1.14.13.180: aklavinone 12-hydroxylase

This is an abbreviated version!
For detailed information about aklavinone 12-hydroxylase, go to the full flat file.

Reaction

Synonyms

aklavinone 12-hydroxylase, DnrF, RdmE

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

1.14.13.180 aklavinone 12-hydroxylase

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Results	in table
47	AA Sequence
1	Application
5	Cloned(Commentary)
5	Cofactor
2	Crystallization (Commentary)
2	General Information
2	Inhibitors
4	KM Value [mM]
3	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
10	Organism
5	Pathway
1	pH Optimum
1	pI Value
5	Protein Variants
1	Purification (Commentary)
1	Reaction
10	Reference
12	Substrates and Products (Substrate)
4	Subunits
11	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

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Application on EC 1.14.13.180 - aklavinone 12-hydroxylase

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synthesis

Streptomyces peucetius

P32009

biosynthesis of carminic acid from glucose in engineered Escherichia coli. Expression of an optimized type II polyketide synthase machinery from Photorhabdus luminescens enables a high-level production of flavokermesic acid upon coexpression of the cyclases ZhuI and ZhuJ from Streptomyces sp. R1128. Mutants of aklavinone 12-hydroxylase (DnrF) from Streptomyces peucetius and C-glucosyltransferase (GtCGT) from Gentiana triflora with 2-5fold enhanced conversion efficiencies can perform hydroxylation and C-glucosylation of flavokermesic acid, respectively, resulting in 0.63 mg/l of carminic acid production from glucose

764979