1.14.12.24: 2,4-dinitrotoluene dioxygenase
This is an abbreviated version!
For detailed information about 2,4-dinitrotoluene dioxygenase, go to the full flat file.
Word Map on EC 1.14.12.24
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1.14.12.24
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burkholderia
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4-methyl-5-nitrocatechol
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cepacia
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monooxygenase
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naphthalene
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2-nitrotoluene
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fission
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dinitrotoluenes
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sphingomonas
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nitroaromatic
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extradiol
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nahac
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vitreoscilla
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regiospecificity
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enantiomeric
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priority
- 1.14.12.24
- burkholderia
- 4-methyl-5-nitrocatechol
- cepacia
- monooxygenase
- naphthalene
- 2-nitrotoluene
-
fission
-
dinitrotoluenes
- sphingomonas
-
nitroaromatic
-
extradiol
- nahac
- vitreoscilla
-
regiospecificity
-
enantiomeric
-
priority
Reaction
Synonyms
2,4-dinitrotoluene dioxygenase, 2,4-DNT dioxygenase, 2,4-DNTDO, DDO, DNT dioxygenase, dntA, DntAc, DNTDO
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Systematic Name
Systematic Name on EC 1.14.12.24 - 2,4-dinitrotoluene dioxygenase
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2,4-dinitrotoluene,NADH:oxygen oxidoreductase (4,5-hydroxylating, nitrite-releasing)
This enzyme, characterized from the bacterium Burkholderia sp. strain DNT, is a member of the naphthalene family of bacterial Rieske non-heme iron dioxygenases. It comprises a multicomponent system, containing a Rieske [2Fe-2S] ferredoxin, an NADH-dependent flavoprotein reductase (EC 1.18.1.3, ferredoxin---NAD+ reductase), and an alpha3beta3 oxygenase. The enzyme forms a cis-dihydroxylated product that spontaneously rearranges to form a catechol with accompanying release of nitrite. It does not act on nitrobenzene. cf. EC 1.14.12.23, nitroarene dioxygenase.