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2 acetyl-CoA
CoA + acetoacetyl-CoA
reaction of EC 2.3.1.9
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2,4-dichlorophenoxybutyric acid + acetyl-CoA
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3-oxo-5,6-dehydrosuberyl-CoA + CoA
2,3-dehydroadipyl-CoA + acetyl-CoA
3-oxodecanoyl-CoA + CoA
acetyl-CoA + octanoyl-CoA
degradation of 3-oxodecanoyl-CoA into acetyl-CoA and octanoyl-CoA by human mitochondrial 3-ketoacyl-CoA thiolase, substrate binding mode and reaction mechanism, overview
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5-methyl-3-oxo-4-hexenoyl-CoA + CoA
3-methylcrotonyl-CoA + acetyl-CoA
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7-methyl-3-oxo-6-octenoyl-CoA + CoA
5-methylhex-4-enoyl-CoA + acetyl-CoA
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acetoacetyl-CoA + CoA
2 acetyl-CoA
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acetyl-CoA + H2O
acetate + CoA
acyl-CoA + acetyl-CoA
CoA + 3-oxoacyl-CoA
butyryl-CoA + H2O
butanoate + CoA
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acetyl-CoA hydrolase activity
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
CoA + 3-oxodecanoyl-CoA
acetyl-CoA + octanoyl-CoA
CoA + 3-oxododecanoyl-CoA
acetyl-CoA + decanoyl-CoA
CoA + 3-oxoheptanoyl-CoA
acetyl-CoA + pentanoyl-CoA
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CoA + 3-oxohexadecanoyl-CoA
acetyl-CoA + tetradecanoyl-CoA
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CoA + 3-oxohexanoyl-CoA
acetyl-CoA + butanoyl-CoA
CoA + 3-oxolauryl-CoA
acetyl-CoA + decanoyl-CoA
CoA + 3-oxooctanoyl-CoA
acetyl-CoA + hexanoyl-CoA
CoA + 3-oxopalmitoyl-CoA
acetyl-CoA + tetradecanoyl-CoA
CoA + 3-oxopentanoyl-CoA
acetyl-CoA + propanoyl-CoA
CoA + acetoacetyl-CoA
2 acetyl-CoA
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r
CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
coenzyme A + acetoacetyl-CoA
2 acetyl-CoA
dodecanoyl-CoA + H2O
dodecanoate + CoA
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acetyl-CoA hydrolase activity
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hexanoyl-CoA + H2O
hexanoate + CoA
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acetyl-CoA hydrolase activity
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palmitoyl-CoA + H2O
palmitate + CoA
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acetyl-CoA hydrolase activity
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propionyl-CoA + H2O
propionate + CoA
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acetyl-CoA hydrolase activity
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additional information
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3-oxo-5,6-dehydrosuberyl-CoA + CoA
2,3-dehydroadipyl-CoA + acetyl-CoA
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3-oxo-5,6-dehydrosuberyl-CoA + CoA
2,3-dehydroadipyl-CoA + acetyl-CoA
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acetyl-CoA + H2O
acetate + CoA
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3-ketoacyl-CoA thiolase activity
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acetyl-CoA + H2O
acetate + CoA
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best acyl-CoA substrate, acetyl-CoA hydrolase activity
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acetyl-CoA + H2O
acetate + CoA
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preferred substrate, 3-ketoacyl-CoA thiolase activity
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acetyl-CoA + H2O
acetate + CoA
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acetyl-CoA + H2O
acetate + CoA
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acyl-CoA + acetyl-CoA
CoA + 3-oxoacyl-CoA
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acyl-CoA + acetyl-CoA
CoA + 3-oxoacyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
metabolism in the peroxisome influences metabolism in the lipid body
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
enzyme catalyses step of fatty acid beta-oxidation
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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two-step reaction
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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enzyme catalyses the last step in the beta-oxidation cycle
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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enzyme catalyses step of fatty acid beta-oxidation
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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enzyme catalyses the last step in the beta-oxidation cycle
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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enzyme plays important role in peroxisomal beta-oxidation, in addition the enzyme may facilitate the intraperoxysomal movement of sterols and certain other lipids
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
two-step reaction
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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enzyme catalyses the last step in the beta-oxidation cycle
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
enzyme catalyses the last step in the beta-oxidation cycle
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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enzyme catalyses step of fatty acid beta-oxidation
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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two-step reaction
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CoA + 3-oxoacyl-CoA
acyl-CoA + acetyl-CoA
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enzyme catalyses the last step in the beta-oxidation cycle
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CoA + 3-oxodecanoyl-CoA
acetyl-CoA + octanoyl-CoA
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CoA + 3-oxodecanoyl-CoA
acetyl-CoA + octanoyl-CoA
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CoA + 3-oxodecanoyl-CoA
acetyl-CoA + octanoyl-CoA
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CoA + 3-oxodecanoyl-CoA
acetyl-CoA + octanoyl-CoA
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CoA + 3-oxodecanoyl-CoA
acetyl-CoA + octanoyl-CoA
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CoA + 3-oxodecanoyl-CoA
acetyl-CoA + octanoyl-CoA
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CoA + 3-oxododecanoyl-CoA
acetyl-CoA + decanoyl-CoA
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CoA + 3-oxododecanoyl-CoA
acetyl-CoA + decanoyl-CoA
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CoA + 3-oxododecanoyl-CoA
acetyl-CoA + decanoyl-CoA
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CoA + 3-oxododecanoyl-CoA
acetyl-CoA + decanoyl-CoA
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CoA + 3-oxohexanoyl-CoA
acetyl-CoA + butanoyl-CoA
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CoA + 3-oxohexanoyl-CoA
acetyl-CoA + butanoyl-CoA
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highest activity with 3-oxohexanoyl-CoA
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CoA + 3-oxohexanoyl-CoA
acetyl-CoA + butanoyl-CoA
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CoA + 3-oxohexanoyl-CoA
acetyl-CoA + butanoyl-CoA
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CoA + 3-oxohexanoyl-CoA
acetyl-CoA + butanoyl-CoA
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highest activity with 3-oxohexanoyl-CoA
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CoA + 3-oxohexanoyl-CoA
acetyl-CoA + butanoyl-CoA
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CoA + 3-oxohexanoyl-CoA
acetyl-CoA + butanoyl-CoA
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highest activity with 3-oxohexanoyl-CoA
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CoA + 3-oxohexanoyl-CoA
acetyl-CoA + butanoyl-CoA
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CoA + 3-oxohexanoyl-CoA
acetyl-CoA + butanoyl-CoA
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CoA + 3-oxohexanoyl-CoA
acetyl-CoA + butanoyl-CoA
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highest activity with 3-oxohexanoyl-CoA
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CoA + 3-oxolauryl-CoA
acetyl-CoA + decanoyl-CoA
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CoA + 3-oxolauryl-CoA
acetyl-CoA + decanoyl-CoA
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CoA + 3-oxolauryl-CoA
acetyl-CoA + decanoyl-CoA
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CoA + 3-oxooctanoyl-CoA
acetyl-CoA + hexanoyl-CoA
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CoA + 3-oxooctanoyl-CoA
acetyl-CoA + hexanoyl-CoA
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CoA + 3-oxooctanoyl-CoA
acetyl-CoA + hexanoyl-CoA
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CoA + 3-oxooctanoyl-CoA
acetyl-CoA + hexanoyl-CoA
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CoA + 3-oxooctanoyl-CoA
acetyl-CoA + hexanoyl-CoA
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CoA + 3-oxooctanoyl-CoA
acetyl-CoA + hexanoyl-CoA
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CoA + 3-oxooctanoyl-CoA
acetyl-CoA + hexanoyl-CoA
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CoA + 3-oxopalmitoyl-CoA
acetyl-CoA + tetradecanoyl-CoA
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CoA + 3-oxopalmitoyl-CoA
acetyl-CoA + tetradecanoyl-CoA
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CoA + 3-oxopalmitoyl-CoA
acetyl-CoA + tetradecanoyl-CoA
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CoA + 3-oxopentanoyl-CoA
acetyl-CoA + propanoyl-CoA
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CoA + 3-oxopentanoyl-CoA
acetyl-CoA + propanoyl-CoA
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CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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CoA + acetoacetyl-CoA
acetyl-CoA + acetyl-CoA
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coenzyme A + acetoacetyl-CoA
2 acetyl-CoA
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coenzyme A + acetoacetyl-CoA
2 acetyl-CoA
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additional information
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the peroxisomal isozyme is a biodegradative type 1 thiolase showing potential for redox control of peroxisomal fatty acid beta-oxidation, KAT activity in peroxisomes is influenced by a disulfide/dithiol change linking fatty acid beta-oxidation, overview
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additional information
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the peroxisomal isozyme is a biodegradative type 1 thiolase showing potential for redox control of peroxisomal fatty acid beta-oxidation, KAT activity in peroxisomes is influenced by a disulfide/dithiol change linking fatty acid beta-oxidation, overview
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additional information
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3-oxoacyl-CoA homologues from acetoacetyl to 3-oxopalmitoyl-CoA
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additional information
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low activity with myristoyl-CoA
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additional information
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active with all 3-oxoacyl-CoAs (C4-C10) tested
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additional information
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highest activity with medium- and long-chain 3-oxoacyl-CoA substrates, but also shows significant activity with acetoacetyl-CoA (20-30% of the optimum with 3-oxohexanoyl-CoA)
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additional information
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3-oxoacyl-coenzyme A derivatives containing 4 to 16 carbons
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additional information
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highest activities with medium-chain substrates
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additional information
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highest activities with medium-chain substrates
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additional information
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low activity with butyryl-CoA
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additional information
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activity of the enzyme towards 3-oxoacy-CoAs increased with increasing chain length of the substrate
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additional information
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the enzyme catalyzes the thiolytic cleavage of medium-chain to long-chain 3-oxoacyl-CoAs to acetyl-CoA and a fatty acyl-CoA shortened by two C atom, the reaction involves residues C382, C92, and H352, overview. The enzyme can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA, EC 2.3.1.9
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additional information
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the enzyme catalyzes the thiolytic cleavage of medium-chain to long-chain 3-oxoacyl-CoAs to acetyl-CoA and a fatty acyl-CoA shortened by two C atom, the reaction involves residues C382, C92, and H352, overview. The enzyme can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA, EC 2.3.1.9
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additional information
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active site structure and CoA binding structure, and enzyme substrate specificity, detailed overview
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additional information
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active site structure and CoA binding structure, and enzyme substrate specificity, detailed overview
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additional information
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3-oxoacyl-CoA homologues from acetoacetyl to 3-oxopalmitoyl-CoA
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additional information
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additional information
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3-oxoacyl-CoA homologues from acetoacetyl to 3-oxopalmitoyl-CoA
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additional information
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thiolase A and B possess virtually the same substrate specificity
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additional information
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key enzyme involved in fatty acid oxidation
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additional information
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the enzyme is involved in fatty acid beta-oxidation
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additional information
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analysis of the substrate chain length specificity of the enzyme, high preference for acetyl-CoA
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additional information
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highest activity with medium- and long-chain 3-oxoacyl-CoA substrates, but also shows significant activity with acetoacetyl-CoA (20-30% of the optimum with 3-oxohexanoyl-CoA)
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additional information
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the active site of thiolase can also catalyse the synthesis of acetyl-Co from two molecules of acetyl-CoA
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additional information
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sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in trafficing of sterols and oxidation of branched-chain fatty acids
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additional information
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sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in trafficing of sterols and oxidation of branched-chain fatty acids
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additional information
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low activity with acetyl-CoA
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additional information
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3-oxoacyl-CoA homologues from acetoacetyl to 3-oxopalmitoyl-CoA
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additional information
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low activity with hexanoyl-CoA
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additional information
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low activity with myristoyl-CoA
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additional information
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low activity with butyryl-CoA
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additional information
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acetoacetyl-CoA is a poor substrate
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additional information
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acts on 3-oxoacyl-CoA compounds of various chain lengths
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additional information
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first enzyme of the most common biosynthetic pathway for polyhydroxyalkanoates, overview
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additional information
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first enzyme of the most common biosynthetic pathway for polyhydroxyalkanoates, overview
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