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EC 2.7.7.60 Details

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EC number

2.7.7.60

Accepted name

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Reaction

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol

Other name(s)

MEP cytidylyltransferase

Systematic name

CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

CAS registry number

251990-59-7

Comment

The enzyme from Escherichia coli requires Mg²⁺ or Mn²⁺. ATP or UTP can replace CTP, but both are less effective. GTP and TTP are not substrates. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).

History

created 2001

EC Tree

1 Oxidoreductases

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.2 Phosphotransferases with a carboxy group as acceptor

2.7.3 Phosphotransferases with a nitrogenous group as acceptor

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.5 Phosphotransferases with regeneration of donors, apparently catalysing intramolecular transfers (deleted sub-subclass)

2.7.6 Diphosphotransferases

2.7.7 Nucleotidyltransferases

2.7.7.1 nicotinamide-nucleotide adenylyltransferase

2.7.7.2 FAD synthase

2.7.7.3 pantetheine-phosphate adenylyltransferase

2.7.7.4 sulfate adenylyltransferase

2.7.7.5 sulfate adenylyltransferase (ADP)

2.7.7.6 DNA-directed RNA polymerase

2.7.7.7 DNA-directed DNA polymerase

2.7.7.8 polyribonucleotide nucleotidyltransferase

2.7.7.9 UTP—glucose-1-phosphate uridylyltransferase

2.7.7.10 UTP—hexose-1-phosphate uridylyltransferase

2.7.7.11 UTP—xylose-1-phosphate uridylyltransferase

2.7.7.12 UDP-glucose—hexose-1-phosphate uridylyltransferase

2.7.7.13 mannose-1-phosphate guanylyltransferase

2.7.7.14 ethanolamine-phosphate cytidylyltransferase

2.7.7.15 choline-phosphate cytidylyltransferase

2.7.7.16 created 1961, deleted 1972, [transferred to EC 3.1.4.22, deleted 1980]

2.7.7.17 created 1965, deleted 1972, [transferred to EC 3.1.4.23, deleted 1980]

2.7.7.18 nicotinate-nucleotide adenylyltransferase

2.7.7.19 polynucleotide adenylyltransferase

2.7.7.20 created 1965, deleted 1972

2.7.7.21 tRNA cytidylyltransferase

2.7.7.22 mannose-1-phosphate guanylyltransferase (GDP)

2.7.7.23 UDP-N-acetylglucosamine diphosphorylase

2.7.7.24 glucose-1-phosphate thymidylyltransferase

2.7.7.25 tRNA adenylyltransferase

2.7.7.26 created 1961 as EC 3.1.4.8, transferred 1965 to EC 2.7.7.26, deleted 1972

2.7.7.27 glucose-1-phosphate adenylyltransferase

2.7.7.28 nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase

2.7.7.29 created 1972, deleted 2004

2.7.7.30 fucose-1-phosphate guanylyltransferase

2.7.7.31 DNA nucleotidylexotransferase

2.7.7.32 galactose-1-phosphate thymidylyltransferase

2.7.7.33 glucose-1-phosphate cytidylyltransferase

2.7.7.34 glucose-1-phosphate guanylyltransferase

2.7.7.35 ADP ribose phosphorylase

2.7.7.36 aldose-1-phosphate adenylyltransferase

2.7.7.37 aldose-1-phosphate nucleotidyltransferase

2.7.7.38 3-deoxy-manno-octulosonate cytidylyltransferase

2.7.7.39 glycerol-3-phosphate cytidylyltransferase

2.7.7.40 D-ribitol-5-phosphate cytidylyltransferase

2.7.7.41 phosphatidate cytidylyltransferase

2.7.7.42 [glutamine synthetase] adenylyltransferase

2.7.7.43 N-acylneuraminate cytidylyltransferase

2.7.7.44 glucuronate-1-phosphate uridylyltransferase

2.7.7.45 guanosine-triphosphate guanylyltransferase

2.7.7.46 gentamicin 2′′-nucleotidyltransferase

2.7.7.47 streptomycin 3′′-adenylyltransferase

2.7.7.48 RNA-directed RNA polymerase

2.7.7.49 RNA-directed DNA polymerase

2.7.7.50 mRNA guanylyltransferase

2.7.7.51 adenylylsulfate—ammonia adenylyltransferase

2.7.7.52 RNA uridylyltransferase

2.7.7.53 ATP adenylyltransferase

2.7.7.54 phenylalanine adenylyltransferase

2.7.7.55 anthranilate adenylyltransferase

2.7.7.56 tRNA nucleotidyltransferase

2.7.7.57 N-methylphosphoethanolamine cytidylyltransferase

2.7.7.58 (2,3-dihydroxybenzoyl)adenylate synthase

2.7.7.59 [protein-PII] uridylyltransferase

2.7.7.60 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

2.7.7.61 citrate lyase holo-[acyl-carrier protein] synthase

2.7.7.62 adenosylcobinamide-phosphate guanylyltransferase

2.7.7.63 lipoate—protein ligase

2.7.7.64 UTP-monosaccharide-1-phosphate uridylyltransferase

2.7.7.65 diguanylate cyclase

2.7.7.66 malonate decarboxylase holo-[acyl-carrier protein] synthase

2.7.7.67 CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase

2.7.7.68 2-phospho-L-lactate guanylyltransferase

2.7.7.69 GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase

2.7.7.70 D-glycero-β-D-manno-heptose 1-phosphate adenylyltransferase

2.7.7.71 D-glycero-α-D-manno-heptose 1-phosphate guanylyltransferase

2.7.7.72 CCA tRNA nucleotidyltransferase

2.7.7.73 sulfur carrier protein ThiS adenylyltransferase

2.7.7.74 1L-myo-inositol 1-phosphate cytidylyltransferase

2.7.7.75 molybdopterin adenylyltransferase

2.7.7.76 molybdenum cofactor cytidylyltransferase

2.7.7.77 molybdenum cofactor guanylyltransferase

2.7.7.78 GDP-D-glucose phosphorylase

2.7.7.79 tRNA^His guanylyltransferase

2.7.7.80 molybdopterin-synthase adenylyltransferase

2.7.7.81 pseudaminic acid cytidylyltransferase

2.7.7.82 CMP-N,N′-diacetyllegionaminic acid synthase

2.7.7.83 UDP-N-acetylgalactosamine diphosphorylase

2.7.7.84 2′-5′ oligoadenylate synthase

2.7.7.85 diadenylate cyclase

2.7.7.86 cyclic GMP-AMP synthase

2.7.7.87 L-threonylcarbamoyladenylate synthase

2.7.7.88 GDP polyribonucleotidyltransferase

2.7.7.89 [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase

2.7.7.90 8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase

2.7.7.91 valienol-1-phosphate guanylyltransferase

2.7.7.92 3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase

2.7.7.93 phosphonoformate cytidylyltransferase

2.7.7.94 4-hydroxyphenylalkanoate adenylyltransferase

2.7.7.95 mycocerosic acid adenylyltransferase

2.7.7.96 ADP-D-ribose pyrophosphorylase

2.7.7.97 3-hydroxy-4-methylanthranilate adenylyltransferase

2.7.7.98 4-hydroxybenzoate adenylyltransferase

2.7.7.99 N-acetyl-α-D-muramate 1-phosphate uridylyltransferase

2.7.7.100 SAMP-activating enzyme

2.7.7.101 DNA primase DnaG

2.7.7.102 DNA primase AEP

2.7.7.103 L-glutamine-phosphate cytidylyltransferase

2.7.7.104 2-hydroxyethylphosphonate cytidylyltransferase

2.7.7.105 phosphoenolpyruvate guanylyltransferase

2.7.7.106 3-phospho-D-glycerate guanylyltransferase

2.7.7.107 (2-aminoethyl)phosphonate cytidylyltransferase

2.7.7.108 protein adenylyltransferase

2.7.8 Transferases for other substituted phosphate groups

2.7.9 Phosphotransferases with paired acceptors

2.7.10 Protein-tyrosine kinases

2.7.11 Protein-serine/threonine kinases

2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)

2.7.13 Protein-histidine kinases

2.7.13.1 protein-histidine pros-kinase

2.7.13.2 protein-histidine tele-kinase

2.7.13.3 histidine kinase

2.7.14 Protein-arginine kinases

2.7.99 Other protein kinases

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

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Release 2023.1 (January 2023)