1.5.3.6: (R)-6-hydroxynicotine oxidase
This is an abbreviated version!
For detailed information about (R)-6-hydroxynicotine oxidase, go to the full flat file.
Word Map on EC 1.5.3.6
-
1.5.3.6
-
fad
-
arthrobacter
-
oxidans
-
flavinylation
-
holoenzyme
-
flavin
-
flavoproteins
-
6-hydroxy-l-nicotine
-
flavoenzymes
-
apoenzyme
-
nicotinovorans
-
nicotine-degrading
-
l-nicotine
-
dimethylglycine
-
glycerol-3-p
-
cotranslational
-
fad-binding
-
l-enantiomer
- 1.5.3.6
- fad
- arthrobacter
- oxidans
-
flavinylation
-
holoenzyme
- flavin
- flavoproteins
- 6-hydroxy-l-nicotine
-
flavoenzymes
-
apoenzyme
- nicotinovorans
-
nicotine-degrading
- l-nicotine
- dimethylglycine
-
glycerol-3-p
-
cotranslational
-
fad-binding
-
l-enantiomer
Reaction
Synonyms
6-HDNO, 6-hydroxy-D-nicotine oxidase, D-6-hydroxynicotine oxidase
ECTree
1.5.3.6 (R)-6-hydroxynicotine oxidaseAdvanced search results
results (
results (General Information
General Information on EC 1.5.3.6 - (R)-6-hydroxynicotine oxidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
metabolism
Q8GAG1
a network of hydrogen-bonded residues in the active site is involved in binding the neutral form of the amine substrate, followed by the transfer of a hydride from the amine to the flavin. There is no solvent isotope effect on the kcat/Kamine value with either (R)-6-hydroxynicotine or the slower substrate (R)-6-hydroxynornicotine. Only the neutral form of the substrate and the correctly protonated form of the enzyme bind. The active-site residues Lys348, Glu350, and Glu352 are all properly positioned for substrate binding
