2.1.1.292: carminomycin 4-O-methyltransferase
This is an abbreviated version!
For detailed information about carminomycin 4-O-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.292
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2.1.1.292
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methyltransferases
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sam-dependent
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s-adenosyl-l-homocysteine
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daunorubicin
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peucetius
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s-adenosyl-l-methionine-dependent
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synthesis
- 2.1.1.292
- methyltransferases
-
sam-dependent
- s-adenosyl-l-homocysteine
- daunorubicin
- peucetius
-
s-adenosyl-l-methionine-dependent
- synthesis
Reaction
Synonyms
4-O-methyltransferase, anthracycline 4-O-methyltransferase, anthracycline methyltransferase, carminomycin 4-OMT, class I methyltransferase, COMT, DauK, DnrK
ECTree
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Cofactor
Cofactor on EC 2.1.1.292 - carminomycin 4-O-methyltransferase
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additional information
design, synthesis, and evaluation of stable, functional AdoMet isosteres that are resistant to the primary contributors to AdoMet degradation (depurination, intramolecular cyclization, and sulfonium epimerization). The AdoMet surrogates to serve as competent enzyme cosubstrates and to bind a prototypical class I model methyltransferase (DnrK) in a manner nearly identical to AdoMet. Half-lives of AdoMet derivatives, overview. Analysis of DnrK ligand-bound structures: DnrK-S-adenosyl-(3S)-3-amino-3-(1H-tetrazol-5-yl)propane-1-thiol and DnrK-S-adenosyl-(3S)-3-amino-3-(1H-tetrazol-5-yl)propane-1-thiol-carminomycin
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S-adenosyl-L-methionine
S-adenosyl-L-methionine (AdoMet) is an essential enzyme cosubstrate