2.4.2.2: pyrimidine-nucleoside phosphorylase
This is an abbreviated version!
For detailed information about pyrimidine-nucleoside phosphorylase, go to the full flat file.
Reaction
Synonyms
AmPyNP, BbPyNP, BfPyNP, BsPyNP, deoA, EC 2.4.2.23, GsPyNP, GtPyNP, LpPyNP, nucleoside phosphorylase, PDP, phosphorylase, pyrimidine nucleoside, Py-NPase, PYNP, pynpase, pyrimidine nucleoside phosphorylase, pyrimidine ribonucleoside phosphorylase, pyrimidine-nucleoside phosphorylase, pyrimidine/purine nucleoside phosphorylase, TTHA1771, TtPyNP, udp, UPase
ECTree
Advanced search results
Reference
Reference on EC 2.4.2.2 - pyrimidine-nucleoside phosphorylase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Hamamoto, T.; Noguchi, T.; Midorikawa, Y.
Purification and characterization of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus TH 6-2
Biosci. Biotechnol. Biochem.
60
1179-1180
1996
Haemophilus influenzae, Haemophilus influenzae TH 6-2
Scocca, J.J.
Purification and substrate specificity of pyrimidine nucleoside phosphorylase from Haemophilus influenzae
J. Biol. Chem.
246
6606-6610
1971
Haemophilus influenzae
Saunders, P.P.; Wilson, B.A.; Saunders, G.F.
Purification and comparative properties of a pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus
J. Biol. Chem.
244
3691-3697
1969
Geobacillus stearothermophilus
Pugmire, M.J.; Ealick, S.E.
The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation
Structure
6
1467-1479
1998
Geobacillus stearothermophilus
Zhou, M.; Pugmire, M.J.; Vuong, B.Q.; Ealick, S.E.
Cloning, expression and crystallization of pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus
Acta Crystallogr. Sect. D
55
287-290
1999
Geobacillus stearothermophilus
Scocca, J.J.
Pyrimidine nucleoside phosphorylase from Haemophilus influenzae
Methods Enzymol.
51
432-437
1978
Haemophilus influenzae
Hori, N.; Watanabe, M.; Yamazaki, Y.; Mikami, Y.
Purification and characterization of thermostable pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus
Agric. Biol. Chem.
54
763-768
1990
Geobacillus stearothermophilus, Geobacillus stearothermophilus JTS 859
-
Zaks, A.; Dodds, D.R.
Application of biocatalysts and biotransformation to the synthesis of pharmaceuticals
Drug Discov. Today
2
513-531
1997
Pectobacterium carotovorum
-
Panova, N.G.; Shcheveleva, E.V.; Alexeev, C.S.; Mukhortov, V.G.; Zuev, A.N.; Mikhailov, S.N.; Esipov, R.S.; Chuvikovsky, D.V.; Miroshnikov, A.I.
Use of 4-thiouridine and 4-thiothymidine in studies on pyrimidine nucleoside phosphorylases
Mol. Biol.
38
770-776
2004
Escherichia coli
-
Shimizu, K.; Kunishima, N.
Purification, crystallization and preliminary X-ray diffraction study on pyrimidine nucleoside phosphorylase TTHA1771 from Thermus thermophilus HB8
Acta Crystallogr. Sect. F
63
308-310
2007
Thermus thermophilus, Thermus thermophilus (Q5SHF9), Thermus thermophilus HB8 / ATCC 27634 / DSM 579, Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SHF9)
Gao, X.F.; Huang, X.R.; Sun, C.C.
Role of each residue in catalysis in the active site of pyrimidine nucleoside phosphorylase from Bacillus subtilis: a hybrid QM/MM study
J. Struct. Biol.
154
20-26
2006
Bacillus subtilis (P39142), Bacillus subtilis
Nishioka, M.; Miyamoto, H.; Kurita, N.; Higashijima, J.; Yoshikawa, K.; Miyatani, T.; Shimada, M.
Pyrimidine nucleoside phosphorylase and dihydropyrimidine dihydrogenase activities as predictive factors for the efficacy of doxifluridine together with mitomycin C as adjuvant chemotherapy in primary colorectal cancer
Hepatogastroenterology
54
1089-1093
2007
Homo sapiens
Tang, Y.; Ni, M.; Wu, W.; Sun, J.; Zhou, C.
Biotransformation of the antitumor intermediate 5-fluorouridine by recombinant Escherichia coli with high pyrimidine nucleoside phosphorylase activity
Biocatal. Biotransform.
28
130-136
2010
Klebsiella aerogenes, Klebsiella aerogenes CMCC 45103
-
Vande Voorde, J.; Gago, F.; Vrancken, K.; Liekens, S.; Balzarini, J.
Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues
Biochem. J.
445
113-123
2012
Mycoplasma hyorhinis
Vande Voorde, J.; Quintiliani, M.; McGuigan, C.; Liekens, S.; Balzarini, J.
Inhibition of pyrimidine and purine nucleoside phosphorylases by a 3,5-dichlorobenzoyl-substituted 2-deoxy-D-ribose-1-phosphate derivative
Biochem. Pharmacol.
83
1358-1363
2012
Mycoplasma hyorhinis
Tran, T.H.; Christoffersen, S.; Allan, P.W.; Parker, W.B.; Piskur, J.; Serra, I.; Terreni, M.; Ealick, S.E.
The crystal structure of Streptococcus pyogenes uridine phosphorylase reveals a distinct subfamily of nucleoside phosphorylases
Biochemistry
50
6549-6558
2011
Streptococcus pyogenes (Q5XA29), Streptococcus pyogenes
Szeker, K.; Zhou, X.; Schwab, T.; Casanueva, A.; Cowan, D.; Mikhailopulo, I.; Neubauer, P.
Comparative investigations on thermostable pyrimidine nucleoside phosphorylases from Geobacillus thermoglucosidasius and Thermus thermophilus
J. Mol. Catal. B
84
27-34
2012
Parageobacillus thermoglucosidasius, Thermus thermophilus (Q72HS4), Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 (Q72HS4)
-
Serra, I.; Bavaro, T.; Cecchini, D.; Daly, S.; Albertini, A.; Terreni, M.; Ubiali, D.
A comparison between immobilized pyrimidine nucleoside phosphorylase from Bacillus subtilis and thymidine phosphorylase from Escherichia coli in the synthesis of 5-substituted pyrimidine 2'-deoxyribonucleosides
J. Mol. Catal. B
95
16-22
2013
Bacillus subtilis
-
Vande Voorde, J.; Liekens, S.; Gago, F.; Balzarini, J.
The pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis and how it may affect nucleoside-based therapy
Nucleosides Nucleotides Nucleic Acids
33
394-402
2014
Mycoplasma hyorhinis, Mycoplasma hyorhinis ATCC 17981
Balaev, V.V.; Prokofev, I.I.; Gabdoulkhakov, A.G.; Betzel, C.; Lashkov, A.A.
Crystal structure of pyrimidine-nucleoside phosphorylase from Bacillus subtilis in complex with imidazole and sulfate
Acta Crystallogr. Sect. F
74
193-197
2018
Bacillus subtilis (P39142), Bacillus subtilis
Liu, Y.K.; Lin, T.H.; Liu, P.F.
ATP alters protein folding and function of Escherichia coli uridine phosphorylase
Arch. Biochem. Biophys.
634
11-20
2017
Escherichia coli (P0C037)
Kamel, S.; Thiele, I.; Neubauer, P.; Wagner, A.
Thermophilic nucleoside phosphorylases their properties, characteristics and applications
Biochim. Biophys. Acta
1868
140304
2020
Parageobacillus thermoglucosidasius (A0A178U4P5), Bacillus subtilis (P39142), Geobacillus stearothermophilus (P77836), Thermus thermophilus (Q72HS4), Bacillus subtilis 168 (P39142)
Liu, K.; Zhou, Y.; Zhang, J.; Chu, J.; Zhang, Y.; He, B.
A thermostable pyrimidine nucleoside phosphorylase from Brevibacillus borstelensis LK01 for synthesizing halogenated nucleosides
Biotechnol. Lett.
39
1903-1910
2017
Siminovitchia fordii, Serratia marcescens (A0A080UUN2), Aneurinibacillus migulanus (A0A0D1XZI7), Lacticaseibacillus paracasei (A0A0E2M090), Brevibacillus borstelensis (A0A1S5VH74), Brevibacillus borstelensis, Serratia marcescens MH6 (A0A080UUN2), Brevibacillus borstelensis LK01 (A0A1S5VH74), Aneurinibacillus migulanus U603 (A0A0D1XZI7)
Alexeev, C.S.; Sivets, G.G.; Safonova, T.N.; Mikhailov, S.N.
Substrate specificity of E. coli uridine phosphorylase. Further evidences of high-syn conformation of the substrate in uridine phosphorolysis
Nucleosides Nucleotides Nucleic Acids
36
107-121
2017
Escherichia coli (P0C037)
Giessmann, R.; Krausch, N.; Kaspar, F.; Bournazou, M.; Wagner, A.; Neubauer, P.; Gimpel, M.
Dynamic modelling of phosphorolytic cleavage catalyzed by pyrimidine-nucleoside phosphorylase
Processes
7
380
2019
Parageobacillus thermoglucosidasius (A0A178U4P5)
-
Okuyama, K.; Hamamoto, T.; Noguchi, T.; Midorikawa, Y.
Molecular cloning and expression of the pyrimidine nucleoside phosphorylase gene from Bacillus stearothermophilus TH 6-2
Biosci. Biotechnol. Biochem.
60
1655-1659
1996
Geobacillus stearothermophilus (P77836), Geobacillus stearothermophilus
html completed