EC Explorer

4.3.2.6

γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase

γ-L-glutamyl-butirosin B = butirosin B + 5-oxo-L-proline

btrG (gene name), γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase (5-oxoproline producing)

γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase (5-oxo-L-proline producing)

The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the α-amine of the terminal γ-L-glutamate of the side chain, releasing it as the cyclic 5-oxo-L-proline.

created 2012