2.1.1.292: carminomycin 4-O-methyltransferase

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For detailed information about carminomycin 4-O-methyltransferase, go to the full flat file.

Reaction

Synonyms

4-O-methyltransferase, anthracycline 4-O-methyltransferase, anthracycline methyltransferase, carminomycin 4-OMT, class I methyltransferase, COMT, DauK, DnrK

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.292 carminomycin 4-O-methyltransferase

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Results	in table
5	AA Sequence
1	Application
7	Cloned(Commentary)
4	Cofactor
2	Crystallization (Commentary)
10	General Information
3	Inhibitors
3	kcat/KM [mM/s]
6	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
11	Organism
5	Pathway
57	PDB ID
3	pH Optimum
1	pH Range
6	Protein Variants
3	Purification (Commentary)
1	Reaction
11	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
24	Substrates and Products (Substrate)
3	Subunits
18	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Turnover Number [1/s]

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Application on EC 2.1.1.292 - carminomycin 4-O-methyltransferase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

synthesis

Streptomyces peucetius

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production of a new hybrid anthracycline antibiotic. Expression in Streptomyces violaceus pMK100 (epelmycin producer). The transformant produces the hybrid anthracycline antibiotic 7-O-L-hodosaminyl-4-O-methyl-epsilon-rhodomycinone (4-O-methylepelmycin D) together with host epelmycins when cultured in antibiotic production medium in the presence of thiostrepton. Attempts on production of hybrid 4-O-methylaclarubicin and 4-O-methyl-l-deoxyobelmycin by the transformants of aclarubicin and 1-deoxyobelmycin producers are unsuccessful

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