2.1.1.246: [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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For detailed information about [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.246

2.1.1.246

methyltransferases

euchromatic

methanosarcina

barkeri

rna-directed

methanogenesis

monomethylamine

24-nucleotide

dimethylamine

biofuel production

synthesis

Reaction

a [methyl-Co(III) methanol-specific corrinoid protein]

a [Co(I) methanol-specific corrinoid protein]

Synonyms

Co-methyl-5-hydroxybenzimidazolylcobamide:2-mercapto-ethanesulphonic acid methyltransferase, methanol-specific methyltransferase 2, methanol:cob(I)alamin methyltransferase, methanol:coenzyme M methyltransferase, methylcobalamin:coenzyme M methyltransferase, methylcobamide:coenzyme M methyltransferase, methylcobamide:CoM methyltransferase, methyltransferase 2, MT2, MT2-A, MT2-M, mtaA

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.246 [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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Results	in table
4	Activating Compound
47	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
4	Expression
13	General Information
3	Inhibitors
3	KM Value [mM]
9	Metals/Ions
3	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
30	Organism
3	Pathway
8	pH Optimum
6	Protein Variants
6	Purification (Commentary)
2	Reaction
14	Reference
7	Source Tissue
14	Specific Activity [micromol/min/mg]
17	Substrates and Products (Substrate)
4	Subunits
32	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]

Metals Ions

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Metals Ions on EC 2.1.1.246 - [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase

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Co2+

2 entries

Zn2+

6 entries

additional information

Methanosarcina barkeri

Zn21 or Co21 are required for MtaA activity, Zn2+ can be replaced by Co2+ but not by Mg2+, the kinetics of activation by Co2+ being similarily slow. About 1 mol of transition metal is bound per mol of protein. The role of the transition metal in MtaA is to lower the microscopic pKa of the thiol group of coenzyme M by coordination to the zinc, and thus to increase its nucleophilicity for methyl group attack, pKZn2+ of MtaA is over 15

717562