Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Jacobson, J.W.; Hart, B.A.; Doy, C.H.; Giles, N.H.
Purification and stability of the multienzyme complex encoded in the arom gene cluster of Neurospora crassa
Biochim. Biophys. Acta
289
1-12
1972
Neurospora crassa
brenda
Polley, L.D.
Purification and characterization of 3-dehydroquinate hydrolase and shikmate oxidoreductase. Evidence for a bifunctional enzyme
Biochim. Biophys. Acta
526
259-266
1978
Physcomitrium patens
brenda
Chaudhuri, S.; Coggins, J.R.
The purification of shikimate dehydrogenase from Escherichia coli
Biochem. J.
226
217-223
1985
Escherichia coli
brenda
Lourenco, E.J.; Neves, V.A.
Partial purification and some properties of shikimate dehydrogenase from tomatoes
Phytochemistry
23
497-499
1984
Solanum lycopersicum
-
brenda
Koshiba, T.
Purification of two forms of the associated 3-dehydroquinate hydro-lyase and shikimate:NADP+ oxidoreductase in Phaseolus mungo seedlings
Biochim. Biophys. Acta
522
10-18
1978
Vigna mungo
brenda
Sanderson, G.W.
5-Dehydroshikimate reductase in the tea plant (Camellia sinensis L.). Properties and distribution
Biochem. J.
98
248-252
1966
Camellia sinensis
brenda
Higuchi, T.; Shimada, M.
Changes in activity of shikimate:NADP oxidoreductase in relation to lignification of bamboo
Plant Cell Physiol.
8
61-69
1967
Bambusa sp.
-
brenda
Balinsky, D.; Davies, D.D.
Aromatic biosynthesis in higher plants I. Preparation and properties of dehydroshikimic reductase
Biochem. J.
80
292-296
1961
Pisum sativum
brenda
Lemos Silva, G.M.; Lourenco, E.J.; Neves, V.A.
Inhibition of shikimate dehydrogenase from heart-of-palm (Euterpe oleracea Mart.)
J. Food Biochem.
9
105-116
1985
Euterpe oleracea
-
brenda
Yaniv, H.; Gilvarg, C.
Aromatic biosynthesis. XIV. 5-dehydroshikimic reductase
J. Biol. Chem.
213
787-795
1955
Escherichia coli
brenda
Maclean, J.; Campbell, S.A.; Pollock, K.; Chackrewarthy, S.; Coggins, J.R.; Lapthorn, A.J.
Crystallization and preliminary X-ray analysis of shikimate dehydrogenase from Escherichia coli
Acta Crystallogr. Sect. D
56
512-515
2000
Escherichia coli
brenda
Lourenco, E.J.; Silva, G.M.L.; Neves, V.A.
Purification and properties of shikimate dehydrogenase from cucumber (Cucumis sativus L.).
J. Agric. Food Chem.
39
458-462
1991
Cucumis sativus
brenda
Diaz, J.; Merino, F.
Shikimate dehydrogenase from pepper (Capsicum annuum) seedlings. Purification and properties
Physiol. Plant.
100
147-152
1997
Capsicum annuum
-
brenda
Lim, S.; Schroder, I.; Monbouquette, H.G.
A thermostable shikimate 5-dehydrogenase from the archaeon Archaeoglobus fulgidus
FEMS Microbiol. Lett.
238
101-106
2004
Archaeoglobus fulgidus
brenda
Ye, S.; Von Delft, F.; Brooun, A.; Knuth, M.W.; Swanson, R.V.; McRee, D.E.
The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode
J. Bacteriol.
185
4144-4151
2003
Haemophilus influenzae, Haemophilus influenzae (P43876)
brenda
Magalhaes, M.L.; Pereira, C.P.; Basso, L.A.; Santos, D.S.
Cloning and expression of functional shikimate dehydrogenase (EC 1.1.1.25) from Mycobacterium tuberculosis H37Rv
Protein Expr. Purif.
26
59-64
2002
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
brenda
Padyana, A.K.; Burley, S.K.
Crystal structure of shikimate 5-dehydrogenase (SDH) bound to NADP: insights into function and evolution
Structure
11
1005-1013
2003
Methanocaldococcus jannaschii (Q58484), Methanocaldococcus jannaschii
brenda
Schoepe, J.; Niefind, K.; Chatterjee, S.; Schomburg, D.
Cloning, expression, purification and preliminary crystallographic characterization of a shikimate dehydrogenase from Corynebacterium glutamicum
Acta Crystallogr. Sect. F
F62
635-637
2006
Corynebacterium glutamicum
brenda
Singh, S.A.; Christendat, D.
Structure of Arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase and implications for metabolic channeling in the shikimate pathway
Biochemistry
45
10406
2006
Arabidopsis thaliana
brenda
Adachi, O.; Ano, Y.; Toyama, H.; Matsushita, K.
Purification and properties of NADP-dependent shikimate dehydrogenase from Gluconobacter oxydans IFO 3244 and its application to enzymatic shikimate production
Biosci. Biotechnol. Biochem.
70
2786-2789
2006
Gluconobacter oxydans, Gluconobacter oxydans IFO 3244
brenda
Han, C.; Wang, L.; Yu, K.; Chen, L.; Hu, L.; Chen, K.; Jiang, H.; Shen, X.
Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori
FEBS J.
273
4682-4692
2006
Helicobacter pylori (Q56S04), Helicobacter pylori, Helicobacter pylori SS1 (Q56S04)
brenda
Zhang, X.; Zhang, S.; Hao, F.; Lai, X.; Yu, H.; Huang, Y.; Wang, H.
Expression, purification and properties of shikimate dehydrogenase from Mycobacterium tuberculosis
J. Biochem. Mol. Biol.
38
624-631
2005
Mycobacterium tuberculosis
brenda
Singh, S.; Korolev, S.; Koroleva, O.; Zarembinski, T.; Collart, F.; Joachimiak, A.; Christendat, D.
Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae
J. Biol. Chem.
280
17101-17108
2005
Haemophilus influenzae
brenda
Fonseca, I.O.; Magalhaes, M.L.; Oliveira, J.S.; Silva, R.G.; Mendes, M.A.; Palma, M.S.; Santos, D.S.; Basso, L.A.
Functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv: purification and characterization
Protein Expr. Purif.
46
429-437
2006
Mycobacterium tuberculosis (A5U5Q2), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (A5U5Q2), Mycobacterium tuberculosis H37Rv
brenda
Vogan, E.
Shikimate dehydrogenase structure reveals novel fold
Structure
11
902-903
2003
Methanocaldococcus jannaschii
brenda
Ding, L.; Hofius, D.; Hajirezaei, M.R.; Fernie, A.R.; Boernke, F.; Sonnewald, U.
Functional analysis of the essential bifunctional tobacco enzyme 3-dehydroquinate dehydratase/shikimate dehydrogenase in transgenic tobacco plants
J. Exp. Bot.
58
2053-2067
2007
Nicotiana tabacum, Nicotiana tabacum (Q6PUF9), Nicotiana tabacum (Q6PUG0)
brenda
Schoepe, J.; Niefind, K.; Schomburg, D.
1.6 A structure of an NAD(+)-dependent quinate dehydrogenase from Corynebacterium glutamicum
Acta Crystallogr. Sect. D
64
803-809
2008
Corynebacterium glutamicum (Q9X5C9)
brenda
Fonseca, I.O.; Silva, R.G.; Fernandes, C.L.; de Souza, O.N.; Basso, L.A.; Santos, D.S.
Kinetic and chemical mechanisms of shikimate dehydrogenase from Mycobacterium tuberculosis
Arch. Biochem. Biophys.
457
123-133
2007
Mycobacterium tuberculosis (A5U5Q2), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (A5U5Q2)
brenda
Gan, J.; Wu, Y.; Prabakaran, P.; Gu, Y.; Li, Y.; Andrykovitch, M.; Liu, H.; Gong, Y.; Yan, H.; Ji, X.
Structural and biochemical analyses of shikimate dehydrogenase AroE from Aquifex aeolicus: implications for the catalytic mechanism
Biochemistry
46
9513-9522
2007
Aquifex aeolicus (O67049), Aquifex aeolicus
brenda
Singh, S.A.; Christendat, D.
The DHQ-dehydroshikimate-SDH-shikimate-NADP(H) complex: insights into metabolite transfer in the shikimate pathway
Cryst. Growth Des.
7
2153-2160
2007
Arabidopsis thaliana
-
brenda
Bagautdinov, B.; Kunishima, N.
Crystal structures of shikimate dehydrogenase AroE from Thermus thermophilus HB8 and its cofactor and substrate complexes: insights into the enzymatic mechanism
J. Mol. Biol.
373
424-438
2007
Thermus thermophilus (Q5SJF8), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SJF8)
brenda
Arcuri, H.A.; Borges, J.C.; Fonseca, I.O.; Pereira, J.H.; Neto, J.R.; Basso, L.A.; Santos, D.S.; de Azevedo, W.F.
Structural studies of shikimate 5-dehydrogenase from Mycobacterium tuberculosis
Proteins
72
720-730
2008
Mycobacterium tuberculosis
brenda
Singh, S.; Stavrinides, J.; Christendat, D.; Guttman, D.S.
A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass
Mol. Biol. Evol.
25
2221-2232
2008
Pseudomonas putida (Q88GF6), Pseudomonas putida (Q88IJ7), Pseudomonas putida (Q88JP1), Pseudomonas putida (Q88K85), Pseudomonas putida (Q88RQ5), Pseudomonas putida KT2440 (Q88IJ7), Pseudomonas putida KT2440 (Q88RQ5), Pseudomonas putida KT 2240 (Q88GF6), Pseudomonas putida KT 2240 (Q88IJ7), Pseudomonas putida KT 2240 (Q88JP1), Pseudomonas putida KT 2240 (Q88K85), Pseudomonas putida KT 2240 (Q88RQ5)
brenda
Han, C.; Hu, T.; Wu, D.; Qu, S.; Zhou, J.; Ding, J.; Shen, X.; Qu, D.; Jiang, H.
X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis
FEBS J.
276
1125-1139
2009
Staphylococcus epidermidis RP62A (Q5HNV1)
brenda
Rodrigues, V.d.a..S.; Basso, L.A.; Santos, D.S.
Homogeneous recombinant Mycobacterium tuberculosis shikimate dehydrogenase production: an essential step towards target-based drug design
Int. J. Biol. Macromol.
45
200-205
2009
Mycobacterium tuberculosis
brenda
Barcellos, G.B.; Caceres, R.A.; de Azevedo, W.F.
Structural studies of shikimate dehydrogenase from Bacillus anthracis complexed with cofactor NADP
J. Mol. Model.
15
147-155
2009
Bacillus anthracis
brenda
Cao, S.; Hu, Z.; Zheng, Y.; Lu, B.
Effect of BTH on anthocyanin content and activities of related enzymes in Strawberry after harvest
J. Agric. Food Chem.
58
5801-5805
2010
Fragaria x ananassa
brenda
Rodrigues, V.S.; Breda, A.; Santos, D.S.; Basso, L.A.
The conserved Lysine69 residue plays a catalytic role in Mycobacterium tuberculosis shikimate dehydrogenase
BMC Res. Notes
2
227
2009
no activity in Homo sapiens, Mycobacterium tuberculosis (P95001), Mycobacterium tuberculosis
brenda
Lee, H.H.
Overexpression, crystallization and preliminary X-ray crystallographic analysis of shikimate dehydrogenase from Archaeoglobus fulgidus
Acta Crystallogr. Sect. F
67
1556-1558
2011
Archaeoglobus fulgidus (O27957), Archaeoglobus fulgidus, Archaeoglobus fulgidus ATCC 49558 (O27957)
brenda
Lee, H.H.
Overexpression, crystallization, and preliminary X-ray crystallographic analysis of shikimate dehydrogenase from Thermotoga maritima
Acta Crystallogr. Sect. F
67
824-826
2011
Thermotoga maritima (Q9WYI1), Thermotoga maritima, Thermotoga maritima ATCC 43589 (Q9WYI1)
brenda
Kubota, T.; Tanaka, Y.; Hiraga, K.; Inui, M.; Yukawa, H.
Characterization of shikimate dehydrogenase homologues of Corynebacterium glutamicum
Appl. Microbiol. Biotechnol.
97
8139-8149
2013
Corynebacterium glutamicum (A4QB65), Corynebacterium glutamicum (A4QEK4), Corynebacterium glutamicum, Corynebacterium glutamicum JCM 18229 (A4QB65), Corynebacterium glutamicum JCM 18229 (A4QEK4)
brenda
Lee, H.H.
High-resolution structure of shikimate dehydrogenase from Thermotoga maritima reveals a tightly closed conformation
Mol. Cells
33
229-233
2012
Thermotoga maritima (Q9WYI1), Thermotoga maritima, Thermotoga maritima ATCC 43589 (Q9WYI1)
brenda
Peek, J.; Christendat, D.
The shikimate dehydrogenase family: functional diversity within a conserved structural and mechanistic framework
Arch. Biochem. Biophys.
566
85-99
2015
Escherichia coli, Helicobacter pylori, Staphylococcus aureus, Mycobacterium tuberculosis, Populus trichocarpa, Corynebacterium glutamicum (A4QB65), Archaeoglobus fulgidus (O27957), Aquifex aeolicus (O67049), Aspergillus nidulans (P07547), Staphylococcus epidermidis (Q5HNV1), Toxoplasma gondii (Q6W3D0), Pseudomonas putida (Q88IJ7), Arabidopsis thaliana (Q9SQT8), Archaeoglobus fulgidus ATCC 49558 (O27957), Aspergillus nidulans FGSC A4 (P07547), Staphylococcus epidermidis ATCC 35984 (Q5HNV1), Pseudomonas putida KT 2240 (Q88IJ7)
brenda
Prus-Glowacki, W.; Sukovata, L.; Lewandowska-Wosik, A.; Nowak-Bzowy, R.
Shikimate dehydrogenase (E.C. 1.1.1.25 ShDH) alleles as potential markers for flowering phenology in Pinus sylvestris
Dendrobiology
73
153-162
2015
Pinus sylvestris
-
brenda
Guo, J.; Carrington, Y.; Alber, A.; Ehlting, J.
Molecular characterization of quinate and shikimate metabolism in Populus trichocarpa
J. Biol. Chem.
289
23846-23858
2014
Populus trichocarpa, Populus trichocarpa Nisqually-1
brenda
Peek, J.; Shi, T.; Christendat, D.
Identification of novel polyphenolic inhibitors of shikimate dehydrogenase (AroE)
J. Biomol. Screen.
19
1090-1098
2014
Pseudomonas putida (Q88RQ5), Pseudomonas putida, Arabidopsis thaliana (Q9SQT8), Arabidopsis thaliana, Pseudomonas putida KT 2240 (Q88RQ5)
brenda
Bontpart, T.; Marlin, T.; Vialet, S.; Guiraud, J.L.; Pinasseau, L.; Meudec, E.; Sommerer, N.; Cheynier, V.; Terrier, N.
Two shikimate dehydrogenases, VvSDH3 and VvSDH4, are involved in gallic acid biosynthesis in grapevine
J. Exp. Bot.
67
3537-3550
2016
Vitis vinifera (A0A168S2B8), Vitis vinifera (A0A168S2G5), Vitis vinifera (A0A168S2H6), Vitis vinifera (D7TUX1)
brenda
Peek, J.; Castiglione, G.; Shi, T.; Christendat, D.
Isolation and molecular characterization of the shikimate dehydrogenase domain from the Toxoplasma gondii AROM complex
Mol. Biochem. Parasitol.
194
16-19
2014
Toxoplasma gondii
brenda
Avitia-Dominguez, C.; Sierra-Campos, E.; Salas-Pacheco, J.M.; Najera, H.; Rojo-Dominguez, A.; Cisneros-Martinez, J.; Tellez-Valencia, A.
Inhibition and biochemical characterization of methicillin-resistant Staphylococcus aureus shikimate dehydrogenase: an in silico and kinetic study
Molecules
19
4491-4509
2014
Staphylococcus aureus, Staphylococcus aureus ATCC MRSA252
brenda
Li, Z.; Liu, Y.; Bai, X.; Deng, Q.; Wang, J.; Zhang, G.; Xiao, C.; Mei, Y.; Wang, Y.
SAR studies on 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles as inhibitors of Mtb shikimate dehydrogenase for the development of novel antitubercular agents
RSC Adv.
5
97089-97101
2015
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
-
brenda
Zhang, J.; ten Pierick, A.; van Rossum, H.M.; Seifar, R.M.; Ras, C.; Daran, J.M.; Heijnen, J.J.; Wahl, S.A.
Determination of the cytosolic NADPH/NADP ratio in Saccharomyces cerevisiae using shikimate dehydrogenase as sensor reaction
Sci. Rep.
5
12846
2015
Escherichia coli (P15770)
brenda
Habashi, R.; Hacham, Y.; Dhakarey, R.; Matityahu, I.; Holland, D.; Tian, L.; Amir, R.
Elucidating the role of shikimate dehydrogenase in controlling the production of anthocyanins and hydrolysable tannins in the outer peels of pomegranate
BMC Plant Biol.
19
476
2019
Punica granatum (A0A6P8EJ47), Punica granatum
brenda
Enriquez-Mendiola, D.; Tellez-Valencia, A.; Sierra-Campos, E.; Campos-Almazan, M.; Valdez-Solana, M.; Gomez Palacio-Gastelum, M.; Avitia-Dominguez, C.
Kinetic and molecular dynamic studies of inhibitors of shikimate dehydrogenase from methicillin-resistant Staphylococcus aureus
Chem. Biol. Drug Des.
94
1504-1517
2019
Staphylococcus aureus
brenda
Li, J.; Wu, G.; Fu, Q.; Ge, H.; Liu, S.; Li, X.; Cheng, B.
Exploring the influence of conserved lysine69 on the catalytic activity of the Helicobacter pylori shikimate dehydrogenase a combined QM/MM and MD simulations
Comput. Biol. Chem.
83
107098
2019
Helicobacter pylori
brenda
Huang, K.; Li, M.; Liu, Y.; Zhu, M.; Zhao, G.; Zhou, Y.; Zhang, L.; Wu, Y.; Dai, X.; Xia, T.; Gao, L.
Functional analysis of 3-dehydroquinate dehydratase/shikimate dehydrogenases involved in shikimate pathway in Camellia sinensis
Front. Plant Sci.
10
1268
2019
Camellia sinensis (A0A3G3BK08), Camellia sinensis
brenda
Hyskova, V.; Pliskova, V.; Cerveny, V.; Ryslava, H.
NADP-dependent enzymes are involved in response to salt and hypoosmotic stress in cucumber plants
Gen. Physiol. Biophys.
36
247-258
2017
Cucumis sativus (A0A0A0LQ48)
brenda
Wang, K.; Zhu, M.; Tang, Y.; Liu, J.; Yan, F.; Yu, Z.; Zhu, J.
Integration of virtual screening and susceptibility test to discover active-site subpocket-specific biogenic inhibitors of Helicobacter pylori shikimate dehydrogenase
Int. Microbiol.
22
69-80
2019
Helicobacter pylori (Q56S04), Helicobacter pylori
brenda
Skariyachan, S.; Manjunath, M.; Bachappanavar, N.
Screening of potential lead molecules against prioritised targets of multi-drug-resistant-Acinetobacter baumannii - insights from molecular docking, molecular dynamic simulations and in vitro assays
J. Biomol. Struct. Dyn.
37
1146-1169
2019
Acinetobacter baumannii
brenda
Punkvang, A.; Kamsri, P.; Mulholland, A.; Spencer, J.; Hannongbua, S.; Pungpo, P.
Simulations of shikimate dehydrogenase from Mycobacterium tuberculosis in complex with 3-dehydroshikimate and NADPH suggest strategies for MtbSDH inhibition
J. Chem. Inf. Model.
59
1422-1433
2019
no activity in Homo sapiens, Mycobacterium tuberculosis (A0A045GU47), Mycobacterium tuberculosis
brenda
Diaz-Quiroz, D.C.; Cardona-Felix, C.S.; Viveros-Ceballos, J.L.; Reyes-Gonzalez, M.A.; Bolivar, F.; Ordonez, M.; Escalante, A.
Synthesis, biological activity and molecular modelling studies of shikimic acid derivatives as inhibitors of the shikimate dehydrogenase enzyme of Escherichia coli
J. Enzyme Inhib. Med. Chem.
33
397-404
2018
Escherichia coli (P15770), Escherichia coli
brenda
Garcia, S.; Flores, N.; De Anda, R.; Hernandez, G.; Gosset, G.; Bolivar, F.; Escalante, A.
The role of the ydiB gene, which encodes quinate/shikimate dehydrogenase, in the production of quinic, dehydroshikimic and shikimic acids in a PTS-strain of Escherichia coli
J. Mol. Microbiol. Biotechnol.
27
11-21
2017
Escherichia coli (P0A6D5), Escherichia coli PB12 (P0A6D5)
brenda
Gritsunov, A.; Peek, J.; Diaz Caballero, J.; Guttman, D.; Christendat, D.
Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases
Plant J.
95
812-822
2018
Arabidopsis thaliana (Q9SQT8)
brenda
Carrington, Y.; Guo, J.; Le, C.H.; Fillo, A.; Kwon, J.; Tran, L.T.; Ehlting, J.
Evolution of a secondary metabolic pathway from primary metabolism shikimate and quinate biosynthesis in plants
Plant J.
95
823-833
2018
Chlamydomonas reinhardtii, Physcomitrium patens, Pinus taeda, Populus trichocarpa, Rhodopirellula baltica, Selaginella moellendorffii
brenda
Tahara, K.; Nishiguchi, M.; Funke, E.; Miyazawa, S.I.; Miyama, T.; Milkowski, C.
Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species Eucalyptus camaldulensis
Planta
253
3
2020
Eucalyptus camaldulensis (A0A5H2WVH6), Eucalyptus camaldulensis (A0A5H2WZU5), Eucalyptus camaldulensis (A0A5H2X4C4), Eucalyptus camaldulensis
brenda
Garcia-Guevara, F.; Bravo, I.; Martinez-Anaya, C.; Segovia, L.
Cofactor specificity switch in shikimate dehydrogenase by rational design and consensus engineering
Protein Eng. Des. Sel.
30
533-541
2017
Escherichia coli (P15770), Escherichia coli
brenda