2.4.2.2: pyrimidine-nucleoside phosphorylase

This is an abbreviated version!
For detailed information about pyrimidine-nucleoside phosphorylase, go to the full flat file.

Word Map on EC 2.4.2.2

2.4.2.2

purine

deaminase

inosine

hypoxanthine

xanthine

phosphorolysis

phosphorylases

synthesis

2'-deoxyribonucleosides

2.4.2.1

5-fluoro-2'-deoxyuridine

ribose-1-phosphate

medicine

Reaction

Synonyms

AmPyNP, BbPyNP, BfPyNP, BsPyNP, deoA, EC 2.4.2.23, GsPyNP, GtPyNP, LpPyNP, nucleoside phosphorylase, PDP, phosphorylase, pyrimidine nucleoside, Py-NPase, PYNP, pynpase, pyrimidine nucleoside phosphorylase, pyrimidine ribonucleoside phosphorylase, pyrimidine-nucleoside phosphorylase, pyrimidine/purine nucleoside phosphorylase, TTHA1771, TtPyNP, udp, UPase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.2 pyrimidine-nucleoside phosphorylase

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Results	in table
1	Activating Compound
13423	AA Sequence
8	Application
1	CAS Registry Number
18	Cloned(Commentary)
6	Crystallization (Commentary)
85	Disease/ Diagnostics
1	Expression
9	General Information
3	General Stability
10	IC50 Value
7	Inhibitors
12	kcat/KM [mM/s]
2	Ki Value [mM]
50	KM Value [mM]
7	Molecular Weight [Da]
71	Natural Substrates/ Products (Substrates)
136	Organism
1	Oxidation Stability
5	Pathway
10	PDB ID
19	pH Optimum
3	pH Range
2	pH Stability
6	Protein Variants
11	Purification (Commentary)
4	Reaction
5	Reaction Type
45	Reference
1	Renatured (Commentary)
2	Source Tissue
15	Specific Activity [micromol/min/mg]
2	Storage Stability
194	Substrates and Products (Substrate)
11	Subunits
62	Synonyms
1	Systematic Name
15	Temperature Optimum [°C]
5	Temperature Range [°C]
19	Temperature Stability [°C]
20	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.4.2.2 - pyrimidine-nucleoside phosphorylase

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3,5-bis-(4-chlorobenzoyl)-alpha-D-ribose 1-phosphate

Mycoplasma hyorhinis

competitive inhibition with regard to inosine

721554

5-benzylacyclouridine

2 entries

5-chloro-6-(1-[2-iminopyrrolidinyl]methyl)uracil

7-deazaxanthine

uridine

Haemophilus influenzae

above 15 mM, competitive inhibition of cleavage of 5-bromodeoxyuridine

638532

additional information

Escherichia coli

inhibitory effects between pyrimidines and analogues

659906