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EC 4.3.2.5 Details
show Brenda entryEC number
4.3.2.5
Accepted name
peptidylamidoglycolate lyase
Reaction
[peptide]-(2S)-2-hydroxyglycine = [peptide]-amide + glyoxylate
Other name(s)
α-hydroxyglycine amidating dealkylase,
peptidyl-α-hydroxyglycine α-amidating lyase,
HGAD,
PGL,
PAL,
peptidylamidoglycolate peptidylamide-lyase
Systematic name
[peptide]-(2S)-2-hydroxyglycine peptidyl-amide-lyase (glyoxylate-forming)
CAS registry number
131689-50-4
Comment
Requires zinc. The enzyme acts on the product of the reaction catalysed by EC 1.14.17.3 peptidylglycine monooxygenase, thus removing a terminal glycine residue and leaving a des-glycine peptide amide. In mammals, the two activities are part of a bifunctional protein.
History
created 1992, modified 2019
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1 Oxidoreductases
4 Lyases
4.3.2.1 argininosuccinate lyase
