1.1.1.52: 3alpha-hydroxycholanate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 3alpha-hydroxycholanate dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

alpha-hydroxy-cholanate dehydrogenase, dehydrogenase, 3alpha-hydroxycholanate

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.52 3alpha-hydroxycholanate dehydrogenase (NAD+)

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All data fields related to EC 1.1.1.52
Results	in table
1	Activating Compound
7	AA Sequence
1	CAS Registry Number
2	Cofactor
1	Localization
1	Natural Substrates/ Products (Substrates)
1	Organism
5	Pathway
2	PDB ID
1	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
2	Reaction Type
1	Reference
8	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

Substrates Products on EC 1.1.1.52 - 3alpha-hydroxycholanate dehydrogenase (NAD+)

for references in articles please use BRENDA:EC1.1.1.52

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3alpha-hydroxy-5beta-cholanate + NAD+

3-oxo-5beta-cholanate + NADH

2 entries

3alpha-hydroxy-bis-norcholanic acid + NAD+

3-oxo-bis-norcholanic acid + NADH

Escherichia sp.

287082

Substrates: oxidation at the same rate as hydroxycholanic acid
Products: -

3alpha-hydroxy-norcholanic acid + NAD+

3-oxo-norcholanic acid + NADH

Escherichia sp.

287082

Substrates: oxidation at the same rate as hydroxycholanic acid
Products: -

cholic acid + NAD+

7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid + NADH

Escherichia sp.

287082

Substrates: oxidation at the same rate as hydroxycholanic acid
Products: -

dehydrocholic acid + NADH

3-hydroxy-7,12-dihydroxy-5beta-cholan-24-oic acid + NAD+

Escherichia sp.

287082

Substrates: i.e. 3,7,12-trioxocholan-24-oic acid
Products: -

deoxycholic acid + NAD+

12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+

Escherichia sp.

287082

Substrates: oxidation at the same rate as hydroxycholanic acid
Products: -

additional information

Escherichia sp.

287082

Substrates: no substrates: androsterone and tetrahydrocortisone, methylation of carboxyl group or reduction to alcohol inactivates
Products: -