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EC 2.8.1.11 Details

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EC number

2.8.1.11

Accepted name

molybdopterin synthase sulfurtransferase

Reaction

[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine + reduced acceptor = AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH₂-C(O)SH + [cysteine desulfurase]-L-cysteine + oxidized acceptor

Other name(s)

adenylyltransferase and sulfurtransferase MOCS3, Cnx5 (gene name), molybdopterin synthase sulfurylase

Systematic name

[cysteine desulfurase]-S-sulfanyl-L-cysteine:[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly sulfurtransferase

Comment

The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of EC 2.8.1.12, molybdopterin synthase. In the human, the reaction is catalysed by the rhodanese-like C-terminal domain (cf. EC 2.8.1.1) of the MOCS3 protein, a bifunctional protein that also contains EC 2.7.7.80, molybdopterin-synthase adenylyltransferase, at the N-terminal domain.

History

created 2011, modified 2016

EC Tree

1 Oxidoreductases

2 Transferases

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.8.1 Sulfurtransferases

2.8.1.1 thiosulfate sulfurtransferase

2.8.1.2 3-mercaptopyruvate sulfurtransferase

2.8.1.3 thiosulfate—thiol sulfurtransferase

2.8.1.4 tRNA uracil 4-sulfurtransferase

2.8.1.5 thiosulfate—dithiol sulfurtransferase

2.8.1.6 biotin synthase

2.8.1.7 cysteine desulfurase

2.8.1.8 lipoyl synthase

2.8.1.9 molybdenum cofactor sulfurtransferase

2.8.1.10 thiazole synthase

2.8.1.11 molybdopterin synthase sulfurtransferase

2.8.1.12 molybdopterin synthase

2.8.1.13 tRNA-uridine 2-sulfurtransferase

2.8.1.14 tRNA-5-taurinomethyluridine 2-sulfurtransferase

2.8.1.15 tRNA-5-methyluridine⁵⁴ 2-sulfurtransferase

2.8.1.16 L-aspartate semialdehyde sulfurtransferase

2.8.2 Sulfotransferases

2.8.3 CoA-transferases

2.8.3.1 propionate CoA-transferase

2.8.3.2 oxalate CoA-transferase

2.8.3.3 malonate CoA-transferase

2.8.3.4 created 1961, deleted 1964

2.8.3.5 3-oxoacid CoA-transferase

2.8.3.6 3-oxoadipate CoA-transferase

2.8.3.7 succinate—citramalate CoA-transferase

2.8.3.8 acetate CoA-transferase

2.8.3.9 butyrate—acetoacetate CoA-transferase

2.8.3.10 citrate CoA-transferase

2.8.3.11 citramalate CoA-transferase

2.8.3.12 glutaconate CoA-transferase

2.8.3.13 succinate—hydroxymethylglutarate CoA-transferase

2.8.3.14 5-hydroxypentanoate CoA-transferase

2.8.3.15 succinyl-CoA:(R)-benzylsuccinate CoA-transferase

2.8.3.16 formyl-CoA transferase

2.8.3.17 3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase

2.8.3.18 succinyl-CoA:acetate CoA-transferase

2.8.3.19 CoA:oxalate CoA-transferase

2.8.3.20 succinyl-CoA—D-citramalate CoA-transferase

2.8.3.21 L-carnitine CoA-transferase

2.8.3.22 succinyl-CoA—L-malate CoA-transferase

2.8.3.23 caffeate CoA-transferase

2.8.3.24 (R)-2-hydroxy-4-methylpentanoate CoA-transferase

2.8.3.25 bile acid CoA-transferase

2.8.3.26 succinyl-CoA:mesaconate CoA transferase

2.8.3.27 propanoyl-CoA:succinate CoA transferase

2.8.3.28 phenylsuccinyl-CoA transferase

2.8.4 Transferring alkylthio groups

2.8.5 Thiosulfotransferases

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups