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BRENDA support

Information on EC 1.2.1.107 - glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)

for references in articles please use BRENDA:EC1.2.1.107

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IUBMB Comments

The enzyme, discovered in bacteria, is very similar to EC 1.2.1.12, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). However, the gene encoding it is located in arsenic resistance islands in the chromosome, next to a gene (arsJ) that encodes a transporter that removes the product, 1-arseno-3-phosphoglycerate, from the cell. Together the two proteins form an arsenic detoxification system.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
fa-gpdh, acylglyceraldehyde-3-phosphate dehydrogenase, [beta-(2-furyl)acryloyl]glyceraldehyde-3-phosphate dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glyceraldehyde 3-phosphate + arsenate + NAD+ = 1-arsono-3-phospho-D-glycerate + NADH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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Highest Expressing Human Cell Lines
Cell Line Links Gene Links