1.6.5.10: NADPH dehydrogenase (quinone)
This is an abbreviated version!
For detailed information about NADPH dehydrogenase (quinone), go to the full flat file.
Word Map on EC 1.6.5.10
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1.6.5.10
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neutrophil
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endothelial
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p47phox
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phagocyte
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apocynin
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dismutase
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artery
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gp91phox
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cardiovascular
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nicotinamide
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hypertension
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angiotensin
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catalase
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oxidases
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cardiac
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leukocyte
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phorbol
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monocyte
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mapks
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sod
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aortic
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granulomatous
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diphenyleneiodonium
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diphenylene
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pma
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iodonium
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rac1
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atherosclerosis
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chemiluminescence
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phagocytosis
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xanthine
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polymorphonuclear
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myristate
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microglial
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myeloperoxidase
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ii-induced
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dihydroethidium
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endothelium-dependent
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flavocytochrome
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zymosan
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peroxynitrite
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phagosomes
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tempol
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fmlp
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ros-dependent
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microbicidal
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nadph-oxidase
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nitrotyrosine
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lucigenin
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medicine
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fmlp-induced
- 1.6.5.10
- neutrophil
- endothelial
- p47phox
- phagocyte
- apocynin
- dismutase
- artery
- gp91phox
- cardiovascular
- nicotinamide
- hypertension
- angiotensin
- catalase
- oxidases
- cardiac
- leukocyte
-
phorbol
- monocyte
- mapks
- sod
- aortic
- granulomatous
- diphenyleneiodonium
-
diphenylene
- pma
- iodonium
- rac1
- atherosclerosis
-
chemiluminescence
-
phagocytosis
- xanthine
-
polymorphonuclear
- myristate
- microglial
- myeloperoxidase
-
ii-induced
- dihydroethidium
-
endothelium-dependent
-
flavocytochrome
- zymosan
- peroxynitrite
-
phagosomes
-
tempol
- fmlp
-
ros-dependent
-
microbicidal
- nadph-oxidase
-
nitrotyrosine
- lucigenin
- medicine
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fmlp-induced
Reaction
Synonyms
AKR1C9, ArsH, azoreductase, CBR4, dehydrogenase, reduced nicotinamide adenine dinucleotide phosphate (quinone), EC 1.6.99.6, MdaB, More, NADPH oxidase, NADPH quinone oxidoreductase, NADPH quinone oxidoreductase 1, NADPH quinone reductase, NADPH-dependent quinone reductase, NADPH-quinone oxidoreductase, NADPH:quinone oxidoreductase 1, NQO1, PA1225, PpAzoR, XAC2229, Zta1p
ECTree
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Inhibitors
Inhibitors on EC 1.6.5.10 - NADPH dehydrogenase (quinone)
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(N-methyl-4'-pyridyl) porphyrin
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iron tetrakis, FeTMPyP, no inhibitory activity
1,4-Naphthoquinone
substrate inhibition at concentrations above 0.025 mM
Cibacron blue F3GA
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the 1,4-naphthoquinone activity of CBR4 is potently inhibited, competitive with respect to NADPH
coenzyme Q0
substrate inhibition at concentrations above 0.025 mM
diphenylene iodonium
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inhibition of the NADPH oxidase complex activity reduces the increase of superoxide production induced by palmitic acid
Procion red HE3B
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the 1,4-naphthoquinone activity of CBR4 is potently inhibited, competitive with respect to NADPH
tetramethyl-1,4-benzoquinone
substrate inhibition at concentrations above 0.025 mM
4-(2-aminoethyl)benzenesulfonylfluoride
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0.206 mM, 50% inhibition, noncompetitive vs. NADPH, competitive vs. p47-phox in the concentration range of 0.5-2.0 mM
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the 1,4-naphthoquinone activity of CBR4 is potently inhibited, competitive with respect to NADPH
NADP+
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NADP+ acts as a competitive inhibitor for NADPH binding at the active site of an enzyme
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insensitive to 4-chloromercuribenzoate at 100 microM, heavy metals such as Cu2+, Co2+, Cd2+ and Mn2+ at 10 microM each, and chelating agents such as EDTA, o-phenanthroline and diethyldithiocarbamate at 100 microM each
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additional information
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the enzyme is insensitive to dicuomarol and quercetin, potent inhibitors of cytosolic quinone reductases
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