Roermund, C.W.; Visser, W.F.; Mol, E.C.; van den Burg, J.; MacCallum, D.M.; Odds, F.C.; Paramonova, E.; Krom, B.P.; Distel, B.
Carnitine-dependent transport of acetyl coenzyme A in Candida albicans is essential for growth on nonfermentable carbon sources and contributes to biofilm formation
Eukaryot. Cell
7
610-618
2008
Candida albicans
Jaudzems, K.; Kuka, J.; Gutsaits, A.; Zinovjevs, K.; Kalvinsh, I.; Liepinsh, E.; Liepinsh, E.; Dambrova, M.
Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism
J. Enzyme Inhib. Med. Chem.
24
1269-1275
2009
Columba livia
Hynes, M.J.; Murray, S.L.; Andrianopoulos, A.; Davis, M.A.
Role of carnitine acetyltransferases in acetyl coenzyme A metabolism in Aspergillus nidulans
Eukaryot. Cell
10
547-555
2011
Aspergillus nidulans
Strijbis, K.; van Roermund, C.W.; van den Burg, J.; van den Berg, M.; Hardy, G.P.; Wanders, R.J.; Distel, B.
Contributions of carnitine acetyltransferases to intracellular acetyl unit transport in Candida albicans
J. Biol. Chem.
285
24335-24346
2010
Candida albicans
Bailey, J.A.; Lahiri, D.K.
Chromatographic separation of reaction products from the choline acetyltransferase and carnitine acetyltransferase assay: differential ChAT and CrAT activity in brain extracts from Alzheimers disease versus controls
J. Neurochem.
122
672-680
2012
Homo sapiens, Rattus norvegicus
Violante, S.; Ijlst, L.; Ruiter, J.; Koster, J.; van Lenthe, H.; Duran, M.; de Almeida, I.T.; Wanders, R.J.; Houten, S.M.; Ventura, F.V.
Substrate specificity of human carnitine acetyltransferase: Implications for fatty acid and branched-chain amino acid metabolism
Biochim. Biophys. Acta
1832
773-779
2013
Homo sapiens
Kienesberger, K.; Pordes, A.G.; Voelk, T.G.; Hofbauer, R.
L-carnitine and PPARalpha-agonist fenofibrate are involved in the regulation of carnitine acetyltransferase (CrAT) mRNA levels in murine liver cells
BMC Genomics
15
514
2014
Mus musculus
Seiler, S.E.; Koves, T.R.; Gooding, J.R.; Wong, K.E.; Stevens, R.D.; Ilkayeva, O.R.; Wittmann, A.H.; DeBalsi, K.L.; Davies, M.N.; Lindeboom, L.; Schrauwen, P.; Schrauwen-Hinderling, V.B.; Muoio, D.M.
Carnitine acetyltransferase mitigates metabolic inertia and muscle fatigue during exercise
Cell Metab.
22
65-76
2015
Homo sapiens
Davies, M.N.; Kjalarsdottir, L.; Thompson, J.W.; Dubois, L.G.; Stevens, R.D.; Ilkayeva, O.R.; Brosnan, M.J.; Rolph, T.P.; Grimsrud, P.A.; Muoio, D.M.
The acetyl group buffering action of carnitine acetyltransferase offsets macronutrient-induced lysine acetylation of mitochondrial proteins
Cell Rep.
14
243-254
2016
Mus musculus
Sharma, S.; Sun, X.; Agarwal, S.; Rafikov, R.; Dasarathy, S.; Kumar, S.; Black, S.
Role of carnitine acetyl transferase in regulation of nitric oxide signaling in pulmonary arterial endothelial cells
Int. J. Mol. Sci.
14
255-272
2013
Homo sapiens
Miyata, Y.; Shimomura, I.
Metabolic flexibility and carnitine flux: The role of carnitine acyltransferase in glucose homeostasis
J. Diabetes Investig.
4
247-249
2013
Mus musculus
Seiler, S.E.; Martin, O.J.; Noland, R.C.; Slentz, D.H.; DeBalsi, K.L.; Ilkayeva, O.R.; An, J.; Newgard, C.B.; Koves, T.R.; Muoio, D.M.
Obesity and lipid stress inhibit carnitine acetyltransferase activity
J. Lipid Res.
55
635-644
2014
Cavia porcellus, Rattus norvegicus
Berg, S.M.; Beck-Nielsen, H.; Faergeman, N.J.; Gaster, M.
Carnitine acetyltransferase A new player in skeletal muscle insulin resistance?
Biochem. Biophys. Rep.
9
47-50
2017
Homo sapiens (P43155), Homo sapiens
Altamimi, T.R.; Thomas, P.D.; Darwesh, A.M.; Fillmore, N.; Mahmoud, M.U.; Zhang, L.; Gupta, A.; Al Batran, R.; Seubert, J.M.; Lopaschuk, G.D.
Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-CoA a possible mechanism for regulation of cardiac energy metabolism
Biochem. J.
475
959-976
2018
Mus musculus (P47934), Mus musculus
Reichenbach, A.; Stark, R.; Mequinion, M.; Denis, R.R.G.; Goularte, J.F.; Clarke, R.E.; Lockie, S.H.; Lemus, M.B.; Kowalski, G.M.; Bruce, C.R.; Huang, C.; Schittenhelm, R.B.; Mynatt, R.L.; Oldfield, B.J.; Watt, M.J.; Luquet, S.; Andrews, Z.B.
AgRP neurons require carnitine acetyltransferase to regulate metabolic flexibility and peripheral nutrient partitioning
Cell Rep.
22
1745-1759
2018
Mus musculus (P47934)
html completed
