2.1.1.228: tRNA (guanine37-N1)-methyltransferase

This is an abbreviated version!
For detailed information about tRNA (guanine37-N1)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.228

2.1.1.228

methyltransferases

anticodon

adomet

1-methylguanosine

drug development

n2-guanine

trmt10a

1-methyladenine

adomet-dependent

5-methyluridine

trmfo

n1-methylation

methyl-deficient

7-methylguanine

spout

epitranscriptome

nsun2-mediated

medicine

Reaction

Synonyms

At3g56120, aTrm5a methyltransferase, aTrm5a/Taw22-like enzyme, AtTrm5a, bacterial tRNA (guanine37-N1)-methyltransferase, bacterial tRNA-(N1G37) methyltransferase, EC 2.1.1.31, EcTrmD, HiTrmD, HsTrm5, m1G37 tRNA methyltransferase, m1G37-forming tRNA methyltransferase, Mj-Trm5, MJ0883, MjTrm5, MjTrm5b, mono-functional methyltransferase, More, MtbTrmD, NEQ228, PA14_15990, PAB2272, PAB_RS03940, PaTrm5a, PaTrm5b, PaTrmD, SaTrmD, Ta0997, TAW22, transfer RNA (m1G37) methyltransferase, Trm1, TRM5, Trm5a, Trm5a/Taw22-like enzyme, trm5b, Trm5p, TrmD, TRMT5, tRNA (guanine(37)-N1)-methyltransferase 1, tRNA (guanine37-N1)-methyltransferase, tRNA (guanosine-1) methyltransferase, tRNA (m1G37) methyltransferase, tRNA (m1G37)-methyltransferase, tRNA m1G37 methyltransferase, tRNA methyltransferase, tRNA methyltransferase 5, tRNA methyltransferase D, tRNA(m(1)G37)methyltransferase, tRNA(m1G37) methyltransferase, tRNA(m1G37) MTase, tRNA(m1G37)methyltransferase, tRNA-(N1G37) methyltransferase, tRNAPhe:imG2 methyltransferase

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.228 tRNA (guanine37-N1)-methyltransferase

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Results	in table
1	Activating Compound
43500	AA Sequence
16	Application
31	Cloned(Commentary)
49	Cofactor
17	Crystallization (Commentary)
98	Disease/ Diagnostics
3	Expression
219	General Information
3	General Stability
89	IC50 Value
190	Inhibitors
40	kcat/KM [mM/s]
27	Ki Value [mM]
91	KM Value [mM]
8	Localization
44	Metals/Ions
8	Molecular Weight [Da]
116	Natural Substrates/ Products (Substrates)
168	Organism
3	Pathway
201	PDB ID
29	pH Optimum
5	pH Range
126	Protein Variants
23	Purification (Commentary)
9	Reaction
103	Reference
3	Source Tissue
269	Substrates and Products (Substrate)
58	Subunits
226	Synonyms
1	Systematic Name
28	Temperature Optimum [°C]
3	Temperature Stability [°C]
43	Turnover Number [1/s]

pH Range

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pH Range on EC 2.1.1.228 - tRNA (guanine37-N1)-methyltransferase

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6 - 8.5

Streptococcus pneumoniae

pH 6.0: about 50% of maximal activity, pH 8.5: about 75% of maximal activity

662010

6 - 9.8

Methanocaldococcus jannaschii

Q58293

preincubation of Trm5 at pH 6.0, followed by adjustment of the solution to pH 8.0, does not cause irreversible inactivation of the enzyme. Enzyme treated in this manner retained equivalent activity in single-turnover assay

6.4 - 8.4

6.5 - 9.5

pH-activity profile