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1.4.1.1: alanine dehydrogenase

This is an abbreviated version!
For detailed information about alanine dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.1

Reaction

L-alanine
+
H2O
 +
NAD+
=
pyruvate
 +
NH3
 +
NADH
 +
H+

Synonyms

(S)alanine dehydrogenase, (S)alanine:NAD oxidoreductase, 40 kDa antigen, ADH, AF1665, ALADH, alanine dehydrogenase, alanine oxidative deaminase, alanine oxidoreductase, ALD, AldA, alpha-alanine dehydrogenase, ApalaDH, AsAlaDH, CQA66_00465, dehydrogenase, alanine, glyoxylate reductive aminase, GxrA, HAADH1, HAADH2, L-Ala dehydrogenase, L-AlaDH, L-AlaDH-Bs, L-alanine dehydrogenase, MtbALD, NAD(H)-dependent L-alanine dehydrogenase, NAD+ dependent amino acid dehydrogenase, NAD+-dependent alanine dehydrogenase, NAD-dependent alanine dehydrogenase, NAD-linked alanine dehydrogenase, NADH-dependent alanine dehydrogenase, OF4Ald, PlaAlaDH, PvRA, pyruvate reductive aminase, Rv2780, ScALD, SCO1773, SheAlaDH, TB43

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.1 alanine dehydrogenase

Temperature Stability

Temperature Stability on EC 1.4.1.1 - alanine dehydrogenase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20
-
10 min, stable
22
-
139 h, no loss of activity
25
-
in presence of 1.5 M KCl stable for 3 months
41
-
30 min, 50% loss of activity
42
-
90 min, stable
45
-
20 min, pH 7.0, stable
50 - 55
AlaDH retains about 10% of maximal activity at 55°C and about 90% at 50°C
52
half-life: 9 min
56
-
half-life: 2.25 min
64
-
30 min, 50% loss of activity
65.7
-
5 min, 50% loss of activity, recombinant enzyme
67
-
10 min, 50% loss of activity, immobilized enzyme
80
-
20 min, stable
81
-
30 min, 50% loss of activity
86
-
melting temperature
90
-
half-life: 55 h in presence of 1.5 M Kcl
additional information