1.14.11.73: [protein]-arginine 3-hydroxylase
This is an abbreviated version!
For detailed information about [protein]-arginine 3-hydroxylase, go to the full flat file.
Reaction
Synonyms
JMJD5, KDM8
ECTree
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Substrates Products
Substrates Products on EC 1.14.11.73 - [protein]-arginine 3-hydroxylase
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REACTION DIAGRAM
[RCCD1]-L-arginine + 2-oxoglutarate + O2
[RCCD1]-(3R)-3-hydroxy-L-arginine + succinate + CO2
substrate i.e. regulator of chromosome condensation domain-containing protein 1
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[RPS6]-L-arginine + 2-oxoglutarate + O2
[RPS6]-(3R)-3-hydroxy-L-arginine + succinate + CO2
substrate i.e. ribosomal protein S6
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JMJD5 catalyses stereoselective C-3 hydroxylation of arginine residues in sequences from human regulator of chromosome condensation domain-containing protein 1 (RCCD1) and ribosomal protein S6 (RPS6)
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additional information
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both isoforms JMJD5 and JMJD7 bind to H3R2(me2) and H4R3(me2) peptides with similar binding affinities
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