1.14.11.53: mRNA N6-methyladenine demethylase

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For detailed information about mRNA N6-methyladenine demethylase, go to the full flat file.

Word Map on EC 1.14.11.53

1.14.11.53

demethylation

demethylases

mettl14

reader

writer

erasers

ythdf1

methyltransferases

epitranscriptomic

m6a-related

fto-mediated

m6a-dependent

hnrnpa2b1

methyltransferase-like

hnrnpc

lasso

m6a-modified

igf2bp1

merip

merip-seq

m6a-binding

Reaction

Synonyms

AlkB homolog 5, ALKBH10B, ALKBH5, ALKBH5 demethylase, ALKBH9B, alkylation repair homolog protein 5, fat mass and obesity-associated enzyme, fat mass and obesity-associated protein, FTO, m6A mRNA demethylase, m6A RNA demethylase, m6A-RNA demethylase, N6-methyladenosine demethylase, RNA N6-methyladenine demethylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.53 mRNA N6-methyladenine demethylase

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Results	in table
1918	AA Sequence
7	Application
10	Cloned(Commentary)
6	Crystallization (Commentary)
777	Disease/ Diagnostics
4	Expression
26	General Information
2	General Stability
11	IC50 Value
23	Inhibitors
10	kcat/KM [mM/s]
11	KM Value [mM]
8	Localization
8	Metals/Ions
2	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
45	Organism
14	PDB ID
6	pH Optimum
1	Posttranslational Modification
21	Protein Variants
12	Purification (Commentary)
1	Reaction
44	Reference
42	Source Tissue
53	Substrates and Products (Substrate)
3	Subunits
53	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
10	Turnover Number [1/s]

Posttranslational Modification

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Posttranslational Modification on EC 1.14.11.53 - mRNA N6-methyladenine demethylase

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sumoylation

Homo sapiens

Q6P6C2

ROS promotes ALKBH5 sumoylation, which blocks m6A demethylase activity by inhibition of substrate accessibility. Overexpression of sumoylation-deficient ALKBH5 blocks ROS-induced mRNA m6A methylation, leading to a significant delay of DNA repair and increase of cell apoptosis

765485