1.1.99.20: alkan-1-ol dehydrogenase (acceptor)

This is an abbreviated version!
For detailed information about alkan-1-ol dehydrogenase (acceptor), go to the full flat file.

Word Map on EC 1.1.99.20

Reaction

primary alcohol
+
acceptor
=
aldehyde
 +
reduced acceptor

Synonyms

polyethylene glycol dehydrogenase, dehydrogenase, polyethylene glycol, PEGDH, PEG-DH, alkan-1-ol dehydrogenase, alkan-1-ol:acceptor oxidoreductase, ethoxy chain nonylphenol dehydrogenase, NPEO-DH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.99 With unknown physiological acceptors
                1.1.99.20 alkan-1-ol dehydrogenase (acceptor)

Engineering

Engineering on EC 1.1.99.20 - alkan-1-ol dehydrogenase (acceptor)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H465A
the mutant shows no significant change in affinity toward substrates, but the apparent kcat values decrease to approximately 1/20 of the apparent kcat value of the wild type enzyme
N90A
the mutant shows the less kcat values toward NPEOav10 than toward PEG-1000
N507A
inactive
H465A/N507A
inactive
N509A
the mutant shows the less kcat values toward NPEOav10 than toward PEG-1000